2018
DOI: 10.1007/s12035-018-0928-9
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A Molecular Neurobiological Approach to Understanding the Aetiology of Chronic Fatigue Syndrome (Myalgic Encephalomyelitis or Systemic Exertion Intolerance Disease) with Treatment Implications

Abstract: Currently, a psychologically based model is widely held to be the basis for the aetiology and treatment of chronic fatigue syndrome (CFS)/myalgic encephalomyelitis (ME)/systemic exertion intolerance disease (SEID). However, an alternative, molecular neurobiological approach is possible and in this paper evidence demonstrating a biological aetiology for CFS/ME/SEID is adduced from a study of the history of the disease and a consideration of the role of the following in this disease: nitric oxide and peroxynitri… Show more

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Cited by 34 publications
(33 citation statements)
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“…Myalgic encephalomyelitis/chronic fatigue syndrome (ME/ CFS) is defined by the original diagnostic criteria (Fukuda et al, 1994) and by the Canadian Consensus Criteria (Carruthers et al, 2003;Carruthers, 2007), followed by an international consensus (Carruthers et al, 2011) and newer clinical diagnostic criteria developed by a National Institutes of Health Pathways to Prevention Workshop (Haney et al, 2015) and the Institute of Medicine (Germain et al, 2017). ME/CFS has also been known by other names (Unger et al, 2016), most recently as systemic exertion intolerance disease (Monro and Puri, 2018). ME/CFS is a complex disease that involves the muscular, nervous, hormonal, and immune systems (Natelson, 2001;Georgiades et al, 2003;Brurberg et al, 2014;Brigden et al, 2017;Scheibenbogen et al, 2017).…”
Section: Introductionmentioning
confidence: 99%
“…Myalgic encephalomyelitis/chronic fatigue syndrome (ME/ CFS) is defined by the original diagnostic criteria (Fukuda et al, 1994) and by the Canadian Consensus Criteria (Carruthers et al, 2003;Carruthers, 2007), followed by an international consensus (Carruthers et al, 2011) and newer clinical diagnostic criteria developed by a National Institutes of Health Pathways to Prevention Workshop (Haney et al, 2015) and the Institute of Medicine (Germain et al, 2017). ME/CFS has also been known by other names (Unger et al, 2016), most recently as systemic exertion intolerance disease (Monro and Puri, 2018). ME/CFS is a complex disease that involves the muscular, nervous, hormonal, and immune systems (Natelson, 2001;Georgiades et al, 2003;Brurberg et al, 2014;Brigden et al, 2017;Scheibenbogen et al, 2017).…”
Section: Introductionmentioning
confidence: 99%
“…1 There was plenty of literature available, especially more recently, which added growing support for a neuro-inflammatory concept to explain ME/CFS. 5,6 Most of the evidence involved either brain scanning techniques [7][8][9][10][11] or cerebrospinal fluid studies of ME/CFS patients, [12][13][14][15] but it was evident that the brain scanning technology being used was simply not sophisticated enough to detect chronic and fluctuating inflammation in the brains of ME/CFS patients that mirrored the chronic and fluctuating symptoms described above.…”
Section: Making Sense Of My Conditionmentioning
confidence: 99%
“…There is a growing body of evidence on biological abnormalities in ME/CFS that have been reviewed elsewhere (Edwards et al, 2016;Monro and Puri, 2018;Shepherd and Chaudhuri, 2019), and summarised by Komaroff (2019). Of note, many of the abnormalities shown in severe injury have also been identified in ME/CFS such as: immune dysfunction, including pro-inflammatory response (especially at early stages of disease) (Cliff et al, 2019;Lord et al, 2014); autonomic nervous system (Cambras et al, 2018;Esterov and Greenwald, 2017;Oosterwijck et al, 2017); HPA axis dysfunction (Tomas et al, 2013); hypovolemia (van Campen et al, 2018); nitrosamine and oxidative stress (Newton et al, 2012); endothelial dysfunction (Newton et al, 2012); metabolic dysfunction (Germain et al, 2018); dysfunction of membrane transport ; and, tissue hypoxia (Vermeulen and Vermeulen van Eck, 2014).…”
Section: Evidence Of Abnormalities In Me/cfs and Loss Of Normal Homeomentioning
confidence: 99%
“…For example, gender-and age-specific factors are thought to contribute to the risk of ME/CFS (Bakken et al, 2014), with epidemiological studies consistently reporting higher rates of the disease in females (Nacul et al, 2011;Prins et al, 2006). Although most cases are endemic, there have been reports of epidemic cases, which suggest infectious or another environmental cases have a role (Levine et al, 1992(Levine et al, , 1997Monro and Puri, 2018;Naess et al, 2012). Cases are predominantly reported in North America, Europe and Oceania; however, the occurrence of ME/CFS is thought to be global with evidence of cases in other parts of the world (Cho et al, 2009;Nacul et al, 1999;Njoku et al, 2007).…”
Section: Predisposition and Triggering Of Diseasementioning
confidence: 99%
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