Regulatory effects of insulin-like growth factor-1 on the expression of sensory neuropeptide mRNAs in cultured dorsal root ganglion neurons with excitotoxicity induced by glutamate

Abstract

IGF-1 may exert neuroprotective effects on DRG neurons against Glu-induced excitotoxicity, probably through regulating the expression levels of PPT and CGRP mRNAs.

Noradrenaline regulates substance P release from rat dorsal root ganglion neurons in vitro

“…SP release and SP levels in primary sensory neurons are infl uenced by many factors [17][18][19][20] . A previous study has shown that the α1-adrenoreceptor agonist phenylephrine causes the release of SP from terminals of CAP-sensitive sensory neurons in the lumbar enlargement of the dorsal spinal cord and urinary bladder [5] .…”