Exploring the Potential Role of Circulating microRNAs as Biomarkers for Predicting Clinical Response to Neoadjuvant Therapy in Breast Cancer

Ruiz-Manriquez, Luis M.; Villarreal-Garza, Cynthia; Benavides-Aguilar, Javier A.; Torres-Copado, Andrea; Isidoro-Sánchez, José; Estrada-Meza, Carolina; Arvizu-Espinosa, María Goretti; Paul, Sujay; Cuevas-Diaz Duran, Raquel

doi:10.3390/ijms24129984

Cited by 7 publications

(6 citation statements)

References 144 publications

(171 reference statements)

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“…miR-155 was also shown to target PTEN, leading to its downregulation, and this contributes to increased PI3K/Akt signaling and oncogenic processes . Expression level of miR-155 was found to be closely related to the status of the ER and PGR . Furthermore, miR-155 has been reported to target STATs in certain contexts, affecting downstream signaling pathways involved in cell proliferation, survival, and immune response.…”

Section: Discussionmentioning

confidence: 99%

“… 57 Expression level of miR-155 was found to be closely related to the status of the ER and PGR. 58 Furthermore, miR-155 has been reported to target STATs in certain contexts, affecting downstream signaling pathways involved in cell proliferation, survival, and immune response. Dysregulation of miR-155-mediated STAT regulation may contribute to cancer progression and resistance to therapy.…”

Section: Discussionmentioning

confidence: 99%

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BRCA Mutations and MicroRNA Expression Patterns in the Peripheral Blood of Breast Cancer Patients

Alavanda,

Dirimtekin,

Mortoglou

et al. 2024

ACS Omega

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Breast cancer (BC) persists as the predominant malignancy globally, standing as the foremost cause of cancer-related mortality among women. Despite notable advancements in prevention and treatment, encompassing the incorporation of targeted immunotherapies, a continued imperative exists for the development of innovative methodologies. These methodologies would facilitate the identification of women at heightened risk, enhance the optimization of therapeutic approaches, and enable the vigilant monitoring of emergent treatment resistance. Circulating microRNAs (miRNAs), found either freely circulating in the bloodstream or encapsulated within extracellular vesicles, have exhibited substantial promise for diverse clinical applications. These applications range from diagnostic and prognostic assessments to predictive purposes. This study aimed to explore the potential associations between BRCA mutations and specific miRNAs (miR-21, miR-155, miR-126, and miR-200c) expression that are known to be dysregulated in BC patient samples. Our findings indicate a robust correlation between miRNA expression status and disease subtypes. We found a correlation between the expression status of miRNAs and distinct disease subtypes. Intriguingly, however, no significant associations were discerned between disease status, subtypes, or miRNA expression levels and the presence of BRCA mutations. To advance the validation of miRNAs as clinically relevant biomarkers, additional investigations within larger and meticulously selected patient cohorts are deemed imperative. These microRNA entities hold the potential to emerge as groundbreaking and readily accessible tools, poised for seamless integration into the landscape of clinical practice.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

BRCA Mutations and MicroRNA Expression Patterns in the Peripheral Blood of Breast Cancer Patients

Alavanda,

Dirimtekin,

Mortoglou

et al. 2024

ACS Omega

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“…Better patient outcomes will result from the early detection of circulating miRNA that can diagnose illness and/or chemotherapeutic responses. This would considerably simplify improved treatments ( 91 ).…”

Section: Mirna As New Diagnostic and Prognostic Markersmentioning

confidence: 99%

The role of miRNAs as biomarkers in breast cancer

Baylie,

Kasaw,

Getinet

et al. 2024

Front. Oncol.

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Breast cancer (BC) is the second most common cause of deaths reported in women worldwide, and therefore there is a need to identify BC patients at an early stage as timely diagnosis would help in effective management and appropriate monitoring of patients. This will allow for proper patient monitoring and effective care. However, the absence of a particular biomarker for BC early diagnosis and surveillance makes it difficult to accomplish these objectives. miRNAs have been identified as master regulators of the molecular pathways that are emphasized in various tumors and that lead to the advancement of malignancies. Small, non-coding RNA molecules known as miRNAs target particular mRNAs to control the expression of genes. miRNAs dysregulation has been linked to the start and development of a number of human malignancies, including BC, since there is compelling evidence that miRNAs can function as tumor suppressor genes or oncogenes. The current level of knowledge on the role of miRNAs in BC diagnosis, prognosis, and treatment is presented in this review. miRNAs can regulate the tumorigenesis of BC through targeting PI3K pathway and can be used as prognostic or diagnostic biomarkers for BC therapy. Some miRNAs, like miR-9, miR-10b, and miR-17-5p, are becoming known as biomarkers of BC for diagnosis, prognosis, and therapeutic outcome prediction. Other miRNAs, like miR-30c, miR-187, and miR-339-5p, play significant roles in the regulation of hallmark functions of BC, including invasion, metastasis, proliferation, resting death, apoptosis, and genomic instability. Other miRNAs, such as miR-155 and miR-210, are circulating in bodily fluids and are therefore of interest as novel, conveniently accessible, reasonably priced, non-invasive methods for the customized care of patients with BC.

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“…miRNAs are small, non-coding RNA molecules (20-24 nucleotides) that are involved in numerous biological processes [14,15]. These tiny molecules are highly conserved and act as regulators of gene expression through the attenuation or degradation of messenger RNA (mRNA) [16,17].…”

Section: Introductionmentioning

confidence: 99%

“…miRNAs are substantially involved in the pathogenesis of multiple chronic diseases, such as cancer [14,28,29], diabetes [30], endocrine disorders [17], and obesity [31], and could contribute to a better prognosis and management of those ailments [20].…”

Section: Introductionmentioning

confidence: 99%

The Regulatory Role of MicroRNAs in Obesity and Obesity-Derived Ailments

Benavides-Aguilar,

Torres-Copado,

Isidoro-Sánchez

et al. 2023

Genes

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Obesity is a condition that is characterized by the presence of excessive adipose tissue in the body. Obesity has become one of the main health concerns worldwide since it can lead to other chronic ailments, such as type 2 diabetes or fatty liver disease, and it could be an aggravating factor in infections. MicroRNAs (miRNAs) are small, non-coding RNA molecules that regulate gene expression and can play an important role in controlling crucial biological processes involved in the onset of obesity, such as lipogenesis, adipogenesis, lipid metabolism, or the regulation of cytokines and chemokines. Moreover, chemical compounds present in food or food packaging can alter miRNA expression and regulate the aforementioned biological mechanisms related to diabetes onset and progression. Furthermore, therapies, such as bariatric surgery and aerobic exercise training, can also influence the expression profile of miRNAs in obesity. Therefore, the present review provides insight into the current research on the role of miRNAs in obesity and obesity-derived ailments, intending to develop novel therapies to effectively manage these disorders.

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Exploring the Potential Role of Circulating microRNAs as Biomarkers for Predicting Clinical Response to Neoadjuvant Therapy in Breast Cancer

Cited by 7 publications

References 144 publications

BRCA Mutations and MicroRNA Expression Patterns in the Peripheral Blood of Breast Cancer Patients

BRCA Mutations and MicroRNA Expression Patterns in the Peripheral Blood of Breast Cancer Patients

The role of miRNAs as biomarkers in breast cancer

The Regulatory Role of MicroRNAs in Obesity and Obesity-Derived Ailments

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