Regulatory effects of berberine on microRNome in Cancer and other conditions

Ayati, Seyed Hasan; Fazeli, Badrieh; Momtazi‐Borojeni, Amir Abbas; Cicero, Arrigo Francesco Giuseppe; Pirro, Matteo; Sahebkar, Amirhossein

doi:10.1016/j.critrevonc.2017.05.008

Cited by 80 publications

(61 citation statements)

References 104 publications

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“…MiRNAs act as promising biomarkers and drug target for the diagnosis and therapy of kinds of diseases, and natural compounds can regulate the expression of miRNAs. The regulatory effects of berberine, resveratrol, curcumin and polyphenols on non-coding RNAs in cancers, diabetes and other conditions have been discussed in other reviews [67][68][69][70], and here in this report the functions of berberine in epigenetics were summarized in figure 4 and 5. Quercetin is an important a flavonoid, characterized by the presence of a phenyl benzo(c)pyrone-derived structure (Figure 3), commonly existing in kinds of fruits and vegetables like beans, capers, radish leaves, citrus fruits, apples, onions and parsley [71].…”

Section: Micrornas Regulationmentioning

confidence: 97%

The Roles of Natural Compounds in Epigenetics

Yang

Chi

Gao

et al. 2018

Natural Product Communications

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Epigenetic modifications include DNA methylation, histone modification, microRNA and lncRNA regulations, and take part in many physiological and pathological processes. Recently, it has been found that natural compounds are essential in regulation of epigenetics. By influencing the expression and activities of genes related with epigenetics and altering the expression and functions of miRNAs, many natural compounds exhibit the biological and pharmaceutical activities in the prevention, diagnosis and treatment of many kinds of human diseases, such as cancer, diabetes and cardiovascular diseases. Here in this review, the effects of several natural compounds on epigenetics and the underlying mechanisms were summarized, providing a new insight into the role of natural compounds.

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Section: Micrornas Regulationmentioning

confidence: 97%

The Roles of Natural Compounds in Epigenetics

Yang

Chi

Gao

et al. 2018

Natural Product Communications

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“…[80][81][82] In endometrial cancer cells and multiple myeloma cells, BBR inhibited cancer invasion and metastasis by interacting with microRNAs. [83][84][85] In hepatoma cells, BBR mediated the transcriptional activation of p21 and GADD45α by upregulating the expression of miR-23a. 86 In colon cancer cells, BBR down-regulated miR-429 and inhibited E-cadherin expression.…”

Section: Bbr's Other Functions Effects Of Bbr On Micrornamentioning

confidence: 99%

<p>The Anti-Cancer Mechanisms of Berberine: A Review</p>

Wang¹,

Liu²,

Du³

et al. 2020

CMAR

128

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Berberine (BBR) has been extensively studied in vivo and vitro experiments. BBR inhibits cell proliferation by regulating cell cycle and cell autophagy, and promoting cell apoptosis. BBR also inhibits cell invasion and metastasis by suppressing EMT and down-regulating the expression of metastasis-related proteins and signaling pathways. In addition, BBR inhibits cell proliferation by interacting with microRNAs and suppressing telomerase activity. BBR exerts its anti-inflammation and antioxidant properties, and also regulates tumor microenvironment. This review emphasized that BBR as a potential antiinflammation and antioxidant agent, also as an effective immunomodulator, is expected to be widely used in clinic for cancer therapy.

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“…BBR can modulate the microbial balance and regulate the mucosal immune system, the JAK/STAT pathway, and the MAPK/ERK pathway so that it blocks F. nucleatummediated colorectal, tumorigenesis in vivo. 36 Moreover, in preclinical models, BBR also enhances the cytotoxicity of clinically used antitumor agents. On the other hand, BBR inhibits cancer metastases by regulating matrix metalloproteinases (MMPs).…”

Section: Source and Biological Function Of Berberinementioning

confidence: 99%

Berberine: A potential adjunct for the treatment of gastrointestinal cancers?

Hesari

Ghasemi

Cicero

et al. 2018

J of Cellular Biochemistry

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Gastrointestinal cancers are among the most prevalent cancers in the general population. Despite effective early diagnostics and intervention, the gastrointestinal cancer-related mortality still remains elevated. Berberine (BBR) is a benzyl tetra isoquinoline alkaloid exracted from several plants. BBR is nontoxic to human normal cells, but suppresses the growth of different tumor cells: melanoma, epidermoid carcinoma, hepatoma, oral carcinoma, glioblastoma, prostatic carcinoma, and gastric carcinoma. In particular, BBR seems to suppress the proliferation of gastrointestinal cancers in a number of preclinical models. Several mechanisms of action have been hypothesized and demonstrated: immunomodulation, inhibition of topoisomerase enzymes, suppression of the EGF receptor, Her2/neu, and the VEGF receptor, induction of p53, Cip1/p21, Kip1/p27, Rb expression, induction of apoptosis (by regulation of MMPs pathway, caspases, Bax, and Smac/DIABLO), inhibition of arylamin N-acetyltransferase activity, and regulation of microRNAs expression. The aim of this review is to summarize the pharmacological effects of BBR on animal and human gastrointestinal cancers.

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Regulatory effects of berberine on microRNome in Cancer and other conditions

Cited by 80 publications

References 104 publications

The Roles of Natural Compounds in Epigenetics

The Roles of Natural Compounds in Epigenetics

<p>The Anti-Cancer Mechanisms of Berberine: A Review</p>

Berberine: A potential adjunct for the treatment of gastrointestinal cancers?

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