Clinical and pathogenetic aspects of various forms of cheilitis

РЕЗЮМЕ Обоснование. Число мужчин и женщин с гастроэзофагеальной рефлюксной болезнью (ГЭРБ) с каждым годом растет; кроме того, эта болезнь стремится к омоложению. В связи с тем что полость рта является начальным отделом пищеварительной системы, заболевания желудочно-кишечного тракта (ЖКТ) и соответствующие изменения в полости рта тесно взаимосвязаны. Цель исследования-оценка стоматологического статуса пациентов с ГЭРБ в зависимости от приема ингибиторов протонной помпы на основании комплексного клинико-лабораторного исследования. Материал и методы. В исследовании приняли участие 100 человек в возрасте 35-65 лет, которые были распределены на три группы: 1-я (контрольная)-30 человек; 2-я-35 пациентов с ГЭРБ, не принимающих ингибиторы протонной помпы, 3-я-35 пациентов с ГЭРБ, принимающих ингибиторы протонной помпы. Для выявления пациентов, имеющих предрасположенность к ГЭРБ, все участники исследования отвечали на опросник Gastroesophageal Reflux Disease Questionnaire (GRDQ). Если итоговая оценка была больше 8 баллов, пациента направляли на консультацию к гастроэнтерологу. Для оценки стоматологического статуса пациентов определяли индекс КПУ, пародонтальный индекс PI, измеряли рН слюны, а также использовали метод полимеразной цепной реакции для определения качественного и количественного состава пародонтопатогенов. Итоговая оценка по опроснику GRDQ у 2-й группы была значительно выше, чем у пациентов 1-й и 3-й групп. В ходе исследования выявлены высокая интенсивность кариеса, ухудшение паpодонтального и гигиенического статусов, высокая распространенность пародонтопатогенов Porphyromonas gingivalis, Prevotella intermedia и Actinobaccilus actinomecetemcomitans у пациентов 2-й группы по сравнению с пациентами 3-й и контрольной групп. Выводы. Результаты исследования продемонстрировали снижение рН смешанной слюны во 2-й группе. Стоматологический статус у пациентов на фоне ГЭРБ ухудшается. Ключевые слова: гастроэзофагеальная рефлюксная болезнь (ГЭРБ), пародонтит, ПЦР (полимеразная цепная реакция), стоматологический статус, ингибиторы протонной помпы.

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The dental status of patients with gastroesophageal reflux disease depending on the intake of proton pump inhibitors

Sazanskaya

Gulua

Gilmiyarov

et al. 2020

Stomat.

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Cheilitis. A Modern View of the Problem

Uspenskaya¹,

Спиридонова

Syurnyaeva

et al. 2022

Actual Problems in Dentistry

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Subject. A review of the literature devoted to one of the urgent problems of therapeutic dentistry — lip diseases. Objectives. Analysis of up-to-date information on lip diseases. Synthesis of the obtained data in a single concept. Methodology. The data of special literature were studied using scientific search library databases: PubMed, Elibrary, Cochrane, Google Scholar. Literature analysis was carried out on 45 sources. Results. In the modern world, diseases of the oral mucosa are widespread, among them lip diseases have a significant prevalence, many of which are insufficiently studied. Attempts have been repeatedly made to create a classification of heilites, however, as various authors note, there is no universally recognized classification today. The modern standard is the classification of ICD-10. Foreign researchers Kristina Pilipovich, Iva Crnarich, Mirna Shitum, Tomislav Duvanchich propose a new classification with the division of cheilitis into three groups (mainly reversible; mainly persistent; cheilitis associated with dermatoses or general somatic diseases). The special literature describes many aspects inherent in various types of cheilites. The modern direction of treatment of cheilitis is an integrated approach based on the joint implementation of general and local measures. Conclusions. To date, there is no universal treatment regimen for lip diseases, but many authors agree on the need to implement a combined treatment. This option with the use of different groups of drugs ensures the achievement of an effective result.

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Etiopathogenetic Aspects of Meteorological Cheilitis in the Extreme North

E.G.

L.I.

2022

Mediko-farmacevtičeskij žurnal "Pulʹs"

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Traumatization of the lips by adverse meteorological conditions during the cold season predisposes to the development of meteorological cheilitis, which is often ignored by doctors. The diagnosis can be complicated by the addition of an infectious agent against the background of a chronic violation of the integrity of the tissues, and with a long course it can turn into obligate forms of precancerous diseases of the lips. In the development of meteorological cheilitis in residents of the Far North, a special role is played by "polar" metabolism and a weakened antioxidant defense of the body, which is the most important link in the pathogenetic mechanism for the development of meteorological cheilitis in the population. The purpose of this study is to improve the system of diagnosis and treatment of meteorological cheilitis, taking into account etiopathogenetic features. Material and methods. The study included patients with a confirmed diagnosis of meteorological cheilitis without a burdened anamnesis. After collecting an anamnesis, examination, general and local therapy was prescribed. Before and after treatment, a biochemical study of the content of vitamins A, E, D in the blood serum was carried out. Results and discussion. An analysis of the content of vitamin D before treatment indicates a low level of vitamin D in more than 50% of the subjects, the results of the remaining patients are in the range of the lower limit of the reference values. The content of vitamins A and E in the serum of venous blood is in the acceptable range. 2 months after treatment, the content of vitamin D in the blood serum of all patients rose to normal levels. Conclusions. Complex local and general therapy led to the neutralization of the clinical manifestations of meteorological cheilitis in 100% of patients. A scheme for the prevention of meteorological cheilitis in residents in adverse climatic conditions has been developed.

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Clinical and pathogenetic aspects of various forms of cheilitis

Cited by 4 publications

References 32 publications

The dental status of patients with gastroesophageal reflux disease depending on the intake of proton pump inhibitors

The dental status of patients with gastroesophageal reflux disease depending on the intake of proton pump inhibitors

Cheilitis. A Modern View of the Problem

Etiopathogenetic Aspects of Meteorological Cheilitis in the Extreme North

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