Regulatory effects of miRNA-126 on Th cell differentiation and cytokine expression in allergic rhinitis

JIA, HONG-LIN; Zhang, Ru; Liang, Xiaoying; Jiang, Xiaofang; Bu, Qian

doi:10.1016/j.cellsig.2022.110435

Cited by 5 publications

(3 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The miRNA and lncRNA almost participate in the whole process of AR pathogenesis and persistence, including the injury reaction of nasal epithelial cells, antigen presentation of dendritic cells, differentiation and activation of T helper cells, development and recruitment of eosinophils, and degranulation of mast cells in the early stage. 34 Studies have shown that 35 miR-126 may be involved in the pathogenesis of AR by positively regulating the expression of Treg cytokines and negatively regulating the expression of the Th1 and Th2 cytokines. It can be inferred that these miRNAs also play a key role in AR.…”

Section: Discussionmentioning

confidence: 99%

Analysis of ceRNA Regulatory Mechanism of Rape Pollen Allergy Based on Whole-Transcriptome Sequencing of Peripheral Blood Mononuclear Cells

Wang¹,

Li²,

Wang³

et al. 2023

JAA

View full text Add to dashboard Cite

Background Rape pollen allergy is a common allergic reaction disorder that affects the health and life of patients seriously. The research on ceRNA regulatory network in rape pollen allergy is poor. Methods High throughput whole-transcriptome sequencing was conducted on rape pollen allergic samples and non-allergic samples. Differentially expressed microRNAs (DEmiRNAs), circRNAs (DEcircRNAs), long non-coding RNA (DElncRNAs), mRNA (DEmRNAs) were identified and a ceRNA regulatory network was constructed by Cytoscape. Functional enrichment analyses were performed on DEmRNAs in the ceRNA network. Then, the least absolute shrinkage and selection operator (LASSO) regression model was used to identify characteristic genes for rape pollen allergy. The receiver operating characteristic (ROC) curve was used to evaluate the diagnostic ability of characteristic genes. Results A total of 25 DEmiRNAs, 258 DEcircRNAs, 304 DElncRNAs, and 383 DEmRNAs in the allergic group compared with the non-allergic group were uncovered, respectively. A ceRNA network containing 21 miRNAs, 57 circRNAs, 28 lncRNAs, and 33 mRNAs was generated with 139 nodes and 160 edges. The signal transduction-related processes, immune-related processes, the ion, inorganic substance, and hormone regulation processes were associated with mRNAs in the ceRNA network. The results of pathway enrichment illustrated that mRNAs in the ceRNA were significantly linked to IL-17 signaling pathway, inflammatory mediator regulation of trp channels, GMP-PKG signaling pathway, signaling by GPCR, and GPCR downstream signaling pathway. Then, five characteristic genes (KCNQ3, CCR5, FOSB, CFAP43, and PRKG1) were defined by the LASSO algorithm. The AUC values of these genes indicated that these genes had a powerful discrimination ability in discriminating allergic samples from non-allergic samples. Conclusion Taken together, we revealed the ceRNA regulatory network in rape pollen allergy and excavated five characteristic genes (KCNQ3, CCR5, FOSB, CFAP43, and PRKG1) with the diagnostic value that may be a potential target in diagnosis and treatment.

show abstract

Section: Discussionmentioning

confidence: 99%

Analysis of ceRNA Regulatory Mechanism of Rape Pollen Allergy Based on Whole-Transcriptome Sequencing of Peripheral Blood Mononuclear Cells

Wang¹,

Li²,

Wang³

et al. 2023

JAA

View full text Add to dashboard Cite

show abstract

“…21,22 In addition, the role of miRNAs in inflammation has also received increasing research attention, and it has been demonstrated that disorders linked to excessive inflammation and aberrant IR are connected with miRNA dysregulation. [23][24][25][26] LncRNAs account for 80−90% of all ncRNAs and are a class of ncRNAs over 200 nt in length that cannot encode proteins due to the lack of effective open reading frames. LncRNAs exhibit tissue or cellular specificity, specific subcellular localization, locally conserved sequence motifs, and special spatial secondary structures.…”

Section: Overview Of Ncrnasmentioning

confidence: 99%

“…Numerous studies have demonstrated that miRNAs have significant regulatory functions in various organisms, encompassing cell differentiation, development, proliferation, apoptosis, metabolism, viral infection, and tumorigenesis 21,22 . In addition, the role of miRNAs in inflammation has also received increasing research attention, and it has been demonstrated that disorders linked to excessive inflammation and aberrant IR are connected with miRNA dysregulation 23–26 …”

Section: Overview Of Ncrnasmentioning

confidence: 99%

Advances in noncoding RNA in children allergic rhinitis

Li,

Cui,

et al. 2024

Int Forum Allergy Rhinol

View full text Add to dashboard Cite

Background: A chronic condition that significantly reduces a child's quality of life is allergic rhinitis (AR). The environment and allergens that the body is regularly exposed to can cause inflammatory and immunological reactions, which can change the expression of certain genes Epigenetic changes are closely linked to the onset and severity of allergy disorders according to mounting amounts of data. Noncoding RNAs (ncRNAs) are a group of RNA molecules that cannot be converted into polypeptides. The three main categories of ncRNAs include microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs). NcRNAs play a crucial role in controlling gene expression and contribute to the development of numerous human diseases. Methods: Articles are selected based on Pubmed's literature review and the author's personal knowledge. The largest and highest quality studies were included. The search selection is not standardized. Results: Recent findings indicate that various categories of ncRNAs play distinct yet interconnected roles and actively contribute to intricate gene regulatory networks. Conclusion: This article demonstrates the significance and progress of ncRNAs in children's AR. The database covers three key areas: miRNAs, lncRNAs, and circRNAs. Additionally, potential avenues for future research to facilitate the practical application of ncRNAs as therapeutic targets and biomarkers will be explore.

show abstract

Serum exosomal miR-146a-3p associates with disease severity and efficacy of sublingual immunotherapy in allergic rhinitis

Zhang

Zhu

et al. 2023

International Immunopharmacology

View full text Add to dashboard Cite

Regulatory effects of miRNA-126 on Th cell differentiation and cytokine expression in allergic rhinitis

Cited by 5 publications

References 39 publications

Analysis of ceRNA Regulatory Mechanism of Rape Pollen Allergy Based on Whole-Transcriptome Sequencing of Peripheral Blood Mononuclear Cells

Analysis of ceRNA Regulatory Mechanism of Rape Pollen Allergy Based on Whole-Transcriptome Sequencing of Peripheral Blood Mononuclear Cells

Advances in noncoding RNA in children allergic rhinitis

Serum exosomal miR-146a-3p associates with disease severity and efficacy of sublingual immunotherapy in allergic rhinitis

Contact Info

Product

Resources

About