Relapse of major depression after complete and partial remission during a 2-year follow-up

Pintor, Luís; Gastó, Cristòbal; Navarro, Vı́ctor; Torres, Xavier; Fañanás, Lourdes

doi:10.1016/s0165-0327(01)00480-3

Cited by 86 publications

(59 citation statements)

References 34 publications

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“…Another reason might be the fact that anxiety symptoms were also observed in these patients during the acute period. The studies show that depression that is accompanied by somatic symptoms and anxiety symptoms is more resistant to treatment and somatic symptoms recover later [13]. Ongoing residual somatic symptoms and anxiety symptoms, on the other hand, might mainly be associated with more frequent relapses and more deterioration in functionality.…”

Section: Discussionmentioning

confidence: 99%

“…It was determined that patients who had genital symptoms as residual symptoms had a higher risk of recurrence in follow-up, compared to those who did not [12]. Examining the studies [13][14][15] that investigate the effect of residual symptoms on recurrence, it is asserted that a partial improvement increases the recurrence risk of residual symptoms; however, they do not indicate which residual symptoms are effective individually.…”

mentioning

confidence: 99%

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Comparison Between Clinical Features and Residual Depressive Symptoms of Patients with Bipolar Depressive and Unipolar Depressive Disorder in Remission

Yenilmez¹

2014

j Psychiatry

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Comparison Between Clinical Features and Residual Depressive Symptoms of Patients with Bipolar Depressive and Unipolar Depressive Disorder in Remission

Yenilmez¹

2014

j Psychiatry

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“…Two sources were identified for relapse/remission rates in patients with a partial remission. 177 Pintor et al 174 was chosen for the primary analysis, as it was a cohort study and so may be more likely to reflect routine care. However, it was a Spanish study, and so the study by Scott et al 177 a UK RCT, was used to provide an alternative Outcome rates for drop outs…”

Section: Appendix 2 Glossary Of Terms Associated With Trial-related Imentioning

confidence: 99%

Evaluating the effectiveness and cost-effectiveness of British Sign Language Improving Access to Psychological Therapies: an exploratory study

Young

Rogers

Davies

et al. 2017

Health Serv Deliv Res

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BackgroundImproving Access to Psychological Therapies (IAPT) is a National Institute for Health and Care Excellence-approved approach to intervention for depression and/or anxiety. This exploratory study sets the groundwork for comparing psychological therapies for Deaf sign language users experiencing anxiety and/or depression, delivered in British Sign Language (BSL) by a Deaf therapist with usual access through an interpreter within the IAPT national programme.Objectives(1) To explore the following questions: (a) is BSL-IAPT more effective than standard IAPT for Deaf people with anxiety and/or depression? and (b) is any additional benefit from BSL-IAPT worth any additional cost to provide it? (2) To establish relevant BSL versions of assessment tools and methods to answer research questions (a) and (b). (3) To gauge the feasibility of a larger-scale definitive study and to inform its future design.DesignA mixed-methods exploratory study combing an economic model to synthesise data from multiple sources; a qualitative study of understanding and acceptability of randomisation and trial terminology; statistical determination of clinical cut-off points of standardised assessments in BSL; secondary data analysis of anonymised IAPT client records; realist inquiry incorporating interviews with service providers and survey results.SettingsIAPT service providers (NHS and private); the Deaf community.ParticipantsDeaf people who use BSL and who are clients of IAPT services (n = 502); healthy Deaf volunteers (n = 104); IAPT service providers (NHS and private) (n = 118).InterventionsIAPT at steps 2 and 3.Main outcome measuresReliable recovery and reliable improvement defined by IAPT; Deaf community views on the acceptability of randomisation; BSL terminology for trial-related language; clinical cut-off measurements for the BSL versions of the Patient Health Questionnaire-9 items (PHQ-9) and the Generalised Anxiety Disorder-7 (GAD-7); a valid BSL version of the EuroQol-5 Dimensions five-level version (EQ-5D-5L); costs, quality-adjusted life-years and incremental cost-effectiveness ratios.Data sourcesIAPT service provider anonymised records of the characteristics and clinical outcomes of Deaf BSL users of BSL-IAPT and of standard IAPT; published literature.ResultsRandomisation may be acceptable to Deaf people who use IAPT if linguistic and cultural requirements are addressed. Specifications for effective information in BSL for recruitment have been established. A valid EQ-5D-5L in BSL has been produced. The clinical cut-off point for the GAD-7 BSL is 6 and for the PHQ-9 BSL is 8. No significant difference in rates of reliable recovery and reliable improvement between Deaf users of standard IAPT or BSL-IAPT has been found. Whether or not BSL-IAPT is more cost-effective than standard IAPT is uncertain.LimitationsThe small number of participating standard IAPT services who have seen Deaf clients means that there is statistical uncertainty in the comparable clinical outcome result. Clinical cut-off scores have not been verified through gold standard clinical interview methodology. Limited data availability means that whether or not BSL-IAPT is more cost-effective than standard IAPT is uncertain.ConclusionsThere is a lack of evidence to definitively compare reliable recovery and reliable improvement between Deaf users of standard IAPT and BSL-IAPT. Instrumentation and prerequisites for a larger-scale study have been established.Future workA prospective observational study for definitive results is justified.FundingThe National Institute for Health Research Health Services and Delivery Research programme.

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“…85,93,[133][134][135][136][137] In adult studies, patients who do not reach remission are more likely to have recurrent or chronic depression, suicidal ideation or behavior, and continuing impairment in work, relationships, and overall quality of life. [138][139][140][141][142][143][144][145][146][147][148] Similar evidence on the impact of nonremission is not available for youth.…”

Section: Rationale and Evidencementioning

confidence: 99%

“…• Guideline 34,35,48,49 • Quasi/nonexperimental [138][139][140][141][142][143][144][145][146][147][148] • RCT …”

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Evidence for the Management of Adolescent Depression

et al. 2013

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Adolescent depression is a prevalent and disabling condition resulting in emotional suffering and social and educational dysfunction. Care for adolescent depression is suboptimal and could be improved through the development and use of quality indicators (QIs). This article reports on the development of a care pathway and QIs for the primary and specialty care management of adolescent depression from case identification through symptom remission. It presents evidence from a review of adolescent clinical practice guidelines and research literature to support QIs at critical nodes in the pathway, and describes implications for practice based on existing evidence. Barriers to measure development are identified, including gaps in empirical evidence, and a research agenda is suggested. Pediatrics 2013;132:e996-e1009

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Relapse of major depression after complete and partial remission during a 2-year follow-up

Cited by 86 publications

References 34 publications

Comparison Between Clinical Features and Residual Depressive Symptoms of Patients with Bipolar Depressive and Unipolar Depressive Disorder in Remission

Comparison Between Clinical Features and Residual Depressive Symptoms of Patients with Bipolar Depressive and Unipolar Depressive Disorder in Remission

Evaluating the effectiveness and cost-effectiveness of British Sign Language Improving Access to Psychological Therapies: an exploratory study

Evidence for the Management of Adolescent Depression

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