2015
DOI: 10.1016/j.jneuroim.2015.03.008
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Regulatory function of CD4+CD25++ T cells in patients with myasthenia gravis is associated with phenotypic changes and STAT5 signaling: 1,25-Dihydroxyvitamin D3 modulates the suppressor activity

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Cited by 36 publications
(41 citation statements)
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“…We did observe an association between 25-vitD levels and the amount of CD4 + CD25 +high PD-1 + T cells at baseline, but this association was not sustained by oral vitamin D or placebo treatment. The TCR- stimulation induced PD1-uregulation in CD4 + T cells was more pronounced in CD than in HC, which is line with previous findings in patients with other chronic inflammatory diseases than CD [24, 30]. …”
Section: Discussionsupporting
confidence: 92%
“…We did observe an association between 25-vitD levels and the amount of CD4 + CD25 +high PD-1 + T cells at baseline, but this association was not sustained by oral vitamin D or placebo treatment. The TCR- stimulation induced PD1-uregulation in CD4 + T cells was more pronounced in CD than in HC, which is line with previous findings in patients with other chronic inflammatory diseases than CD [24, 30]. …”
Section: Discussionsupporting
confidence: 92%
“…CD4 + CD25 + FoxP3 + regulatory T cells have a key role in controlling autoimmunity and maintaining immunologic selftolerance [105]. Recent studies have reported functional defects of CD4 + CD25 + regulatory T cells from thymuses of MG patients and reduction in peripheral regulatory T cell population in untreated MG patients [106][107][108][109][110][111][112]. Impairment of suppressive activity of regulatory T cells and reduction in frequency of regulatory T cells in the spleen and peripheral blood were also demonstrated in EAMG rats [113,114].…”
Section: Mechanisms Of Specific Immunotherapymentioning
confidence: 99%
“…The transcription factor FoxP3 is selectively expressed in Tregs, which is the key modulators of Tregs activation and function (Marson et al, 2007). Tregs actively mediate self-tolerance and thus control autoimmunity by suppressing the activation, proliferation, and effector function such as a cytokine production of various immune cells (Sakaguchi et al, 2008; Alahgholi-Hajibehzad et al, 2015b). Conversely, Th17 cells play a crucial role in the initiation and maintenance of autoimmune tissue injury (Schaffert et al, 2015).…”
Section: Discussionmentioning
confidence: 99%