Ameliorative Potential of Pralidoxime in Tibial and Sural Nerve Transection-Induced Neuropathic Pain in Rats

Kaur, Gurinder; Jaggi, Amteshwar Singh; Singh, Nirmal

doi:10.1248/bpb.33.1331

Cited by 6 publications

(5 citation statements)

References 43 publications

(49 reference statements)

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“…These behavioral alterations are constantly present and last over 2–3 weeks, but their time course varying upon the model and species [32]. In the present study Tibial and sural nerve transection-induced alterations in the nociceptive threshold, are consistent with the earlier reports [21,31]. Additionally TST also led to functional deficit in experimental animals.…”

Section: Discussionsupporting

confidence: 92%

“…Several studies demonstrated that various transaction, ligation, and crushing of sciatic nerve and its branches induces an ipsilateral mechanical, cold, heat hyperalgesia and allodynia thereby indicating the induction of peripheral neuropathic pain [3,31]. These behavioral alterations are constantly present and last over 2–3 weeks, but their time course varying upon the model and species [32].…”

Section: Discussionmentioning

confidence: 99%

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Attenuating effect of standardized fruit extract of punica granatum L in rat model of tibial and sural nerve transection induced neuropathic pain

Jain

Pareek

Bhardwaj

et al. 2013

BMC Complement Altern Med

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BackgroundInjury to a nerve is the most common reason of acquired peripheral neuropathy. Therefore, searching for effective substance to recover of nerve after injury is need of present era. The current study investigates the protective potential of Standardized Fruit Extract of Punica granatum L (PFE) [Ellagic acid (41.6%), Punicalagins (10%), Granatin (5.1%)] in Tibial & Sural Nerve Transection (TST) induced neuropathic pain in rats.MethodsTST was performed by sectioning tibial and sural nerve portions of the sciatic nerve and leaving the common peroneal nerve intact. Acetone drop, pin-prick, hot plate, paint brush & Walking Track tests were performed to assess cold allodynia; mechanical heat, hyperalgesia and dynamic mechanical allodynia & tibial functional index respectively. The levels of TNF-α, TBARS, GSH and Nitrite were measured in the sciatic nerve as an index of inflammation & oxidative stress.ResultsTST led to significant development of cold allodynia; mechanical and heat hyperalgesia; dynamic mechanical allodynia; functional deficit in walking along with rise in the levels of TBARS, TNF-α, GSH and Nitrite. Administrations of PFE (100 & 300 mg/kg oral), significantly attenuate TST induced behavioral & biochemical changes. Pretreatments of BADGE (120 mg/kg IP) a PPAR-γ antagonist and nitric oxide precursor L-arginine (100 mg/kg IP) abolished the protective effect of PFE. Whereas, pretreatment of L-NAME (5 mg/kg IP) a NOS inhibitor significantly potentiated PFE’s protective effect of PFE.ConclusionPFE shown to have attenuating effect in TST induced neuropathic pain which may be attributed to potential PPAR-gamma agonistic activity, nitric oxide inhibitory, anti-inflammatory and anti oxidative actions.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Attenuating effect of standardized fruit extract of punica granatum L in rat model of tibial and sural nerve transection induced neuropathic pain

Jain

Pareek

Bhardwaj

et al. 2013

BMC Complement Altern Med

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“…Central sensitization of neurons is a result of the motor as well as sensory fibers thus causes decrease in thermal withdrawal latency and increase in flicking response. Various transection, ligation and crushing of sciatic nerve and its branches induces ipsilateral cold, heat hyperalgesia and allodynia thereby indicating the induction of peripheral neuropathic pain [38,39]. These behavioral alterations are constantly present and last over 2-3 weeks, but their time course varying upon the model and species [40].…”

Section: Discussionmentioning

confidence: 99%

Alpha lipoic acid attenuated neuropathic pain induced by chronic constriction Injury of sciatic nerve in rats

