Rehabilitation of therapy-related cognitive deficits in patients after hematopoietic stem cell transplantation

Poppelreuter, Martin; Weis, Joachim; Mumm, A.; Orth, H B; Bartsch, Hans Helge

doi:10.1038/sj.bmt.1705884

Cited by 43 publications

(47 citation statements)

References 36 publications

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“…Da sich einerseits Umfang und Qualität adjuvanter chemotherapeutischer Strategien in den letzten Jahren deutlich verändert haben und andererseits dank verbesserter supportiver Maßnahmen auch ältere Patienten intensivster Hochdosisprotokolle unterzogen werden, hat die Relevanz neuropsychologischer Folgestörungen aber erheblich zugenommen. Allerdings wird der mögliche Einfluss chemotherapeutischer Strategien sowohl in üblicher Dosierung (wie beim Mammakarzinom) [27,28] als auch bei der Hochdosistherapie mit nachfolgender Stammzelltransplantation [29,30] auf kognitive Leistungen auch kontrovers diskutiert. Zumindest kann das eindimensionale Modell der Schädigung bestimmter Hirnareale durch ein oder mehrere Pharmaka die in manchen Studien von bis zu zwei Drittel der Patienten erlebten Defizite allein wohl nicht erklären.…”

Section: Kognitive Folgeproblemeunclassified

Psychosoziale Folgen bei Langzeitüberlebenden einer Krebserkrankung

Weis

Faller

2012

Bundesgesundheitsbl.

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Although cancer incidence rates are increasing, recent statistical studies suggest that cancer patients are showing higher cure rates as well as improved overall survival rates for most cancer locations. These advances are explained by improved strategies in early diagnoses as well as improved cancer therapies. Therefore, the number of long-term cancer survivors has also increased, but only few studies, especially within the last years, have focused on psychosocial issues of this subgroup. Some studies show that overall quality of life of long-term cancer survivors is quite high and comparable to that of the normal population. Nevertheless, a substantial percentage of former patients shows reduced quality of life and suffers from various sequelae of cancer and its treatment. This review focuses on the most common psychosocial issue of long-term survivors such as reduced psychological wellbeing, neuropsychological deficits and cancer-related fatigue syndrome. Finally, recommendations for problem-oriented interventions as well as improvement of psychosocial care of long-term survivors are given.

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Section: Kognitive Folgeproblemeunclassified

Psychosoziale Folgen bei Langzeitüberlebenden einer Krebserkrankung

Weis

Faller

2012

Bundesgesundheitsbl.

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“…Erst in den letzten Jahren deutlicher identifizierbar sind spezifische kognitiv-neuropsychologisch intellektuelle Defizite im Sinne von Konzentrationsstörungen, sowie Einschränkungen der Merk-und Gedächt-nisfunktion. Bei diesen Störungen sind vorangegangene Tumortherapien (Chemotherapie, Radiatio) kausal anzuschuldigen [24,25,26].…”

Section: Psychosoziale Belastungenhäufig Verkanntunclassified

Rehabilitation onkologischer Patienten

Bartsch

2009

best practice onkologie

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Die Rehabilitation ist für zahlreiche Patienten nach einer Primärtumortherapie, aber auch für Patienten in palliativen Erkrankungssituationen von Wichtigkeit und nachhaltigem Nutzen. Die Charakterisierung eines Rehabilitationsbedarfs und eine auf die individuelle Situation zugeschnittene Rehabilitationsstrategieambulant oder stationär -sind unabdingbare Vorraussetzung für den Erfolg. Der Beitrag gibt einen Überblick zu Rehabilitationsmaßnahmen für onkologische Patienten und worauf hierbei zu achten ist. 36

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“…Neuro-cognitive deficits are potential side effects of hematopoietic SCT (HSCT). A substantial number of patients revealed evidence of cognitive deficits a long time after HSCT [33]. Many researches in functional neurosurgery are associated with cognitive mapping system.…”

Section: Importance Of Neuro-cognitive Assessment and Rehabilitation mentioning

confidence: 99%

“…Central axons that myelinated by the Schwann cells have been found, but it may either be remyelinated (the same so that is described above), or possibly central axons are made to be regenerated by Schwann cells. In this final stage, the lesion is more or less static except when it is supposed that continuous increase in the loss of Wallerian degeneration of spinal tracts occur above or below the lesion and this can effect on the plasticity of neuronal synaptic network [18,[28][29][30][31][32][33][34][35][36]. Neural changes in chronic phase included: inappropriate amounts of gliosis, collagen, new blood vessels, macrophages, cellular migration and reproduction, irregular heteromorphic networks, collagenous fibrosis, remyelinization, regeneration, degeneration of Wallerian axons and effect on the plasticity of neuronal synaptic network.…”

Section: Neural Changes In Sci Stagesmentioning

confidence: 99%

Neuro-cognitive rehabilitation among patients with spinal cord injury treated with stem cell

Zarghi¹,

Zali²,

Ashrafi³

et al. 2014

Neurosci Discov

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Discovery of the potential use of stem cells in neural repair and regeneration on patients with Spinal cord injury (SCI) is a noteworthy development in the neurosciences. In this review, several ongoing studies are presented that aim to describe neurobiology of spinal cord injury, role of stem cell therapy in neural repair and importance of neuro-cognitive rehabilitation (NCR) among patients with SCI who treated with stem cell. Result: NCR is a group of designed techniques that is for the promotion of cognitive domains. It is a science of restoring cognitive processing which affects the molecular and cellular recovery rehabilitation by integrating behavioral and cognitive changes. Neuro-cognitive deficits are potential side effects of stem cell therapy (SCT). The promotion of cognitive neuroscience rehabilitation has made it a priority with the help of interventional procedures. Cognitive impairments after SCT in patients with SCI are considered huge health challenges. Intervention in the passive skills also can lead to NCR that includes designed experience on the basis of nerve and brain function and structure. Neuroplasticity and reorganization of cortical damage by morphological and physiological reactions in nerve reconstruction techniques are the basis of neuro-cognitive rehabilitation which is affected by the environment, stimulation complexity, repeated tasks and motivation.

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Rehabilitation of therapy-related cognitive deficits in patients after hematopoietic stem cell transplantation

Cited by 43 publications

References 36 publications

Psychosoziale Folgen bei Langzeitüberlebenden einer Krebserkrankung

Psychosoziale Folgen bei Langzeitüberlebenden einer Krebserkrankung

Rehabilitation onkologischer Patienten

Neuro-cognitive rehabilitation among patients with spinal cord injury treated with stem cell

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