Regulatory Components of Oxidative Stress and Inflammation and Their Complex Interplay in Carcinogenesis

Dharshini, Loganathan Chandramani Priya; Rasmi, Rajan Radha; Kathirvelan, C.; Kumar, K. Ashok; Muthukrishnan, Saradhadevi; Sakthivel, Kunnathur Murugesan

doi:10.1007/s12010-022-04266-z

Cited by 23 publications

(18 citation statements)

References 161 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Excessive oxidative stress can detrimentally impact the immune system. For instance, elevated levels of oxidative stress may precipitate apoptosis or impair functionality in immune cells, thereby diminishing the efficacy of immune infiltration ( 60 – 62 ). Moreover, oxidative stress may facilitate the proliferation and functional enhancement of immune suppressive cells within the tumor microenvironment, such as TAMs, further inhibiting the immune cells’ action against tumors ( 63 , 64 ).…”

Section: Discussionmentioning

confidence: 99%

Experimentally validated oxidative stress -associated prognostic signatures describe the immune landscape and predict the drug response and prognosis of SKCM

Rong,

Su,

Jia

et al. 2024

Front. Immunol.

View full text Add to dashboard Cite

BackgroundSkin Cutaneous Melanoma (SKCM) incidence is continually increasing, with chemotherapy and immunotherapy being among the most common cancer treatment modalities. This study aims to identify novel biomarkers for chemotherapy and immunotherapy response in SKCM and explore their association with oxidative stress.MethodsUtilizing TCGA-SKCM RNA-seq data, we employed Weighted Gene Co-expression Network Analysis (WGCNA) and Protein-Protein Interaction (PPI) networks to identify six core genes. Gene co-expression analysis and immune-related analysis were conducted, and specific markers associated with oxidative stress were identified using Gene Set Variation Analysis (GSVA). Single-cell analysis revealed the expression patterns of Oxidative Stress-Associated Genes (OSAG) in the tumor microenvironment. TIDE analysis was employed to explore the association between immune therapy response and OSAG, while CIBERSORT was used to analyze the tumor immune microenvironment. The BEST database demonstrated the impact of the Oxidative Stress signaling pathway on chemotherapy drug resistance. Immunohistochemical staining and ROC curve evaluation were performed to assess the protein expression levels of core genes in SKCM and normal samples, with survival analysis utilized to determine their diagnostic value.ResultsWe identified six central genes associated with SKCM metastasis, among which the expression of DSC2 and DSC3 involved in the oxidative stress pathway was closely related to immune cell infiltration. DSC2 influenced drug resistance in SKMC patients. Furthermore, downregulation of DSC2 and DSC3 expression enhanced the response of SKCM patients to immunotherapy.ConclusionThis study identified two Oxidative Stress-Associated genes as novel biomarkers for SKCM. Additionally, targeting the oxidative stress pathway may serve as a new strategy in clinical practice to enhance SKCM chemotherapy and sensitivity.

show abstract

Section: Discussionmentioning

confidence: 99%

Experimentally validated oxidative stress -associated prognostic signatures describe the immune landscape and predict the drug response and prognosis of SKCM

Rong,

Su,

Jia

et al. 2024

Front. Immunol.

View full text Add to dashboard Cite

show abstract

“…Regarding the SCD, it participates in the biosynthesis of monounsaturated fatty acids, holding a pivotal role in lipid metabolism. Its associations with pathways related to fatty acid metabolism, lipid biosynthesis, and energy homeostasis are well-documented ( 16 ). Over the last decade, however, certain oil-based products have been examined for their favorable role in lipid biosynthesis ( 37 , 38 ).…”

Section: Discussionmentioning

confidence: 99%

Hepatotoxicity assessment of innovative nutritional supplements based on olive-oil formulations enriched with natural antioxidants

Prodromou,

Chatzopoulou,

Saiti

et al. 2024

Front. Nutr.

View full text Add to dashboard Cite

IntroductionThis study focuses on the assessment of extra virgin olive-oil and olive fruit-based formulations enriched with natural antioxidants as potential nutritional supplements for alleviating symptoms and long-term consequences of illnesses whose molecular pathophysiology is affected by oxidative stress and inflammation, such as Alzheimer’s disease (AD).MethodsBesides evaluating cell viability and proliferation capacity of human hepatocellular carcinoma HepG2 cells exposed to formulations in culture, hepatotoxicity was also considered as an additional safety measure using quantitative real-time PCR on RNA samples isolated from the cell cultures and applying approaches of targeted molecular analysis to uncover potential pathway effects through gene expression profiling. Furthermore, the formulations investigated in this work contrast the addition of natural extract with chemical forms and evaluate the antioxidant delivery mode on cell toxicity.ResultsThe results indicate minimal cellular toxicity and a significant beneficial impact on metabolic molecular pathways in HepG2 cell cultures, thus paving the way for innovative therapeutic strategies using olive-oil and antioxidants in dietary supplements to minimize the long-term effects of oxidative stress and inflammatory signals in individuals being suffered by disorders like AD.DiscussionOverall, the experimental design and the data obtained support the notion of applying innovative molecular methodologies and research techniques to evidently advance the delivery, as well as the scientific impact and validation of nutritional supplements and dietary products to improve public health and healthcare outcomes.

show abstract

“…Long-term hyperglycemia in patients with diabetes activates the growth factor cascade in the body through neurohumoral regulation, thereby increasing the production of inflammatory cytokines and chemokines. Studies have demonstrated that diabetes can promote the secretion of VEGF, IL, TNF, NF-kB, and other inflammatory factors and chemokines, and these are closely related to the occurrence of tumors 98 , 99 ( Figure 2 ). Additionally, NF-kB is a regulatory factor that inhibits apoptosis.…”

Section: The Underlying Mechanisms Of Diabetes and Thyroid Cancermentioning

confidence: 99%

Diabetes Mellitus and Thyroid Cancers: Risky Correlation, Underlying Mechanisms and Clinical Prevention

Wu,

Zhang,

Zou

et al. 2024

DMSO

View full text Add to dashboard Cite

The incidences of thyroid cancer and diabetes are rapidly increasing worldwide. The relationship between thyroid cancer and diabetes is a popular topic in medicine. Increasing evidence has shown that diabetes increases the risk of thyroid cancer to a certain extent. This mechanism may be related to genetic factors, abnormal thyroid-stimulating hormone secretion, oxidative stress injury, hyperinsulinemia, elevated insulin-like growth factor-1 levels, abnormal secretion of adipocytokines, and increased secretion of inflammatory factors and chemokines. This article reviews the latest research progress on the relationship between thyroid cancer and diabetes, including the association between diabetes and the risk of developing thyroid cancer, its underlying mechanisms, and potential anti-thyroid cancer effects of hypoglycemic drugs. It providing novel strategies for the prevention, treatment, and improving the prognosis of thyroid cancer.

show abstract

Regulatory Components of Oxidative Stress and Inflammation and Their Complex Interplay in Carcinogenesis

Cited by 23 publications

References 161 publications

Experimentally validated oxidative stress -associated prognostic signatures describe the immune landscape and predict the drug response and prognosis of SKCM

Experimentally validated oxidative stress -associated prognostic signatures describe the immune landscape and predict the drug response and prognosis of SKCM

Hepatotoxicity assessment of innovative nutritional supplements based on olive-oil formulations enriched with natural antioxidants

Diabetes Mellitus and Thyroid Cancers: Risky Correlation, Underlying Mechanisms and Clinical Prevention

Contact Info

Product

Resources

About