Reissner's Membrane After Kanamycin Administration

Estradiol protects the cochlea against gentamicin ototoxicity through inhibition of the JNK pathway

“…The loss of these cells starts in the first row of the basal turns and progresses to the outer rows and to the apical turns. At the subcellular level, vesiculations of the mitochondrial cristae, swelling of the nucleus, loss of ribosomes, and changes in the structure of the plasma membrane occur after aminoglycoside treatment (Kaneko et al, 1970;Theopold, 1977;Forge, 1985). Although gentamicin ototoxicity shows similarities among species, as mentioned above, several problems will be encountered in the clinical usage of E2 in humans.…”