Rehabilitating a brain with Alzheimer's: a proposal

Abstract

Alzheimer’s disease (AD) is the most common neurodegenerative disorder, originating sporadically in the population aged over 65 years, and advanced age is the principal risk factor leading to AD development. In spite of the large amount of research going on around the globe and all the information now available about AD, there is still no origin or triggering process known so far. Drugs approved for the treatment of AD include tacrine, donepezil, rivastigmine, galantamine, and memantine. These may delay or slow down the degenerative process for a while, but they can neither stop nor reverse its progression. Because that this might be due to a lack of effect of these drugs on degenerating neurons, even when they are able to potentiate the brain in nondegenerative conditions, we propose here an alternative therapy consisting of initial repair of neuronal membranes followed by conventional drug therapies. The rehabilitation of neurons in a degeneration process would enable the drugs to act more effectively on them and improve the effects of treatment in AD patients.

Validation of the General Practitioner Assessment of Cognition – Chinese version (GPCOG-C) in China

“…The early detection of cognitive decline can help patients and families prepare for the future, and assist clinicians to identify patients at risks for delirium or driving mishaps (Molnar et al, 2006;Alagiakrishnan et al, 2007). Early detection also provides an opportunity for treat-ment to improve function, behavior, and cognition (Aranda-Abreu et al, 2011). In this context, cognitive screening represents an initial step in the process of further assessment for dementia and can help in identifying potential cases for management.…”

Protective effect of rutin on cognitive impairment caused by phenytoin

“…The mechanism by which PIM shows its nootropic effect is still under research scholars’ consideration and same is the case with rutin. For PIM, a number of mechanisms have been advocated such as an enhancement of oxidative glycolysis,[ 21 ] an effect on the Ca 2+ channels,[ 22 ] and an effect on the cholinergic system,[ 21 ] but in case of rutin, no such supportive data is available except for oxidative glycolysis[ 23 ] some data also says for its involvement in cholinergic system. The latter is important in the process of learning and memory.…”

A Review: Pharmacological and herbal remedies in The Management of Neurodegenerative disorder (Alzheimer’s)

“…Tacrine is widely absorbed after oral administration, half-life is upto 70hours also it is used in all the stages of AD. It shows few side effects such as nausea, diarrhea, anorexia [45,46] .…”