Prasad

Prathapagiri

2021

Clin Phytosci

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Background Chronic neuropathic pain syndrome is associated with impaired quality of life and is poorly manageable. Alpha lipoic acid (ALA) is a powerful antioxidant and showed its effectiveness on diabetic neuropathy and other acute peripheral nerve injuries but it was not evaluated in the chronic neuropathic pain, chronic constriction injury (CCI) in rat model by using duloxetine (DLX) as standard. Methodology The main objective of the study was to expedite ALA effect on chronic peripheral neuropathy induced by CCI of sciatic nerve in rats. In this study, male Wister rats were randomly divided into six groups (n = 8) including, normal saline, sham operated, surgery control, DLX 30mg/kg treated, ALA treated 25mg/kg, and ALA+DLX. The CCI of sciatic nerve was conducted on all animals except normal saline group and studied for 21 days (i.e. 14 days treatment period & 7 days treatment free period) by using different behavioral, biochemical and, histopathology studies. Results ALA showed minor but significant decrease of thermal hyperalgesia, cold allodynia, malondialdehyde (MDA), total protein, lipid peroxidation, and nitric oxide levels and significant increase of motor coordination, glutathione level and decreased axonal degeneration significantly. These effects sustained even during treatment free period. ALA enhanced the effect of DLX when given in combination by showing sustained effect. In conclusion, ALA acted as potent antioxidant may be this activity is responsible for the potent neuroprotective effect. Conclusion Hence, ALA attenuated the nueroinflammation mediated by chronic peripheral neuropathy. Further studies are warranted with ALA to develop as a clinically relevant therapeutic agent for the treatment of neuropathic pain.

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“…The common peroneal nerve was not affected since it was kept intact. In two layers, the layers of muscle and skin were sealed off shown in Figure 4 (Kaur et al, 2010).…”

Section: Transsection Of the Tibial And Sural Nervesmentioning

confidence: 99%

Neuropathy; its profile and experimental nerve injury neuropathic pain models: A Review

Kumar

2023

Preprint

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Neuropathy is a terrible disorder that has a wide range of aetiologies. Drug-Induced Neuropathy, which happens whenever a chemical agent damages the peripheral nerve system, has been linked here to iatrogenic creation of some drugs. It is potentially permanent and causes sensory impairments and paresthesia that typically affects the hands, feet, and stockings; motor participation is uncommon. It might appear suddenly or over time, and the long-term outlook varies. The wide range of chronic pain conditions experienced by people has been some of the main obstacles to developing new, more effective medications for the treatment of neuropathic pain. Animal models can be used to examine various neuropathic pain aetiologies and symptoms. Several models investigate the peripheral processes of neuropathic pain, whereas some even investigate the central mechanisms. such as drug induce models like vincristine, cisplatin, bortezomib, or thalidomide, etc., and surgical models like sciatic nerve chronic constriction injury (CCI), sciatic nerve ligation through spinal nerve ligation (SNL), sciatic nerve damage caused by a laser, SNI (spared nerve injury), etc. The more popular animal models relying on peripheral nerve ligatures are explained. In contrast to chronic sciatic nerve contraction, which results in behavioral symptoms of less reliable stressful neuropathies, (SNI) spared nerve injury generates behavioral irregularities which are more feasible over a longer period. This review summarizes the latest methods models as well as clinical ideas concerning this mechanism. Every strongest current information on neuropathy is discussed, along with several popular laboratory models for causing neuropathy.

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Ameliorative Potential of Pralidoxime in Tibial and Sural Nerve Transection-Induced Neuropathic Pain in Rats

Cited by 6 publications

References 43 publications

Attenuating effect of standardized fruit extract of punica granatum L in rat model of tibial and sural nerve transection induced neuropathic pain

Attenuating effect of standardized fruit extract of punica granatum L in rat model of tibial and sural nerve transection induced neuropathic pain

Alpha lipoic acid attenuated neuropathic pain induced by chronic constriction Injury of sciatic nerve in rats

Neuropathy; its profile and experimental nerve injury neuropathic pain models: A Review

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