Regulatory T cells in the actinic cheilitis

Gasparoto, Thaís Helena; Malaspina, Tatiana Salles de Souza; Damante, José Humberto; Mello, Edgard Franco de; Ikoma, Maura Rosane Valério; Garlet, Gustavo; Costa, Maria Renata Sales Nogueira; Cavassani, Karen A.; Silva, João; Campanelli, Ana Paula

doi:10.1111/jop.12207

Cited by 10 publications

(18 citation statements)

References 47 publications

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“…The immunosuppressive activity of this subpopulation of T cells may be particularly necessary in the early stages of lip carcinogenesis, in which neoplastic cells are possibly more immunogenic. As observed in this study, early-stage LLSCCs are low-grade tumors 24 demonstrated the accumulation of functional Treg cells (CD4+CD25+FoxP3+) in actinic cheilitis. Furthermore, enzyme-linked immunosorbent assays (ELISA) revealed higher expression levels of IL-10 and TGF-β and lower levels of interferon gamma (IFN-γ) in actinic cheilitis when compared to the control group (healthy gingival tissue).…”

Section: 15supporting

confidence: 74%

“…Furthermore, enzyme-linked immunosorbent assays (ELISA) revealed higher expression levels of IL-10 and TGF-β and lower levels of interferon gamma (IFN-γ) in actinic cheilitis when compared to the control group (healthy gingival tissue). According to Gasparoto et al, 24 the accumulation of functional Treg cells in actinic cheilitis may inhibit the proliferation of T cells and produce a microenvironment with high levels of immunosuppressive cytokines, events that contribute to the persistence, recurrence, progression, and malignant transformation of these lesions.…”

Section: 15mentioning

confidence: 99%

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Immunohistochemical analysis of FoxP3+ regulatory T cells in lower lip squamous cell carcinomas

et al. 2016

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The aim of this study was to determine the number of FoxP3+ regulatory T (Treg) cells in the microenvironment of lower lip squamous cell carcinomas (LLSCCs) and to correlate the findings with clinicopathological parameters (tumor size/extent, regional lymph node metastasis, clinical stage, and histopathological grade of malignancy). Fifty cases of LLSCC were selected. Lymphocytes exhibiting nuclear immunostaining for FoxP3 were quantified in 10 microscopic fields at the deep invasive front of LLSCCs. The results were analyzed statistically using the nonparametric Mann-Whitney test and Fisher's exact test. FoxP3+ lymphocytes were observed in all cases studied. The number of these cells tended to be higher in smaller tumors, tumors without regional lymph node metastasis, and tumors in early clinical stages, but the difference was not statistically significant (p > 0.05). Low-grade tumors contained a larger number of

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Section: 15supporting

confidence: 74%

Section: 15mentioning

confidence: 99%

Immunohistochemical analysis of FoxP3+ regulatory T cells in lower lip squamous cell carcinomas

et al. 2016

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“…11,12 The establishment of an immunosuppressive environment could be an early event in lip carcinogenesis. In line with this suggestion, Gasparoto et al 33 demonstrated the accumulation of functional T regulatory cells (CD4+CD25+FoxP3+) in actinic cheilitis, which is characterized by potentially malignant lesions that can progress to SCCLL. These authors also observed higher expression of IL-10 and TGF-β and lower expression of IFN-γ in actinic cheilitis when compared to the control group (healthy gingival tissue).…”

Section: Discussionmentioning

confidence: 76%

“…These authors also observed higher expression of IL-10 and TGF-β and lower expression of IFN-γ in actinic cheilitis when compared to the control group (healthy gingival tissue). 33 These findings suggest the existence of a mutually reinforcing cytokine signal network between M2 TAMs and T regulatory cells in early stages of lip carcinogenesis.…”

