Regulatory mechanism of mineral-balanced deep sea water on hypocholesterolemic effects in HepG2 hepatic cells

Lee, Kyu-Shik; Kwon, Yun‐Suk; Kim, Soyoung; Moon, Deok-Soo; Kim, Hyeon Ju; Nam, Kyung‐Soo

doi:10.1016/j.biopha.2016.12.046

Cited by 21 publications

(16 citation statements)

References 46 publications

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“…), there is a lack of evidence that DSW has biologically beneficial functions. The biological effects of DSW on obesity, hypertension, inflammation, atopic eczema/dermatitis syndrome and cancer have been reported in several studies (7,(9)(10)(11)(12). Moreover, dSW has been shown to exert suppressive effects on hyperlipidemia and atherosclerosis in animals fed a high cholesterol diet (13)(14)(15).…”

Section: Introductionmentioning

confidence: 93%

Anti‑platelet activity of mineral‑balanced deep sea water is�mediated via the regulation of Akt and ERK pathway crosstalk

2019

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Mineral-balanced deep sea water (MBdSW), an unlimited natural sea source, has been demonstrated to minimize the risk of developing cardiovascular diseases, such as obesity, hypertension, inflammation and hyperlipidemia. This study investigated the effects of MBdSW [magnesium (Mg):calcium (Ca) ratio, 3:1] on platelet activation. MBDSW significantly inhibited the collagen-and thrombin-induced platelet aggregation of human platelets. In collagen-induced platelets, MBdSW inhibited intracellular calcium mobilization, granule secretion [serotonin, adenosine triphosphate (ATP) and P-selectin expression] and thromboxane A 2 (TXA 2 ) production. Moreover, MBDSW markedly inhibited Akt and extracellular signal-regulated kinase (ERK) phosphorylation, but not that of c-Jun N-terminal kinase (JNK) and p38. Moreover, MBDSW phosphorylated inositol 1,4,5-triphosphate receptor (IP 3 R) and vasodilator-stimulated phosphoprotein (VASP), and it increased the cyclic adenosine monophosphate (cAMP) level in collagen-induced human platelets. Dipyridamole, a phosphodiesterase (PDE) inhibitor, significantly increased the cAMP level and regulated the Akt, ERK and VASP (Ser 157 ) levels in a manner similar to that of MBDSW. In addition, LY294002, an Akt inhibitor, inhibited the phosphorylation of ERK, and U0126, an ERK inhibitor, inhibited the phosphorylation of Akt. Taken together, the results of the present investigation suggest that the inhibitory effects of MBdSW on platelet aggregation may be associated with the cross-inhibition of Akt and ERK phosphorylation. These results strongly indicate that MBdSW may have preventive or therapeutic potential for platelet aggregation-mediated diseases, such as thrombosis, atherosclerosis and myocardial infarction.

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Section: Introductionmentioning

confidence: 93%

Anti‑platelet activity of mineral‑balanced deep sea water is�mediated via the regulation of Akt and ERK pathway crosstalk

2019

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“…The ability of DSW in reducing serum levels of ALT is shown in HFD fed mice [121]. Others showed that the DSW reduces the level of TC, downregulates the expression of HMGCR, upregulates AMPK phosphorylation, and decreases the synthesis of cholesterol in HepG2 cells, Meanwhile, it could also upregulate the expression of LDLR, PPAR-alpha, SREBP-1alpha and SREBP-2, and can lower the expression of the proprotein convertase subtilisin/kexin type 9 (PCSK9) [122]. The fact that DSW reduced the levels of TC and LDL-C whereas increased the level of HDL-C, decreased the expression of fatty acid synthase and SREBP-1c in the blood of rats fed with a HFD and enhanced the expression of LDLR, thus exerting a lipid lowering effect was also showed [123].…”

