Reinforced chitosan membranes by microspheres for guided bone regeneration

Preparation and characterization of chitosan membranes

“…[4][5][6][7] Many studies have reported that chitosan has an excellent ability to form microspheres, membranes and bers, which gives it a signicant advantage over other absorbable membrane materials in the design of packaging structures. 8 However, chitosan is generally prepared using acetic acid as solventa method that brings a number of disadvantages, such as minimal thickness, peculiar smell and fragile nature of the lms at low concentration of chitosan, as well as easy drying and curl. Therefore, it is necessary to nd an alternative dissolution medium for chitosan.…”

Incorporation of simvastatin in PLLA membranes for guided bone regeneration: effect of thermal treatment on simvastatin release

“…8 Different strategies can be adopted to overcome these drawbacks. The development of new materials based on polymeric composites 5,9 or graphene/graphene oxide composites 10,11 are promising approaches, leading to the proliferation and osteogenic differentiation of osteoblastic cells. An alternative strategy is the incorporation of osteostimulatory compounds.…”

A review of chitosan-, alginate-, and gelatin-based biocomposites for bone tissue engineering

“…On the membranes with chitosanhydroxyapatite microspheres, the number of cells attached and the filopodia extensions were higher compared with the simple chitosan microsphere membranes. Thus, the results indicate that these types of composite membranes could be suitable for bone defects regeneration (Huang et al, 2018).…”

“…The above-mentioned results are summarized in Table 4. hydroxyapatite-chitosan enhanced bioactivity, osteoblast differentiation and antibacterial properties, improved MC3T3 cells viability, pre-osteoblast attachment, and pseudopodia expansion; (Zima, 2018, Jahan et al, 2019 polycaprolactone-CMC enhanced MG-63 cell attachment and proliferation (Sharifi et al, 2018) chitosan-hydroxyapatite-resol improved metabolic activity, ALP activity, and protein adsorption for MG-63 cells and stimulated angiogenesis, enhanced osteogenic activity, and bioactivity in Albino rats (Shakir et al, 2018) chitosan-zirconium oxide/calcium zirconate/hydroxyapatite improved compressive strength and proliferation of OB-6 pre-osteoblasts (Gaihre and Jayasuriya, 2018) poly(L-lactic acid)-chitosan enhanced proliferation of mBMSCs and improved ALP activity; improved new bone formation in Sprague-Dawley rats (Chen et al, 2018) Incorporated chitosanhydroxyapatite microspheres into chitosan membranes enhanced MG63 attachment (Huang et al, 2018) 4.2. Alginate-based biomaterials…”