2017
DOI: 10.1016/j.critrevonc.2017.05.008
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Regulatory effects of berberine on microRNome in Cancer and other conditions

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Cited by 82 publications
(69 citation statements)
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“…MiRNAs act as promising biomarkers and drug target for the diagnosis and therapy of kinds of diseases, and natural compounds can regulate the expression of miRNAs. The regulatory effects of berberine, resveratrol, curcumin and polyphenols on non-coding RNAs in cancers, diabetes and other conditions have been discussed in other reviews [67][68][69][70], and here in this report the functions of berberine in epigenetics were summarized in figure 4 and 5. Quercetin is an important a flavonoid, characterized by the presence of a phenyl benzo(c)pyrone-derived structure (Figure 3), commonly existing in kinds of fruits and vegetables like beans, capers, radish leaves, citrus fruits, apples, onions and parsley [71].…”
Section: Micrornas Regulationmentioning
confidence: 97%
“…MiRNAs act as promising biomarkers and drug target for the diagnosis and therapy of kinds of diseases, and natural compounds can regulate the expression of miRNAs. The regulatory effects of berberine, resveratrol, curcumin and polyphenols on non-coding RNAs in cancers, diabetes and other conditions have been discussed in other reviews [67][68][69][70], and here in this report the functions of berberine in epigenetics were summarized in figure 4 and 5. Quercetin is an important a flavonoid, characterized by the presence of a phenyl benzo(c)pyrone-derived structure (Figure 3), commonly existing in kinds of fruits and vegetables like beans, capers, radish leaves, citrus fruits, apples, onions and parsley [71].…”
Section: Micrornas Regulationmentioning
confidence: 97%
“…[80][81][82] In endometrial cancer cells and multiple myeloma cells, BBR inhibited cancer invasion and metastasis by interacting with microRNAs. [83][84][85] In hepatoma cells, BBR mediated the transcriptional activation of p21 and GADD45α by upregulating the expression of miR-23a. 86 In colon cancer cells, BBR down-regulated miR-429 and inhibited E-cadherin expression.…”
Section: Bbr's Other Functions Effects Of Bbr On Micrornamentioning
confidence: 99%
“…BBR can modulate the microbial balance and regulate the mucosal immune system, the JAK/STAT pathway, and the MAPK/ERK pathway so that it blocks F. nucleatummediated colorectal, tumorigenesis in vivo. 36 Moreover, in preclinical models, BBR also enhances the cytotoxicity of clinically used antitumor agents. On the other hand, BBR inhibits cancer metastases by regulating matrix metalloproteinases (MMPs).…”
Section: Source and Biological Function Of Berberinementioning
confidence: 99%