Rejection prediction of isopropylantipyrine and antipyrine by nanofiltration membranes based on the Spiegler–Kedem–Katchalsky model

Wu, Fang; Feng, Li; Zhang, Liqiu

doi:10.1016/j.desal.2015.01.046

Cited by 17 publications

(17 citation statements)

References 34 publications

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“…The purities of all drugs were more than 98%. The stock solution was prepared by dissolving each drug 20 mg/L in methanol solvent and stored at -4 o C [24,29]. All chemicals were at least reagent grade.…”

Section: Membrane and Chemicalsmentioning

confidence: 99%

“…Recently, some researchers investigated the removal performance of drugs by NF technology [20][21][22][23][24][25]. Three major drug removal mechanisms are proposed, including steric exclusion, electrostatic repulsion and adsorption.…”

Section: Introductionmentioning

confidence: 99%

“…Besides, hydrophobic interaction is also noticeable between some neutral drugs and NF in the experiments. However, hydrophobic interaction may cause the different consequences, which need more researchers' efforts to investigate [24][25][26]. On the one hand, hydrophobic interaction causes the membrane fouling and makes the membrane pore size become smaller, which can increase the removal efficiency.…”

Section: Introductionmentioning

confidence: 99%

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Rejection rate and mechanisms of drugs in drinking water by nanofiltration technology

Feng

Zhang

et al. 2017

Environmental Engineering Research

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Nanofiltration (NF) technology is a membrane-based separation process, which has been pervasively used as the high-effective technology for drinking water treatment. In this study, a kind of composite polyamide NF thin film is selected to investigate the removal efficiencies and mechanisms of 14 trace drugs, which are commonly and frequently detected in the drinking water. The results show that the removal efficiencies of most drugs are quite high, indicating the NF is an effective technology to improve the quality of drinking water. The removal efficiencies of carbamazepine, acetaminophen, estradiol, antipyrine and isopropyl-antipyrine in ultrapure water are 78.8 ± 0.8%, 16.4 ± 0.5%, 65.4 ± 1.8%, 71.1 ± 1.5% and 89.8 ± 0.38%, respectively. Their rejection rates increase with the increasing of their three-dimensional sizes, which indicates that the steric exclusion plays a significant role in removal of these five drugs. The adsorption of estradiol with the strongest hydrophobicity has been studied, which indicates that adsorption is not negligible in terms of removing this kind of hydrophobic neutral drugs by NF technology. The removal efficiencies of indomethacin, diclofenac, naproxen, ketoprofen, ibuprofen, clofibric acid, sulfamethoxazole, amoxicillin and bezafibrate in ultrapure water are 81 ± 0.3%, 86.3 ± 0.5%, 85.7 ± 0.4%, 93.3 ± 0.3%, 86.6 ± 2.5%, 90.6 ± 0.4%, 59.7 ± 1.7%, 80.3 ± 1.4% and 80 ± 0.5%, respectively. For these nine drugs, their rejection rates are better than the above five drugs because they are negatively charged in ultrapure water. Meanwhile, the membrane surface presents the negative charge. Therefore, both electrostatic repulsion and steric exclusion are indispensable in removing these negatively charged drugs. This study provides helpful and scientific support of a highly effective water treatment method for removing drugs pollutants from drinking water.

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Section: Membrane and Chemicalsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Rejection rate and mechanisms of drugs in drinking water by nanofiltration technology

Feng

Zhang

et al. 2017

Environmental Engineering Research

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“…This model was incorporated into a freely available computer programme, NanoFiltran, developed by Geraldes and Brites Alves [117] and further developed by incorporation of the increase in solute concentration along the membrane module for seawater desalination [118], however it has not been applied to PPCPs in the literature. While the DSPM&DE type models are suited for charged solutes, models based on the Spiegler-Kedem-Katchalsky equations (SKK model) has been successfully applied to neutral molecules, including the pharmaceuticals isopropylantipyrine and antipyrine [119]. A quasi-empirical model combining predictions for neutral and charged solutes (taking pH dependency into account) was applied reasonably successfully for carpamazepine, ibuprofen, sufadiazine, sulfamethoxazone and sulfamethazone [50].…”

