Rehabilitation for patients with myalgic encephalomyelitis/chronic fatigue syndrome: time to extent the boundaries of this field

Nijs, Jo; Malfliet, Anneleen

doi:10.1111/joim.12431

Cited by 3 publications

(3 citation statements)

References 23 publications

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“…Particularly, where neuroinflammation, and therefore, central sensitization exists. Previous attempts to classify patients with CPLBP according to pain mechanisms suggested three subgroups: nociceptive, neuropathic, and central sensitization pain (Smart et al, 2012;Nijs et al, 2015). However, there is no consensus on the clinical methods that can accurately discriminate between pain mechanisms.…”

Section: Discussionmentioning

confidence: 99%

Urinary TNF-α as a potential biomarker for chronic primary low back pain

Gevers-Montoro,

Puente-Tobares,

Monréal

et al. 2023

Front. Integr. Neurosci.

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IntroductionOver two thirds of individuals with low back pain (LBP) may experience recurrent or persistent symptoms in the long term. Yet, current data do not allow to predict who will develop chronic low back pain and who will recover from an acute episode. Elevated serum levels of the proinflammatory cytokine tumor necrosis factor-α (TNF-α) have been associated with poor recovery and persistent pain following an acute episode of LBP. Inflammatory cytokines may also mediate mechanisms involved in nociplastic pain, and thus, have significant implications in chronic primary low back pain (CPLBP).MethodsThis study aimed to investigate the potential of urinary TNF-α levels for predicting outcomes and characterizing clinical features of CPLBP patients. Twenty-four patients with CPLBP and 24 sex- and age-matched asymptomatic controls were recruited. Urinary TNF-α concentrations were measured at baseline and after 4 weeks, during which CPLBP patients underwent spinal manipulative therapy (SMT).ResultsConcentrations of TNF-α were found to be elevated in baseline urine samples of CPLBP patients compared to asymptomatic controls. Moreover, these values differed among patients depending on their pain trajectory. Patients with persistent pain showed higher levels of TNF-α, when compared to those with episodic CPLBP. Furthermore, baseline TNF-α concentrations and their changes after 4 weeks predicted alterations in pain intensity and disability following SMT in patients with CPLBP.DiscussionThese findings warrant further research on the potential use of urinary TNF-α concentrations as a prognostic biomarker for CPLBP.

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Section: Discussionmentioning

confidence: 99%

Urinary TNF-α as a potential biomarker for chronic primary low back pain

Gevers-Montoro,

Puente-Tobares,

Monréal

et al. 2023

Front. Integr. Neurosci.

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“…Unsurprisingly, in light of the above findings, it has recently been suggested that rehabilitation for CFS/ME/SEID patients should be extended from a narrow psychologically based domain and become multidisciplinary, including for example exercise physiologists and physiotherapists [ 115 ].…”

Section: Treatmentmentioning

confidence: 99%

A Molecular Neurobiological Approach to Understanding the Aetiology of Chronic Fatigue Syndrome (Myalgic Encephalomyelitis or Systemic Exertion Intolerance Disease) with Treatment Implications

Monro¹,

Puri

2018

Mol Neurobiol

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Currently, a psychologically based model is widely held to be the basis for the aetiology and treatment of chronic fatigue syndrome (CFS)/myalgic encephalomyelitis (ME)/systemic exertion intolerance disease (SEID). However, an alternative, molecular neurobiological approach is possible and in this paper evidence demonstrating a biological aetiology for CFS/ME/SEID is adduced from a study of the history of the disease and a consideration of the role of the following in this disease: nitric oxide and peroxynitrite, oxidative and nitrosative stress, the blood–brain barrier and intestinal permeability, cytokines and infections, metabolism, structural and chemical brain changes, neurophysiological changes and calcium ion mobilisation. Evidence is also detailed for biologically based potential therapeutic options, including: nutritional supplementation, for example in order to downregulate the nitric oxide-peroxynitrite cycle to prevent its perpetuation; antiviral therapy; and monoclonal antibody treatment. It is concluded that there is strong evidence of a molecular neurobiological aetiology, and so it is suggested that biologically based therapeutic interventions should constitute a focus for future research into CFS/ME/SEID.

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“…Fear of movement and avoidance behaviour towards physical activity has been reported in CFS/ME and other fatigue associated conditions (Nijs et al, 2012;Vergauwen et al, 2015). Activity avoidance has been related to various clinical characteristics of CFS/ME, including symptom severity, reduced quality of life and disability (Vergauwen et al, 2015;Scerbo et al, 2017;Nijs and Malfliet, 2016). When seeing patients with CFS/ME it is crucial to identify movement behaviour, be it persisting, avoiding or boom and busting.…”

Section: Avoidance Of Movementmentioning

confidence: 99%

Managing fatigue in postural tachycardia syndrome (PoTS): The Newcastle approach

Strassheim

Welford

Ballantine

et al. 2018

Autonomic Neuroscience

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Fatigue is a significant symptom that is frequently reported by those with postural tachycardia syndrome (PoTS). There are a variety of reasons why those with PoTS might experience fatigue and as a consequence an individualised approach to management is most appropriate. In this chapter we will examine the prevalence of fatigue in those with PoTS, its overlap with conditions such as chronic fatigue syndrome and describe a clinical approach to the management of fatigue in those with PoTS.

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Rehabilitation for patients with myalgic encephalomyelitis/chronic fatigue syndrome: time to extent the boundaries of this field

Abstract: http://onlinelibrary.wiley.com/doi/10.1111/joim.12402/abstract

Cited by 3 publications

References 23 publications

Urinary TNF-α as a potential biomarker for chronic primary low back pain

Urinary TNF-α as a potential biomarker for chronic primary low back pain

A Molecular Neurobiological Approach to Understanding the Aetiology of Chronic Fatigue Syndrome (Myalgic Encephalomyelitis or Systemic Exertion Intolerance Disease) with Treatment Implications

Managing fatigue in postural tachycardia syndrome (PoTS): The Newcastle approach

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