Regulatory role of extracellular Na + and Ca 2+ ions in nerve growth factor induced histamine secretion from rat mast cells

Abstract

Our results suggest that the activity of Na+/Ca2+ and/or Na+/H+ exchange mechanisms could be of particular importance in the secretory process of mast cells induced by NGF.

Pruritus, pain, and small nerve fiber function in keloids: A controlled study

“…14 NGF induces histamine release from mast cells. 15,16 At the same time, mast cells are a source of NGF. 17 Thus, there may be a vicious cycle between mast cells and NGF to maintain histamine levels within a keloid, leading to chronic stimulation of nociceptors and pruriceptors of primary afferent nerve fibers, with generation of itch and pain sensations.…”

Ameliorative Potential of Pralidoxime in Tibial and Sural Nerve Transection-Induced Neuropathic Pain in Rats

“…36,37) Na ϩ /Ca 2ϩ exchanger, a bi-directional ion transporter is an important regulator of intracellular calcium levels. 38) In peripheral nerve injury, a key role of primary afferent inputs (sensitization of primary afferents) in the pathogenesis of neuropathic pain has been strongly suggested by several pharmacological studies. The nerve injury is associated with altered expression of different ion channels in peripheral myelinated mammalian axons and dorsal root ganglia.…”

Signaling pathway in nerve growth factor induced histamine release from rat mast cells

“…The secretion of histamine is totally dependent on the presence of extracellular Ca 2+ ions and on the addition of phosphatidylserine [39,40,41]. However, the biochemical pathway that leads to mast cell degranulation after NGF activation has not been defi ned yet.…”