Reirradiation Using High-Dose-Rate Interstitial Brachytherapy for Locally Recurrent Cervical Cancer: A Single Institutional Experience

Abstract

Reirradiation using HDR-ISBT is effective and feasible in patients with recurrent cervical cancer. Our 2-clinical variable prognostic model might enable physicians to identify patients who would not derive clinical benefit from HDR-ISBT and offer them the opportunity to receive other types of treatment.

Computed tomography planned interstitial brachytherapy for recurrent gynecologic cancer

“…3). This has previously been shown in other series and is likely the result of tumor size being a marker for aggressiveness of disease (25).…”

“…Many series of ISBT include some patients with recurrent disease who have previously received EBRT or brachytherapy intermixed with patients at the first presentation (12, 13,16e22). In addition to the classic series by Nag et al (23) published in 1998, there has been an increasing number of studies examining reirradiation alone with ISBT for patients with recurrent gynecologic cancer (24,25). For the first time, prospective evidence is available from Spanish investigators examining the role of ISBT in recurrent gynecologic cancer (26).…”

Radiotherapy for isolated recurrent epithelial ovarian cancer: A single institutional experience

“…Patients were treated with external beam radiotherapy (ERBT) with doses ranging from 30 to 60 Gy (with a median daily dose of 2 Gy) or intracavitary brachytherapy (ICBT) with 30 Gy (with a median daily dose of 15 Gy). The follow‐up examinations after RT were conducted by gynecologic oncologists with or without radiation oncologists in an outpatient clinic, as reported previously . Briefly, the patients were followed up every month in the 1st year, every 2 months in the 2nd year, every 3 months in the 3rd year, every 4 months in the 4th year, every 6 months in the fifth year, and annually thereafter until 10 years after treatment.…”

“…The follow-up examinations after RT were conducted by gynecologic oncologists with or without radiation oncologists in an outpatient clinic, as reported previously. 9 Briefly, the patients were followed up every month in the 1st year, every 2 months in the 2nd year, every 3 months in the 3rd year, every 4 months in the 4th year, every 6 months in the fifth year, and annually thereafter until 10 years after treatment. The standard follow-up surveillance program consisted of a clinical history, physical examination and a complete blood analysis including tumor markers.…”

Radical hysterectomy after radiotherapy for recurrent or persistent cervical cancer

“…Despite considerable effort during recent decades to improve patient survival follow radiotherapy, recurrent cervical cancer is a difficult clinical problem . Further radiotherapy could be a curative option for a highly select group of these patients . However, re‐irradiation has been employed sparingly owing to concerns regarding severe late toxicities.…”