Regulatory mechanisms of microRNAs in endocrine disorders and their therapeutic potential

Ledesma-Pacheco, S. Janin; Urióstegui-Pena, Andrea G.; Rodriguez-Jacinto, Estefania; Gomez-Hernandez, Elizabeth; Estrada-Meza, Carolina; Banerjee, Antara; Pathak, Surajit; Ruiz‐Manriquez, Luis M.; Duttaroy, Asim K.; Paul, Sujay

doi:10.3389/fgene.2023.1137017

Cited by 10 publications

(10 citation statements)

References 104 publications

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“…Small non-coding RNA molecules called microRNAs (miRNAs) are essential for post-transcriptional gene control [28]. They bind to the 3 untranslated region of target messenger RNAs, leading to translational inhibition or messenger RNA degradation.…”

Section: Nafld Pathogenesismentioning

confidence: 99%

Innate Immune System in the Pathogenesis of Non-Alcoholic Fatty Liver Disease

Won

Yoon

et al. 2023

Nutrients

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Non-alcoholic fatty liver disease (NAFLD) is a prevalent condition characterized by lipid accumulation in hepatocytes with low alcohol consumption. The development of sterile inflammation, which occurs in response to a range of cellular stressors or injuries, has been identified as a major contributor to the pathogenesis of NAFLD. Recent studies of the pathogenesis of NAFLD reported the newly developed roles of damage-associated molecular patterns (DAMPs). These molecules activate pattern recognition receptors (PRRs), which are placed in the infiltrated neutrophils, dendritic cells, monocytes, or Kupffer cells. DAMPs cause the activation of PRRs, which triggers a number of immunological responses, including the generation of cytokines that promote inflammation and the localization of immune cells to the site of the damage. This review provides a comprehensive overview of the impact of DAMPs and PRRs on the development of NAFLD.

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Section: Nafld Pathogenesismentioning

confidence: 99%

Innate Immune System in the Pathogenesis of Non-Alcoholic Fatty Liver Disease

Won

Yoon

et al. 2023

Nutrients

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“…Endocrine disorders are the fifth principal cause of mortality worldwide. In recent years, miRNA’s regulatory mechanism could be more effective in diagnostic and therapeutic tools for treating people who have various biological processes associated with endocrine disorders [ 25 ].…”

Section: Reviewmentioning

confidence: 99%

Effects of Endocrine Disrupting Chemicals (EDCs) on Skeletal System Development: A Review

Thotakura,

et al. 2023

Cureus

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Introduction: Endocrine-disrupting chemicals (EDCs) are exogenous substances that alter endocrine function and cause adverse effects on an organism. EDC interference with the endocrine system leads to chronic autoimmune disorders, abnormal osteogenesis, infertility, and reproductive, neurological, cardiovascular, and metabolic disorders. Among the adverse effects of EDCs are their impact on developing fetuses and neonates. EDCs like bisphenol A (BPA), pesticides, and lead interfere with or alter sex steroid hormone synthesis and metabolism, leading to developmental delay, infertility, and urogenital carcinoma in both sexes.Objective: This review article examines the most harmful EDC, BPA, which affects the skeletal system during the embryonic period. The literature investigates the effects of BPA on various systems in our body, but the mechanism behind skeletal system development during the embryonic period is still unknown.Materials and methods: In the present review, 25 articles were reviewed through multiple windows like PubMed, Scopus, and Web of Science. Many articles mention the effects of BPA on the skeletal system after birth and also examine reproductive system abnormalities, hereditary characteristics, excretory system malfunctions, and physical and mental illness in various mechanisms.Discussion: The impact of BPA on the skeletal system causes morphological and physiological changes in developing embryos. The general ideology regarding skeletal system development and its mechanism is as follows: the formation of bone (osteocytes) is reduced by the apoptosis of precursor bone cells (osteoblasts) by the effect of BPA.Conclusion: EDC exposure induces the apoptosis of bone cells and inhibits the formation of osteoblasts, and long-term exposure to these chemicals will also impact immune system development.

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“…Inversely, low miRNA levels are associated with higher mRNA concentration [ 29 ]. Nearly 60% of the human genome is regulated by miRNAs, suggesting that they are involved in almost all essential cellular functions [ 30 , 31 ]. Mounting evidence has demonstrated that miRNA expression is frequently altered in complex pathophysiologies, including cancer [ 32 , 33 , 34 ].…”

Section: Introductionmentioning

confidence: 99%

Exploring the Potential Role of Circulating microRNAs as Biomarkers for Predicting Clinical Response to Neoadjuvant Therapy in Breast Cancer

Ruiz-Manriquez,

Villarreal-Garza,

Benavides-Aguilar

et al. 2023

IJMS

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Breast cancer (BC) is a leading cause of cancer-related deaths among women worldwide. Neoadjuvant therapy (NAT) is increasingly being used to reduce tumor burden prior to surgical resection. However, current techniques for assessing tumor response have significant limitations. Additionally, drug resistance is commonly observed, raising a need to identify biomarkers that can predict treatment sensitivity and survival outcomes. Circulating microRNAs (miRNAs) are small non-coding RNAs that regulate gene expression and have been shown to play a significant role in cancer progression as tumor inducers or suppressors. The expression of circulating miRNAs has been found to be significantly altered in breast cancer patients. Moreover, recent studies have suggested that circulating miRNAs can serve as non-invasive biomarkers for predicting response to NAT. Therefore, this review provides a brief overview of recent studies that have demonstrated the potential of circulating miRNAs as biomarkers for predicting the clinical response to NAT in BC patients. The findings of this review will strengthen future research on developing miRNA-based biomarkers and their translation into medical practice, which could significantly improve the clinical management of BC patients undergoing NAT.

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Regulatory mechanisms of microRNAs in endocrine disorders and their therapeutic potential

Cited by 10 publications

References 104 publications

Innate Immune System in the Pathogenesis of Non-Alcoholic Fatty Liver Disease

Innate Immune System in the Pathogenesis of Non-Alcoholic Fatty Liver Disease

Effects of Endocrine Disrupting Chemicals (EDCs) on Skeletal System Development: A Review

Exploring the Potential Role of Circulating microRNAs as Biomarkers for Predicting Clinical Response to Neoadjuvant Therapy in Breast Cancer

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