Regulatory <scp>B</scp> cells induced by ultraviolet <scp>B</scp> through toll‐like receptor 4 signalling contribute to the suppression of contact hypersensitivity responses in mice

Liu, Xiaoming; Huang, Haiyan; Gao, Hongbin; Wu, Xia; Zhang, Wei; Yu, Bo; Dou, Xia

doi:10.1111/cod.12913

Cited by 13 publications

(11 citation statements)

References 48 publications

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“…In a murine model of collagen-induced arthritis, B cells secreted IL-10 in the presence of BAFF and these cells suppressed CD4 + CD25 -T-cell proliferation leading to the inhibition of arthritis development. 102 Altogether these studies support the idea that there are multiple ways in which IL-10 production by B cells is induced. 97 There are other mediators that have been shown to induce IL-10 secretion by B cells like alteration in the gut commensal microbiota with antibiotics 98 ; antigen coupled to the B subunit of cholera toxin (CTB), 99 Vitamin D3 (VitD3), 100 and Retinoic Acid in combination with TLR-9 in healthy controls, but not in patients with MS, whom B cells have per se a reduced capacity to secrete IL-10.…”

Section: The Immunomodulatory Function Of Il-10 Produced By B Cellssupporting

confidence: 53%

“…95 BAFF has been shown to induce the proliferation and differentiation of B cells with an antiinflammatory function. 101 Another example is ultraviolet B (UVB) irradiation, which was known to suppress oxazolone-induced CHS in mice via an immune mechanism 102 and has recently been shown to increase numbers of IL-10-expressing B cells, which inhibit T-cell proliferation in CHS. 96 In human, IL-6 and IL-10 secretion by B cells increased after stimulation with BAFF; however, BAFF stimulation alone did not promote B cell-mediated IL-10 secretion.…”

Section: The Immunomodulatory Function Of Il-10 Produced By B Cellsmentioning

confidence: 99%

“…97 There are other mediators that have been shown to induce IL-10 secretion by B cells like alteration in the gut commensal microbiota with antibiotics 98 ; antigen coupled to the B subunit of cholera toxin (CTB), 99 Vitamin D3 (VitD3), 100 and Retinoic Acid in combination with TLR-9 in healthy controls, but not in patients with MS, whom B cells have per se a reduced capacity to secrete IL-10. 101 Another example is ultraviolet B (UVB) irradiation, which was known to suppress oxazolone-induced CHS in mice via an immune mechanism 102 and has recently been shown to increase numbers of IL-10-expressing B cells, which inhibit T-cell proliferation in CHS. 102 Altogether these studies support the idea that there are multiple ways in which IL-10 production by B cells is induced.…”

Section: The Immunomodulatory Function Of Il-10 Produced By B Cellsmentioning

confidence: 99%

“…101 Another example is ultraviolet B (UVB) irradiation, which was known to suppress oxazolone-induced CHS in mice via an immune mechanism 102 and has recently been shown to increase numbers of IL-10-expressing B cells, which inhibit T-cell proliferation in CHS. 102 Altogether these studies support the idea that there are multiple ways in which IL-10 production by B cells is induced.…”

Section: The Immunomodulatory Function Of Il-10 Produced By B Cellsmentioning

confidence: 99%

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Regulatory B cells: Development, phenotypes, functions, and role in transplantation

Alhabbab

Nova‐Lamperti

Aravena

et al. 2019

Immunological Reviews

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The interest in regulatory B cells (Bregs) began in the 1970s with the evidence that B cells could downregulate the immune system by the production of “inhibitory” antibodies. Subsequently, a series of results from different studies have emphasized that B cells have antibody‐independent immunoregulatory functions. Since then, different subsets of B cells with regulatory functions and their development and mechanisms of action have been identified both in human and in animal models of inflammation, transplantation, and autoimmunity. The present review outlines the suggested pathways by which Bregs develop, describes the different subsets of Bregs with their phenotypes and function as well as their role in transplantation, highlighting the differences between human and animal studies throughout.

