Regulatory parameters of self-healing alginate hydrogel networks prepared via mussel-inspired dynamic chemistry

Alegre‐Requena, Juan V.; Häring, Marleen; Herrera, Raquel P.; Díaz, David Díaz

doi:10.1039/c6nj02367c

Cited by 33 publications

(22 citation statements)

References 57 publications

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“…The wide range of dopamine grafting is achieved by altering the molar ratios of alginate to dopamine. The UV–visible absorption spectroscopy at 280 nm of the alginate–dopamine polymer revealed a dopamine content of 26%, which is close to the dopamine content in Mfp‐3, and also is within the range of dopamine content reported in other dopamine conjugated alginate polymers …”

Section: Resultssupporting

confidence: 79%

“…The dopamine content in mussel foot proteins (Mfps) varies from 10% to 15% in Mfp‐1, 2% to 4% in Mfp‐2, 25% in Mfp‐3, 5% in Mfp‐4, and 30% in Mfp‐5, whereas Mfp‐3 and Mfp‐5 are the proteins that contact the surface and help mussels adhere to wet surfaces . Some research groups reported that the dopamine contents incorporated into alginate ranged from 10% to 42% . The wide range of dopamine grafting is achieved by altering the molar ratios of alginate to dopamine.…”

Section: Resultsmentioning

confidence: 99%

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Biodegradable Nanoparticles Enhanced Adhesiveness of Mussel‐Like Hydrogels at Tissue Interface

Pandey

Hakamivala

et al. 2017

Adv Healthcare Materials

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Popular bioadhesives, such as fibrin, cyanoacrylate, and albumin-glutaraldehyde based materials, have been applied for clinical applications in wound healing, drug delivery, and bone and soft tissue engineering; however, their performances are limited by weak adhesion strength and rapid degradation. In this study a mussel-inspired, nanocomposite-based, biodegradable tissue adhesive is developed by blending poly(lactic-co-glycolic acid) (PLGA) or N-hydroxysuccinimide modified PLGA nanoparticles (PLGA-NHS) with mussel-inspired alginate-dopamine polymer (Alg-Dopa). Adhesive strength measurement of the nanocomposites on porcine skin-muscle constructs reveals that the incorporation of nanoparticles in Alg-Dopa significantly enhances the tissue adhesive strength compared to the mussel-inspired adhesive alone. The nanocomposite formed by PLGA-NHS nanoparticles shows higher lap shear strength of 33 ± 3 kPa, compared to that of Alg-Dopa hydrogel alone (14 ± 2 kPa). In addition, these nanocomposites are degradable and cytocompatible in vitro, and elicit in vivo minimal inflammatory responses in a rat model, suggesting clinical potential of these nanocomposites as bioadhesives.

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Section: Resultssupporting

confidence: 79%

Section: Resultsmentioning

confidence: 99%

Biodegradable Nanoparticles Enhanced Adhesiveness of Mussel‐Like Hydrogels at Tissue Interface

Pandey

Hakamivala

et al. 2017

Adv Healthcare Materials

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“…[86][87][88][89][90][91] Mussel-inspired biomimetic polymers have been mainly prepared from polyesters, [88,89] polyamides, [92] polyacrylates, [93][94][95][96] polyethylene glycols, [16,[97][98][99] polyoxetanes, [87,91] polystyrenes [86,100] polypeptides, [101][102][103] and polysaccharides. [104,105] Ther esults defined ar ange for the optimal catechol content close to that observed in mfps,b ut with differences depending on the nature of the material used. However, despite this growing number of synthetic polymers mimicking adhesive proteins of mussels,the number of detailed and systematic studies aimed at elucidating this issue is rather limited.…”

Section: Catechol Content and Molecular Weightmentioning

confidence: 99%

The Chemistry behind Catechol‐Based Adhesion

et al. 2018

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The adhesion of some marine organisms to almost any kind of surface in wet conditions has aroused increasing interest in recent decades. Numerous fundamental studies have been performed to understand the scientific basis of this behaviour, with catechols having been found to play a key role. Several novel bio-inspired adhesives and coatings with value-added performances have been developed by taking advantage of the knowledge gained from these studies. To date there has been no detailed overview focusing exclusively on the complex mode of action of these materials. The aim of this Review is to present recent investigations that elucidate the origin of the strong and versatile adsorption capacities of the catechol moiety and the effects of extrinsic factors that play important roles in the overall adhesion process, such as pH value, solvent, and the presence of metal ions. The aim is to detail the chemistry behind the astonishing properties of natural and synthetic catechol-based adhesive materials.

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“…[ 86 , 87 , 88 , 89 , 90 , 91 ] Mussel-inspired biomimetic polymers have been mainly prepared from polyesters, [88,89] polyamides, [ 92 ] polyacrylates, [ 93 , 94 , 95 , 96 ] polyethylene glycols, [16, 97 , 98 , 99 ] polyoxetanes, [87,91] polystyrenes [86,100 ] polypeptides [ 101 , 102 , 103 ] and polysaccharides. [104,105] The results defined a range of optimal catechol content close to that observed in mfps but with differences depending on the nature of the material used. However, despite this growing number of synthetic polymers mimicking mussel adhesive proteins, the number of detailed and systematic studies aimed at elucidating this issue is rather limited.…”

Section: Accepted Manuscriptmentioning

confidence: 70%

Die chemischen Grundlagen der Adhäsion von Catechol

et al. 2018

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The wet adhesion of some marine organisms to almost any kind of surface has aroused increasing interest over recent decades. Numerous fundamental studies have been performed to understand the scientific basis of this behaviour, where catechols have been found to play a key role. Several novel bioinspired adhesives and coatings with value-added performances have been developed by taking advantage of the knowledge gained from these studies. Excellent reviews of this issue have been published due to the large amount of interest and generated literature. Nevertheless, no detailed compilation exclusively focused on the complex inner workings of these materials exists. Thus, the aim of this work is to review recent investigations that elucidate the origin of the strong and versatile adsorption capacities of the catechol moiety and the effects of extrinsic factors playing important roles in the overall adhesion process, such as pH, solvent and the presence of metal ions. In other words, it is our aim to review in detail the chemistry behind the astonishing properties of natural and synthetic catecholbased adhesive materials.

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Regulatory parameters of self-healing alginate hydrogel networks prepared via mussel-inspired dynamic chemistry

Abstract: Key parameters that influence the self-healing and water retention properties of hydrogels made of alginate–dopamine conjugates have been revealed.

Cited by 33 publications

References 57 publications

Biodegradable Nanoparticles Enhanced Adhesiveness of Mussel‐Like Hydrogels at Tissue Interface

Biodegradable Nanoparticles Enhanced Adhesiveness of Mussel‐Like Hydrogels at Tissue Interface

The Chemistry behind Catechol‐Based Adhesion

Die chemischen Grundlagen der Adhäsion von Catechol

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