Regulatory T-cell dysfunction induces autoantibodies to bullous pemphigoid antigens in mice and human subjects

Muramatsu, Ken; Ujiie, Hideyuki; Kobayashi, Ichiro; Nishie, Wataru; Izumi, Kiyotaka; Ito, Takamasa; Yoshimoto, Norihiro; Natsuga, Ken; Iwata, Hiroaki; Shimizu, Hiroshi

doi:10.1016/j.jaci.2018.03.014

Cited by 67 publications

(69 citation statements)

References 60 publications

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“… and Muramatsu et al. also successfully illuminated the pathogenic function of anti‐BP230 IgG autoantibodies. They demonstrated that in scurfy mice whose regulatory T cells (Treg) were defective ( Foxp 3 mutation), there was spontaneous production of IgG1 autoantibodies to BP230.…”

Section: In Vivo Studies Of Autoantibodies Against Bp230mentioning

confidence: 99%

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Role of BP230 autoantibodies in bullous pemphigoid

Shih

Wang

Yuan

et al. 2020

The Journal of Dermatology

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Bullous pemphigoid (BP) is an autoimmune disease associated with subepidermal blistering due to autoantibodies directed against BP180 and BP230. BP180 is currently considered as the major pathogenic autoantigen. However, previous clinical findings suggested that anti‐BP230 autoantibodies alone can cause skin lesions in animal models and many BP patients. The characteristics of BP230 and the pathogenic roles of anti‐BP230 antibodies have been proposed. First, at the molecular level, BP230 mediates the attachment of keratin intermediate filaments to the hemidesmosomal plaque and interacts with other constituents of hemidesmosomes. Second, the presence of BP230 autoantibodies may correlate with specific clinical features of BP. The immunoglobulin (Ig)G autoantibodies from BP patients react mainly against the C‐terminus of BP230, while the IgE autoantibodies are still inconclusive. Third, in vivo, autoantibodies against BP230 involved in the disease may not only induce the inflammatory response but also impair the structural stability of hemidesmosomes. This article reviews recently published work about the role of BP230 and its antibodies, including IgG and IgE, aiming to find clues of its clinical association and lay the foundation for the research on the pathogenicity of antibodies against BP230.

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Section: In Vivo Studies Of Autoantibodies Against Bp230mentioning

confidence: 99%

“…Recently, Haeberle et al. and Muramatsu et al. also successfully illuminated the pathogenic function of anti‐BP230 IgG autoantibodies.…”

Section: In Vivo Studies Of Autoantibodies Against Bp230mentioning

confidence: 99%

Role of BP230 autoantibodies in bullous pemphigoid

Shih

Wang

Yuan

et al. 2020

The Journal of Dermatology

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“…2,5 The interval between start of ICIs and BP onset was highly variable with a median of 6 months, as in our cases. 7 Hence, Tregs blockade may result in both autoreactive cellular and humoral response to the same antigenic targets of the epidermal and epithelial BMZ. 5 Immune checkpoint inhibitor therapy with anti-programmed death-1/ programmed death-ligand 1 results in a breakdown of tolerance, reduces activity of regulatory T cells (Tregs) and activates B cells and autoreactive T cells.…”

Section: Mucous Membrane Pemphigoid and Lichenoid Reactions After Immmentioning

confidence: 99%

Secukinumab for patients with plaque psoriasis affected by multiple sclerosis: a mini‐review with a representative case report

Venturini

Zanca

Venturuzzo

et al. 2019

Acad Dermatol Venereol

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remain high on the differential diagnosis. 2,8 Notably, peristomal skin complications are reported as high as 67%, and almost all patients with an ostomy experience some degree of irritant dermatitis. 2,9 Applying proper wound care principles to address devitalized tissue, infection and moisture imbalance are vital in the treatment of these other conditions. 10 We believe our patients' symptoms initially developed as an irritant dermatitis but were further exacerbated by poor wound healing and chronic irritation. If the clinical suspicion for PPG is low, we encourage an initial trial of aggressive wound care. After initiating proper wound care, clinical improvement without the use of immunosuppressants should raise suspicion for other common aetiologies of peristomal ulceration.

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“…Bullous pemphigoid (BP) is an organ‐specific autoimmune disease of the skin, characterized and caused by autoantibodies targeting BP180 and/or BP230 . In the ‘classical’ and name‐giving variant, BP patients present with blisters on inflamed skin.…”

mentioning

confidence: 99%

“…Based on these findings, and on experimental data, inflammation and blistering in BP has been thought to be mediated by BP180 autoantibodies only. However, the pathogenicity of anti‐BP230 autoantibodies has recently been well documented …”

mentioning

confidence: 99%