Protective effect of rutin on cognitive impairment caused by phenytoin

Abstract

Objective:To study the effect of the co-administration of phenytoin (PHT) and rutin in comparison with PHT and piracetam (PIM) on seizure control, cognitive, and motor functions in mice.Materials and Methods:Increasing current electroshock seizure (ICES) test was used to evaluate the effect of the co-administration of PHT and PIM on convulsions. Cognitive functions in mice were assessed by a spontaneous alternation in behavior on a plus maze while motor functions were screened using rolling roller apparatus and by counting the number of arms entries on a plus maze. Brain acetyl-cholinesterase (AChE) activity was also estimated.Statistical Analysis:The expression of data was done as mean ± standard error of the mean. The normally distributed data were subjected to one-way ANOVA followed by Dunnett's test. P < 0.05 was considered significant.Results:The study showed that rutin when co-administered with PHT, significantly reversed PHT-induced reduction in spontaneous alternation without altering the efficacy of PHT against ICES, in both acute and chronic studies. Further, it also reversed PHT-induced increase in AChE activity.Conclusion:Rutin alleviated the PHT-induced cognitive impairment without compromising its antiepileptic efficacy.

SlMYB12 Regulates Flavonol Synthesis in Three Different Cherry Tomato Varieties

“…Rutin, which scavenges free radicals in organisms, has potential anti-inflammatory, anticarcinogenic, and antimicrobial effects by suppressing cellular immunity 8 – 11 . A previous study has demonstrated that rutin also has an effect on regulating the brain cholinergic system when co-administered with priacetam and phenytoin 12 . Apart from these, rutin shows an ability to control brain neurotransmitters and protect against heart disease 13 , 14 .…”

Protective Effect of Rutin on Cognition Impairment Caused by Levetiracetam.

“…Higher dosages of PIM have demonstrated a strong antiepileptic impact against ICES (26) as well as substantial nootropic effects on the MES model (7). Another well-known flavonoid is rutin, which has nootropic properties (19)(20)(21)(22)(23)(24)(25).Therefore, the goal of this investigation was to convince the effect. Thus in this study it was intended to persuade the effect of co administration of PIM and Rutin with a clinically established AED in antiepileptic therapy.…”