Serum exosomal miR-146a-3p associates with disease severity and efficacy of sublingual immunotherapy in allergic rhinitis

Zhang, Yanni; Zhu, Kangshun; Lv, Hui; Chen, Jingguo; Yu, Chao; Gao, Tianxi; Yan, Jing; Yang, Fang; Fan, Liancheng; Ren, Xiaoyong; Cui, Xiuhong

doi:10.1016/j.intimp.2023.109777

Cited by 4 publications

(2 citation statements)

References 40 publications

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“…78 In addition, it was found that serum exosome-derived mi-146a-3p could predict the short-and long-term efficacy of SLIT in AR patients. 79 These studies suggest that miRNAs may play an important regulatory role in immunotherapy of AR. This also suggests that ncRNAs will play an increasingly important role in AR immunotherapy in the future and will provide better ideas for the treatment of AR.…”

Section: Ncrna and Ar Immunotherapymentioning

confidence: 98%

“…A study examined the expression of 48 miRNAs in AR patients treated with SCIT and found that some proinflammatory miRNAs were significantly downregulated and several miRNAs regulating the Th1/Th2 balance were upregulated after 6 months of SCIT treatment 78 . In addition, it was found that serum exosome‐derived mi‐146a‐3p could predict the short‐ and long‐term efficacy of SLIT in AR patients 79 . These studies suggest that miRNAs may play an important regulatory role in immunotherapy of AR.…”

Section: Ncrna and Ar Immunotherapymentioning

confidence: 99%

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Advances in noncoding RNA in children allergic rhinitis

Li,

Cui,

et al. 2024

Int Forum Allergy Rhinol

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Background: A chronic condition that significantly reduces a child's quality of life is allergic rhinitis (AR). The environment and allergens that the body is regularly exposed to can cause inflammatory and immunological reactions, which can change the expression of certain genes Epigenetic changes are closely linked to the onset and severity of allergy disorders according to mounting amounts of data. Noncoding RNAs (ncRNAs) are a group of RNA molecules that cannot be converted into polypeptides. The three main categories of ncRNAs include microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs). NcRNAs play a crucial role in controlling gene expression and contribute to the development of numerous human diseases. Methods: Articles are selected based on Pubmed's literature review and the author's personal knowledge. The largest and highest quality studies were included. The search selection is not standardized. Results: Recent findings indicate that various categories of ncRNAs play distinct yet interconnected roles and actively contribute to intricate gene regulatory networks. Conclusion: This article demonstrates the significance and progress of ncRNAs in children's AR. The database covers three key areas: miRNAs, lncRNAs, and circRNAs. Additionally, potential avenues for future research to facilitate the practical application of ncRNAs as therapeutic targets and biomarkers will be explore.

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Section: Ncrna and Ar Immunotherapymentioning

confidence: 98%

Section: Ncrna and Ar Immunotherapymentioning

confidence: 99%