Section: Nanofiltration For Pharmaceutical Removal From Watermentioning

confidence: 99%

Incorporation of Graphene-Related Carbon Nanosheets in Membrane Fabrication for Water Treatment: A Review

Lawler

2016

Membranes

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The minimization of the trade-off between the flux and the selectivity of membranes is a key area that researchers are continually working to optimise, particularly in the area of fabrication of novel membranes. Flux versus selectivity issues apply in many industrial applications of membranes, for example the unwanted diffusion of methanol in fuel cells, retention of valuable proteins in downstream processing of biopharmaceuticals, rejection of organic matter and micro-organisms in water treatment, or salt permeation in desalination. The incorporation of nanosheets within membrane structures can potentially lead to enhancements in such properties as the antifouling ability, hydrophilicy and permeability of membranes, with concomitant improvements in the flux/selectivity balance. Graphene nanosheets and derivatives such as graphene oxide and reduced graphene oxide have been investigated for this purpose, for example inclusion of nanosheets within the active layer of Reverse Osmosis or Nanofiltration membranes or the blending of nanosheets as fillers within Ultrafiltration membranes. This review summarizes the incorporation of graphene derivatives into polymeric membranes for water treatment with a focus on a number of industrial applications, including desalination and pharmaceutical removal, where enhancement of productivity and reduction in fouling characteristics have been afforded by appropriate incorporation of graphene derived nanosheets during membrane fabrication.

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“…Membrane separation technology is gaining importance worldwide in recent years for achieving an effective separation of the target component although there are some existing disparities within the process itself [9][10][11]. The nanofiltration (NF) process which exhibits high rejection, high water permeability and moderate pressure requirements is growing as a hopeful technology for efficient reservation of Chinese medicine ingredients from water extraction without heat effect [12][13][14]. NF has two remarkable features: one is the molecular weight cut-offs (MWCO) between reverse osmosis (RO) membranes and ultrafiltration (UF) membranes, which ranges from 200 to 2000 Da; the other is the separation of electrolytes due to the materials containing charged groups [15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Concentrating phenolic acids from Lonicera japonica by nanofiltration technology

Li¹,

Ma²,

Li³

et al. 2017

AIP Conference Proceedings

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ARTICLES YOU MAY BE INTERESTED INCrystallization of bovine insulin on a flow-free droplet-based platform AIP Conference Proceedings 1820, 030003 (2017) Abstract. Response surface analysis methodology was used to optimize the concentrate process of phenolic acids from Lonicera japonica by nanofiltration technique. On the basis of the influences of pressure, temperature and circulating volume, the retention rate of neochlorogenic acid, chlorogenic acid and 4-dicaffeoylquinic acid were selected as index, molecular weight cut-off of nanofiltration membrane, concentration and pH were selected as influencing factors during concentrate process. The experiment mathematical model was arranged according to Box-Behnken central composite experiment design. The optimal concentrate conditions were as following: nanofiltration molecular weight cut-off, 150 Da; solutes concentration, 18.34 μg/mL; pH, 4.26. The predicted value of retention rate was 97.99% under the optimum conditions, and the experimental value was 98.03±0.24%, which was in accordance with the predicted value. These results demonstrate that the combination of Box-Behnken design and response surface analysis can well optimize the concentrate process of Lonicera japonica water-extraction by nanofiltration, and the results provide the basis for nanofiltration concentrate for heat-sensitive traditional Chinese medicine.

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Rejection prediction of isopropylantipyrine and antipyrine by nanofiltration membranes based on the Spiegler–Kedem–Katchalsky model

Cited by 17 publications

References 34 publications

Rejection rate and mechanisms of drugs in drinking water by nanofiltration technology

Rejection rate and mechanisms of drugs in drinking water by nanofiltration technology

Incorporation of Graphene-Related Carbon Nanosheets in Membrane Fabrication for Water Treatment: A Review

Concentrating phenolic acids from Lonicera japonica by nanofiltration technology

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