Regulatory defense of the exercise-induced weight elevation in hamsters

Borer, Katarina T.; Kooi, Alice A.

doi:10.1016/s0091-6773(75)91332-2

Cited by 24 publications

(12 citation statements)

References 17 publications

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“…Instead, running stimulates growth, which was shown first by increased body lengths (4) and later strongly supported by bone measurements on radiographs (8), as well as elevated growth hormone levels in exercising individuals (6). According to this running-induced impact, the higher body weight was shown to be defended after a temporary food restriction (7). Also in Syrian hamsters, photoperioddependent gonadal atrophy is reduced (17), and hibernation is inhibited (30), due to running.…”

mentioning

confidence: 98%

Wheel running affects seasonal acclimatization of physiological and morphological traits in the Djungarian hamster (Phodopus sungorus)

Scherbarth¹,

Rozman²,

Klingenspor³

et al. 2007

American Journal of Physiology-Regulatory, Integrative and Comp

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Wheel running was previously shown to influence body mass and torpor in short-day-acclimatized Djungarian hamsters (Phodopus sungorus). To determine whether the exercise-induced effect on body mass depends on the annual phase, hamsters were exposed to the natural change in photoperiod and given access to a running wheel (RW), either before, in the middle of, or at the end of the descending body mass trajectory during seasonal acclimatization. Due to wheel running, the seasonal weight cycle was prevented or aborted by abruptly rising body mass, resulting in a weight appropriate for summer, despite exposure to short days. Torpor was inhibited, and testicular recrudescence was advanced, compared with controls. In contrast, the change into winter fur remained unaltered. Analysis of body composition and plasma leptin revealed a low body fat mass in RW hamsters, not only in winter but also in summer, suggesting a lack of seasonal adiposity. Chronic leptin infusion in winter only decreased body mass in RW individuals, although their relative body fat mass probably was even lower than in sedentary hamsters. A constantly low body fat mass is conceivably reflecting an exercise-dependent change in metabolism, consistent with increased bone mineral content and density in RW hamsters. Additionally, bone area was increased, again supported by elongated vertebral columns. Together, the results show a striking effect of wheel running on body composition and the seasonal pattern of body mass, and they suggest that the photoperiodic regulation of body mass is regulated differently than the reproductive and pelage responses.

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mentioning

confidence: 98%

Wheel running affects seasonal acclimatization of physiological and morphological traits in the Djungarian hamster (Phodopus sungorus)

Scherbarth¹,

Rozman²,

Klingenspor³

et al. 2007

American Journal of Physiology-Regulatory, Integrative and Comp

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“…One can accelerate ponderal and linear growth in adult hamsters of either sex by exposure to voluntary disc exercise. This manipulation produces hyperphagia and accelerated ponderal [Borlr. 1974; Borer and Kooi, 1975] and skeletal growth [Borer and Kuhns, 1977] in hamsters which have attained the asymptotic phase of growth [Borer and K aplan, 1977], A role for the septal (SEP) area in the neuroendocrine control of growth was suggested by reports of accelerated weight gain fol lowing lesions of this area in adult hamsters of either sex [Hobbs et at.. 1972;Janzen and Bunnell, 1976;Matalka, 1967]. To test this hypothesis, we have measured ponderal and skeletal growth, body fat content, food and water intake, serum GH and insulin concentrations and GH content and concentration in the anterior pituitary in intact and hypophysectomized hamsters with or without electrolytic damage to the SEP area.…”

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confidence: 99%

The Role of the Septal Area in the Neuroendocrine Control of Growth in the Adult Golden Hamster

et al. 1977

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Somatic, endocrine and behavioral correlates of growth were measured in intact and hypophysectomized adult hamsters with or without electrolytic damage to the rostral septal area. Septal (SEP) lesions significantly increased somatic growth rate, food consumption and serum concentration of growth hormone (GH) and insulin. Pituitary GH content and concentration were reduced in lesioned hamsters. None of these changes were found in hypophysectomized hamsters with SEP lesions. SEP lesions did not affect the percentage of body fat. These data suggest that the septum or adjacent fibers of passage inhibit growth in adult hamsters.

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“…Evidence for such differences has been accumulating. Voluntary disc exercise accelerates ponderal [Borer, 1974;Borer and Kooi, 1975] and skeletal growth in the hamster [Borer and K u h n s. 1977] but not in the rat (Borer. R en fro , C rapsey, and Satinoff, unpublished data, 1976). Electrolytic de struction of rostral septal area leads to significant acceleration of skeletal and ponderal growth and to oversecretion of GH in the hamster but not in the rat [Brow n et al.…”

Section: Discussionmentioning

confidence: 99%

“…A decrease in the scrum GH concentration was ob served in hamsters at the age 2 to 16 days. Pituitary GH content and concentration increased steadily between 9 and 120 days of age.Hamsters which have reached the slow asymptotic phase of growth can be induced to grow rapidly by exposure to free disc exercise [Borer, 1974;Borer and Kooi, 1975; Borer and K a pl a n , 1977; Borer and K u h n s. 1977] or by electrolytic destruction of rostral medial septal area of the brain . We have developed a heterologous double-anti body RIA method for the measurement of hamster growth hormone (GH) to determine whether changes in serum GH concentrations accompany the accelerated ponderal and skeletal growth observed after these manipulations.…”

mentioning

confidence: 99%

A Heterologous Radioimmunoassay Method for Measurement of Hamster Growth Hormone

Borer¹,

Kelch

1978

Neuroendocrinology

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A heterologous radioimmunoassay (RIA) for determination of hamster growth hormone (GH) is described which involves the use of radioiodinated rat GH (NIAMDD Rat GH-I-2), antiserum to rat GH (NIAMDD Anti-Rat-GHS-3), a standard hamster anterior pituitary homogenate (SHAP), as well as purified hamster GH (AFP-1595-B). This RIA was shown to be a reliable, sensitive, and specific method for measurement of hamster GH. With this method we have determined the effects of stress and hypophysectomy on serum GH concentrations as well as changes in serum GH concentration, and pituitary GH content and concentration as a function of hamster age. In contrast to responses noted in rats, the stress of ether anesthesia and i.e. puncture caused significant increases in serum GH. A decrease in the serum GH concentration was observed in hamsters at the age 2 to 16 days. Pituitary GH content and concentration increased steadily between 9 and 120 days of age.

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Regulatory defense of the exercise-induced weight elevation in hamsters

Cited by 24 publications

References 17 publications

Wheel running affects seasonal acclimatization of physiological and morphological traits in the Djungarian hamster (Phodopus sungorus)

Wheel running affects seasonal acclimatization of physiological and morphological traits in the Djungarian hamster (Phodopus sungorus)

The Role of the Septal Area in the Neuroendocrine Control of Growth in the Adult Golden Hamster

A Heterologous Radioimmunoassay Method for Measurement of Hamster Growth Hormone

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