Section: Secondary Metabolites and Other Marine-derived Productsmentioning

confidence: 99%

Advances in the Study of Marine Products with Lipid-Lowering Properties

et al. 2020

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With twice the number of cancer’s deaths, cardiovascular diseases have become the leading cause of death worldwide. Atherosclerosis, in particular, is a progressive, chronic inflammatory cardiovascular disease caused by persistent damage to blood vessels due to elevated cholesterol levels and hyperlipidemia. This condition is characterized by an increase in serum cholesterol, triglycerides, and low-density lipoprotein, and a decrease in high-density lipoprotein. Although existing therapies with hypolipidemic effects can improve the living standards of patients with cardiovascular diseases, the drugs currently used in clinical practice have certain side effects, which insists on the need for the development of new types of drugs with lipid-lowering effects. Some marine-derived substances have proven hypolipidemic activities with fewer side effects and stand as a good alternative for drug development. Recently, there have been thousands of studies on substances with lipid-lowering properties of marine origin, and some are already implemented in clinical practice. Here, we summarize the active components of marine-derived products having a hypolipidemic effect. These active constituents according to their source are divided into algal, animal, plant and microbial and contribute to the development and utilization of marine medicinal products with hypolipidemic effects.

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“…Moreover, the location is adjacent to Taipei-Keelung metropolitan area, which makes the transportation more convenient [9]. Several advantages make Nan'ao waters one of the best candidates in Taiwan to develop DOW industry [10,11]. Together with the DOW can be applied to salmon aquaculture industry with its high economic values not only can it promote the extensive values of Marine Bioscience Park but also create huge benefits [9,10].…”

Section: Introductionmentioning

confidence: 99%

Strategic Review on Developing Salmon Aquaculture with Deep Ocean Water: A Case Study of Nan’ao Deep Ocean Water Park in Yilan County, Taiwan

Chen¹,

Chen²,

Chou³

2018

Fish Aquac J

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Currently the utilization of deep ocean water (DOW or deep sea water/DSW) is receiving much attention due to its high added value with large quantity, high productivity and potential for recycling energy. Deep ocean water possesses three main characteristics: low temperature, cleanliness and nutrient richness. In eastern Taiwan, the steep coastal landforms make it a great potential to develop deep ocean water industry. In order to promote DOW related industry, Yilan County government in eastern Taiwan has established DOW Park in Nan'ao Township. Through commercializing the DOW resources and introducing non-governmental investment from the private sectors, the DOW Park aims to promote regional development and upgrade the related industries. In the present study, we investigated the potential market demands, technical conditions and its biological natures of developing salmon aquaculture at Nan'ao DOW Park. It aims to take advantage of the characteristics of DOW to propose industrial strategies on salmon aquaculture with DOW and establish the developmental goals at different times. In general, three stages i.e. short, medium and long-term stages will be analyzed respectively. In the short-term stage, the objective of harvested salmon is to achieve 30,000 mt yr-1 for the domestic market demands in the common size of 1 kg-5 kg fish-1. In the medium and long-term stages, the objectives are focusing on the markets in Japan, China and Southeast Asian countries, aiming to achieve the salmon harvest with 300,000 mt-500,000 mt year-1. The domestic market of the DOW salmon industry is estimated to reach approximately US$ 330 million (NT$ 10 billion) of linking industrial cluster and global value chain. The study may also provide the government an innovative strategy and market orientation towards DOW industry guidance as well an investment consideration for enterprises having an interest in developing DOW related industry.

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Regulatory mechanism of mineral-balanced deep sea water on hypocholesterolemic effects in HepG2 hepatic cells

Cited by 21 publications

References 46 publications

Anti‑platelet activity of mineral‑balanced deep sea water is�mediated via the regulation of Akt and ERK pathway crosstalk

Anti‑platelet activity of mineral‑balanced deep sea water is�mediated via the regulation of Akt and ERK pathway crosstalk

Advances in the Study of Marine Products with Lipid-Lowering Properties

Strategic Review on Developing Salmon Aquaculture with Deep Ocean Water: A Case Study of Nan’ao Deep Ocean Water Park in Yilan County, Taiwan

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