Section: Discussionmentioning

confidence: 80%

Tumor-associated macrophages (TAMs): clinical-pathological parameters in squamous cell carcinomas of the lower lip

et al. 2016

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The objective of this study was to analyze the presence of tumor-associated macrophage (TAM) subpopulations M1 and M2 in squamous cell carcinoma of the lower lip (SCCLL) by immunohistochemitry, and to evaluate the possible role of these subtypes in the development of regional lymph node metastasis and their association with clinical and pathological parameters. Forty-two cases of SCCLL were divided into two groups (21 with and 21 without regional lymph node metastasis). The histopathological grade of malignancy was determined and the material was submitted to double staining with anti-CD68/anti-CD163 and anti-CD68/anti-HLA-DR monoclonal antibodies. The results were analyzed statistically using the Wilcoxon signed-rank and Spearman correlation tests. The M1 and M2 subpopulations were observed in all cases studied. No significant difference was observed between the quantities of M1 and M2 TAMs regarding tumor size (p > 0.05). A significantly larger number of M2 compared to M1 TAMs was observed in tumors without regional lymph node metastasis, tumors in early stages, and low-grade tumors (p < 0.05). No significant difference between the numbers of M1 and M2 TAMs was observed in tumors with regional lymph node metastasis, tumors in advanced stages, and high-grade tumors (p > 0.05). There was a positive weak correlation between M1 and M2 TAMs (r = 0.361; p = 0.019). The results suggest a more important role of M2 TAMs in early stages than advanced stages of lip carcinogenesis. The progression of SCCLL does not seem to be related to an imbalance of macrophage polarization in the microenvironment of these tumors.

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“…Причины акти-нического хейлита -длительное и интенсивное солнеч-ное облучение в сочетании с метеорологическими факто-рами (постоянная работа на открытом воздухе, ветер, мо-роз) [12,78]. Довольно часто актинический хейлит наблю-дается у пациентов совместно с другими аллергическими состояниями типа солнечного пруриго (эритема на коже лица) [55].…”

Section: стоматология 1 2016unclassified

Clinical and pathogenetic aspects of various forms of cheilitis

Rabinovich

Abramova

et al. 2016

Stomat.

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Заболевания губ встречаются сравнительно часто. Находясь под постоянным воздействием внешних и вну-тренних факторов, слизистая оболочка и красная кайма губ могут подвергаться воспалительным процессам, пре-терпевая различные трансформации, что, в свою очередь, приводит к значительным затруднениям при постановке диагноза. Воспаление красной каймы, слизистой оболоч-ки и кожи вокруг губ называется хейлитом (cheilitis). Этиология, патогенез и клиника различных форм хейлитаОстановимся только на наиболее встречающихся в клинике формах хейлита.Экзематозный хейлит (cheilitis eczematosis). Основной его причиной следует считать аллергический фактор. В качестве аллергенов могут выступать различные микро-бы, в первую очередь -пиококки, вызывающие хрониче-ские трещины губ. Грибы рода Candida в отдельных случа-ях служат сенсибилизатором, поддерживающим, а иногда вызывающим экзему губ. Химические вещества (губные помады, протезы, некоторые лекарственные препараты) также могут способствовать ее развитию. Проявление ги-повитаминоза, в первую очередь -арибофлавиноза, под-час напоминают экзему губ [11,53].Экзематозный хейлит может быть как острым, так и хроническим. Острое его течение характеризуется яркой гиперемией губ и окружающей кожи, отеком и появлени-ем пузырьков, мелких трещин, кровянистых и желтовато-го цвета корочек; возможно появление участков мокну-тия. В случаях длительного течения экзематозного хейли-та при микробиологическом анализе высеиваются стреп-тококки, послужившие дополнительным аллергеном при экземе. При хроническом течении отмечаются отек губ, застойная гиперемия, в углах рта образуются трещины,

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Regulatory T cells in the actinic cheilitis

Abstract: Therefore, our data show that Tregs accumulate in AC lesions, and these cells could be suppressing immune responses in a potentially malignant microenvironment.

Cited by 10 publications

References 47 publications

Immunohistochemical analysis of FoxP3+ regulatory T cells in lower lip squamous cell carcinomas

Immunohistochemical analysis of FoxP3+ regulatory T cells in lower lip squamous cell carcinomas

Tumor-associated macrophages (TAMs): clinical-pathological parameters in squamous cell carcinomas of the lower lip

Clinical and pathogenetic aspects of various forms of cheilitis

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