Regulatory Efficacy of Brown Seaweed <i>Lessonia nigrescens</i> Extract on the Gene Expression Profile and Intestinal Microflora in Type 2 Diabetic Mice

Zhao, Chao; Yang, Chengfeng; Chen, Mingjun; Lv, Xu-Cong; Liu, Bin; Yi, Lunzhao; Cornara, Laura; Wei, Ming-Chi; Yang, Yu-Chiao; Tundis, Rosa; Xiao, Jianbo

doi:10.1002/mnfr.201700730

Cited by 55 publications

(33 citation statements)

References 30 publications

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“…Furthermore, it also increased the abundances of Lachnospiraceae NK4A136 group and Alisties , affecting the release of intestinal hormones for regulating insulin release. The antidiabetic activity of brown seaweed Lessonia nigrescens ethanolic extract (LNE), including phenolics and flavonoids, was investigated in type 2 diabetic mice fed with a high‐sucrose/high‐fat diet by (Zhao et al., 2018). They showed that the intake of LNE increased the growth of Barnesiella , Helicobacter , and Turicibacter , which were able to stimulate the host's antidiabetic effect, accompanied with the modification in the gene and protein expression of hepatic phosphatidylinositol 3‐kinase and c‐Jun N‐terminal kinase.…”

Section: Dietary Polyphenols and The Gut Microbiome For Diabetesmentioning

confidence: 99%

Dietary polyphenols as antidiabetic agents: Advances and opportunities

et al. 2020

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Dietary polyphenols have been widely investigated as antidiabetic agents in cell, animals, human study, and clinical trial. The number of publication (Indexed by Web of Science) on "polyphenols and diabetes" significantly increased since 2010. This review highlights the advances and opportunities of dietary polyphenols as antidiabetic agents.Dietary polyphenols prevent and manage Type 2 diabetes mellitus via the insulindependent approaches, for instance, protection of pancreatic islet -cell, reduction of -cell apoptosis, promotion of -cell proliferation, attenuation of oxidative stress, activation of insulin signaling, and stimulation of pancreas to secrete insulin, as well as the This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. c ○ 2020 The Authors. Food Frontiers published

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Section: Dietary Polyphenols and The Gut Microbiome For Diabetesmentioning

confidence: 99%

Dietary polyphenols as antidiabetic agents: Advances and opportunities

et al. 2020

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“…The in vivo anti-diabetic efficacy of seaweed has been shown in many animal studies (Gabbia et al 2017;Roy et al 2011;Song et al 2018;Zhao et al 2018). In human clinical trials, daily supplementation with Undaria pinnatifida and Sacchariza polyschides (as Gigantea bulbosa) balances blood glucose levels, decreases serum triglyceride concentrations, and increases high-density lipoprotein cholesterol in subjects with type 2 diabetes (Kim et al 2008).…”

Section: Type 2 Diabetesmentioning

confidence: 99%

Seaweeds as nutraceuticals for health and nutrition

2019

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Throughout human history, seaweeds have been used as food, folk remedies, dyes, and mineral-rich fertilisers. Seaweeds as nutraceuticals or functional foods with dietary benefits beyond their fundamental macronutrient content, are now a major research and industrial development concept. The occurrence of dietary and lifestyle-related diseases, notably type 2 diabetes, obesity, cancer, and metabolic syndrome has become a health epidemic in developed countries. Global epidemiological studies have shown that countries where seaweed is consumed on a regular basis have significantly fewer instances of obesity and dietary-related disease. This review outlines recent developments in seaweed applications for human health from an epidemiological perspective and as a functional food ingredient.

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“…In the same study, these investigators also showed green macroalgae significantly increased the relative abundance of Akkermansia and decreased the proportion of Alistipes and Turicibacter. Zhao et al (2018) reported the anti-diabetic activity of Lessonia nigrescens ethanolic extract. Specifically, Lessonia nigrescens ethanolic extract could selectively enrich the amounts of beneficial bacteria, Barnesiella, as well as reduce the abundances of Clostridium and Alistipes.…”

Section: Phytochemicalsmentioning

confidence: 99%

The interaction between dietary marine components and intestinal flora

Lin

Xue

Zhang

et al. 2020

Mar Life Sci Technol

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The intestine is the natural habitat for a large and dynamic bacterial community, which perform vital metabolic and immune functions that significantly effect the nutritional and health status of the host. The major physiological functions of intestinal flora include metabolic activities that lead to important trophic effects on immune structure and function as well as protection of the colonized host against invasion by transient microbes. The intestinal flora is both a target for nutritional intervention and a factor influencing the biological activity of food compounds acquired orally. Marine environments, as a source of diverse organic compounds, can supply us with a number of beneficial and health-promoting ingredients. This review focuses on the physiological functions of intestinal flora and reciprocal interactions between intestinal flora and dietary marine components including polysaccharides, lipids, protein, taurine, carotenoids, minerals, and polyphenols. This review can serve as a valuable reference regarding the consumption of seafood and marine nutraceuticals.

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Regulatory Efficacy of Brown Seaweed Lessonia nigrescens Extract on the Gene Expression Profile and Intestinal Microflora in Type 2 Diabetic Mice

Abstract: The above findings suggest that LNE could be considered as a functional food for reducing blood glucose and regulating intestinal microflora.

Cited by 55 publications

References 30 publications

Dietary polyphenols as antidiabetic agents: Advances and opportunities

Dietary polyphenols as antidiabetic agents: Advances and opportunities

Seaweeds as nutraceuticals for health and nutrition

The interaction between dietary marine components and intestinal flora

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