Regulatory Effects of Histamine and Histamine Receptor Expression in Human Allergic Immune Responses

Akdiş, Cezmi A.; Jutel, Marek

doi:10.1159/000154858

Cited by 39 publications

(24 citation statements)

References 88 publications

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“…This suggests that histamine exceeds its physiological usefulness during exposure to large amounts of it, and this overwhelms the inactivation mechanisms, causing unwanted effects on blood pressure, vascular tone, and permeability. In addition, there may be differences in the responses of individuals to histamine, based in part on the physiological effects mediated by the 4 known histamine receptors (H 1-4 ), which differ in tissue distribution and affinity for histamine (43,44). Polymorphisms discovered in histamine receptors may also account for some of the physiological differences (45,46).…”

Section: Figurementioning

confidence: 99%

Sphingosine kinase 1 and sphingosine-1-phosphate receptor 2 are vital to recovery from anaphylactic shock in mice

Olivera¹,

Eisner²,

Kitamura³

et al. 2010

J. Clin. Invest.

121

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Sphingosine kinase 1 (SphK1) and SphK2 are ubiquitous enzymes that generate sphingosine-1-phosphate (S1P), a ligand for a family of G protein-coupled receptors (S1PR1-S1PR5) with important functions in the vascular and immune systems. Here we explore the role of these kinases and receptors in recovery from anaphylaxis in mice. We found that Sphk2 -/-mice had a rapid recovery from anaphylaxis. In contrast, Sphk1 -/-mice showed poor recovery from anaphylaxis and delayed histamine clearance. Injection of S1P into Sphk1 -/-mice increased histamine clearance and promoted recovery from anaphylaxis. Adoptive cell transfer experiments demonstrated that SphK1 activity was required in both the hematopoietic and nonhematopoietic compartments for recovery from anaphylaxis. Mice lacking the S1P receptor S1PR2 also showed a delay in plasma histamine clearance and a poor recovery from anaphylaxis. However, S1P did not promote the recovery of S1pr2 -/-mice from anaphylaxis, whereas S1pr2 +/-mice showed partial recovery. Unlike Sphk2 -/-mice, Sphk1 -/-and S1pr2 -/-mice had severe hypotension during anaphylaxis. Thus, SphK1-produced S1P regulates blood pressure, histamine clearance, and recovery from anaphylaxis in a manner that involves S1PR2. This suggests that specific S1PR2 agonists may serve to counteract the vasodilation associated with anaphylactic shock.

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Section: Figurementioning

confidence: 99%

Sphingosine kinase 1 and sphingosine-1-phosphate receptor 2 are vital to recovery from anaphylactic shock in mice

Olivera¹,

Eisner²,

Kitamura³

et al. 2010

J. Clin. Invest.

121

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“…[3][4][5] These mediators are devastating to the asthmatic lung causing, for example, bronchoconstriction. 6,7 In comparison with healthy individuals, the mast cell numbers are increased in the airway smooth muscle 8 and alveolar parenchyma 9 of asthmatics. As a consequence, a high number of mast cells can be activated during allergen exposure, and the symptoms can be severe.…”

Section: Introductionmentioning

confidence: 99%

Lin− CD34hi CD117int/hi FcεRI+ cells in human blood constitute a rare population of mast cell progenitors

Dahlin¹,

Malinovschi²,

Öhrvik³

et al. 2016

Blood

103

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“…differentiation and proliferation of cells, embryonic development, hematopoiesis and wound healing [1] . It plays an important role in acute inflammatory and immediate-type hypersensitivity responses as well as in chronic inflammation and delayed-type allergic reactions.…”

Section: Introductionmentioning

confidence: 99%

Histamine Downregulates the Th1-Associated Chemokine IP-10 in Monocytes and Myeloid Dendritic Cells

Glatzer

Mommert²,

Köther³

et al. 2013

Int Arch Allergy Immunol

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fect was mediated via H 2 R and H 4 R in monocytes and mDC. Conclusion: Monocytes and mDC have similar histamine receptor repertoires with regard to H 1 R, H 2 R and H 3 R, but H 4 R expression is higher on mDC. Histamine stimulation shows similar functional effects on both cell types, i.e., downregulation of TLR3-induced IP-10 production. This might be a new mechanism how histamine fosters a Th2 milieu.

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Regulatory Effects of Histamine and Histamine Receptor Expression in Human Allergic Immune Responses

Cited by 39 publications

References 88 publications

Sphingosine kinase 1 and sphingosine-1-phosphate receptor 2 are vital to recovery from anaphylactic shock in mice

Sphingosine kinase 1 and sphingosine-1-phosphate receptor 2 are vital to recovery from anaphylactic shock in mice

Lin− CD34hi CD117int/hi FcεRI+ cells in human blood constitute a rare population of mast cell progenitors

Histamine Downregulates the Th1-Associated Chemokine IP-10 in Monocytes and Myeloid Dendritic Cells

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