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Section: The Immunomodulatory Function Of Il-10 Produced By B Cellssupporting

confidence: 53%

Section: The Immunomodulatory Function Of Il-10 Produced By B Cellsmentioning

confidence: 99%

Section: The Immunomodulatory Function Of Il-10 Produced By B Cellsmentioning

confidence: 99%

Section: The Immunomodulatory Function Of Il-10 Produced By B Cellsmentioning

confidence: 99%

See 2 more Smart Citations

Regulatory B cells: Development, phenotypes, functions, and role in transplantation

Alhabbab

Nova‐Lamperti

Aravena

et al. 2019

Immunological Reviews

View full text Add to dashboard Cite

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“…UV-R exposure also leads to infiltration of macrophages and neutrophils ( 41 – 43 ), induces emigration of Langerhans cells (LC) from the skin into the draining lymph nodes ( 44 – 46 ) and affects mast cells. Furthermore, regulatory T cells (Tregs) and B cells (Bregs) are recruited and activated ( 47 , 48 ). All these cells and UV-induced events are known to be involved in immune suppression ( 49 ) (Figure 1 ).…”

Section: Introductionmentioning

confidence: 99%

A Perspective on the Interplay of Ultraviolet-Radiation, Skin Microbiome and Skin Resident Memory TCRαβ+ Cells

et al. 2018

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The human skin is known to be inhabited by diverse microbes, including bacteria, fungi, viruses, archaea, and mites. This microbiome exerts a protective role against infections by promoting immune development and inhibiting pathogenic microbes to colonize skin. One of the factors having an intense effect on the skin and its resident microbes is ultraviolet-radiation (UV-R). UV-R can promote or inhibit the growth of microbes on the skin and modulate the immune system which can be either favorable or harmful. Among potential UV-R targets, skin resident memory T cells (TRM) stand as well positioned immune cells at the forefront within the skin. Both CD4+ or CD8+ αβ TRM cells residing permanently in peripheral tissues have been shown to play prominent roles in providing accelerated and long-lived specific immunity, tissue homeostasis, wound repair. Nevertheless, their response upon UV-R exposure or signals from microbiome are poorly understood compared to resident TCRγδ cells. Skin TRM survive for long periods of time and are exposed to innumerable antigens during lifetime. The interplay of TRM with skin residing microbes may be crucial in pathophysiology of various diseases including psoriasis, atopic dermatitis and polymorphic light eruption. In this article, we share our perspective about how UV-R may directly shape the persistence, phenotype, specificity, and function of skin TRM; and moreover, whether UV-R alters barrier function, leading to microbial-specific skin TRM, disrupting the healthy balance between skin microbiome and skin immune cells, and resulting in chronic inflammation and diseased skin.

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Phenotypes, roles, and modulation of regulatory lymphocytes in periodontitis and its associated systemic diseases

Zou

Zhou

Huang

et al. 2021

Journal of Leukocyte Biology

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Periodontitis is a common chronic inflammatory disease that can result in tooth loss and poses a risk to systemic health. Lymphocytes play important roles in periodontitis through multiple mechanisms. Regulatory lymphocytes including regulatory B cells (Bregs) and T cells (Tregs) are the main immunosuppressive cells that maintain immune homeostasis, and are critical to our understanding of the pathogenesis of periodontitis and the development of effective treatments. In this review, we discuss the phenotypes, roles, and modulating strategies of regulatory lymphocytes including Bregs and Tregs in periodontitis and frequently cooccurring inflammatory diseases such as rheumatoid arthritis, Alzheimer disease, diabetes mellitus, and stroke. The current evidence suggests that restoring immune balance through therapeutic targeting of regulatory lymphocytes is a promising strategy for the treatment of periodontitis and other systemic inflammatory diseases.

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Regulatory B cells induced by ultraviolet B through toll‐like receptor 4 signalling contribute to the suppression of contact hypersensitivity responses in mice

Abstract: Our data identified regulatory B cells as regulators of UVB-induced immunosuppression in CHS, and suggest the importance of the UVB-TLR4 axis in the generation of regulatory B cells.

Cited by 13 publications

References 48 publications

Regulatory B cells: Development, phenotypes, functions, and role in transplantation

Regulatory B cells: Development, phenotypes, functions, and role in transplantation

A Perspective on the Interplay of Ultraviolet-Radiation, Skin Microbiome and Skin Resident Memory TCRαβ+ Cells

Phenotypes, roles, and modulation of regulatory lymphocytes in periodontitis and its associated systemic diseases

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