Regulatory B cells play a key role in immune system balance

Berthelot, Jean‐Marie; Jamin, Christophe; Amrouche, Kahina; Goff, Benoît Le; Maugars, Yves; Youinou, Pierre

doi:10.1016/j.jbspin.2012.04.010

Cited by 92 publications

(79 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, B cells have been subdivided into discrete Beffector^and Bregulatory^subsets according to the production of cytokines (Rosser et al 2014). Regulatory B cells, which can be divided into Br1 cells expressing IL-10, Br3 cells expressing TGF-beta and B-Foxp3 cells (Berthelot et al 2013), may act earlier than regulatory T cells do and may predominantly control autoimmune, allergic diseases, cancer, transplant, and parasitology (Mauri and Bosma 2012;Mauri and Ehrenstein 2008). Previously, it has been reported that chronic S. mansoni infections might suppress allergic airway inflammation, depending on IL-10 (Smits et al 2007).…”

Section: Discussionmentioning

confidence: 99%

“…The culture supernatants were collected after 72 h to detect IFN-γ, IL-17, and IL-4 by ELISA. Data are expressed as mean±SEM of three independent experiments with six mice per group in each experiment Regulatory B cells play a key role in immune system balance (Berthelot et al 2013). It has been demonstrated that IL-10 expression by endogenous B cells, and especially Bregs, is central to sustain Treg populations in vivo (Rosser et al 2014).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

B10 cells induced by Schistosoma japonicum soluble egg antigens modulated regulatory T cells and cytokine production of T cells

Fang

Xian

et al. 2015

Parasitol Res

View full text Add to dashboard Cite

A distinct subset of B cells, also known as regulatory B cells, can negatively regulate T cell immune responses, but the role of these cells in schistosomiasis has not been clarified. Soluble egg antigen (SEA) and soluble adult worm antigen preparation (SWAP), which are two important antigen sources during Schistosoma japonicum infection, both can induce Th1, Th2, Th17, and Treg cells and the corresponding cytokines. However, whether they can induce the production of regulatory B cells and the regulatory function of schistosome-induced regulatory B cells remains unclear. In our studies, we first analyzed the production of regulatory B cells stimulated by SEA or SWAP using flow cytometry and enzyme-linked immunosorbent assay, and observed these cells in mice immunized by SEA or SWAP. Then, B10 cells sorted by MicroBeads were co-cultured with CD4(+) T cells, and the proportion of Treg cells were detected. At the same time, the IFN-γ, IL-4, and IL-17 levels in the culture supernatant were measured. The results showed that B10 cells were preferentially induced by SEA in vitro, and B10 could also be induced in mice immunized by SEA. SEA-induced B10 cells promoted the expansion of regulatory T cells and induced IL-4 secretion, but inhibited IL-17 production. These findings reveal that the generation of B10 cells is determined by parasitic antigen, and suggest the function of B10 cell induced by SEA. This study significantly contributes to the understanding of the immune regulatory role in schistosomiasis and may help protect hosts from infection.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

B10 cells induced by Schistosoma japonicum soluble egg antigens modulated regulatory T cells and cytokine production of T cells

Fang

Xian

et al. 2015

Parasitol Res

View full text Add to dashboard Cite

show abstract

“…The most prominent characteristic is secretion of immunosuppressive IL-10 and this phenotype is therefore referred to as Br1 cells (by analogy to Tr1 cells), both in mice and in humans (Berthelot et al, 2013). However, activation of Br1 cells may chiefly involve interactions between TLRs and MAMPs, rather than between antigen and BCR.…”

Section: Innate Properties Of Mucosal Pcsmentioning

confidence: 99%

The Mucosal B Cell System

Brandtzæg

2015

Mucosal Immunology

View full text Add to dashboard Cite

“…Emerging significant evidence indicates that B cells can also actively modulate immune responses through mechanisms that do not directly involve the production of antibodies [2]. These B cells are functionally defined ''regulatory B cells,'' or Breg, possibly acting earlier in the immune response than Treg cells [5]. Expansion of Bregs inhibits harmful immune responses to chronic inflammation by suppressing effector T cells, either through contactdependent or independent mechanisms [6].…”

Section: Regulatory B Cell Response In Hbv Infectionmentioning

confidence: 99%

Bregs in Chronic HBV: Is It Time for Bragging Rights?

Alatrakchi

2015

Dig Dis Sci

View full text Add to dashboard Cite

Regulatory B cells play a key role in immune system balance

Cited by 92 publications

References 58 publications

B10 cells induced by Schistosoma japonicum soluble egg antigens modulated regulatory T cells and cytokine production of T cells

B10 cells induced by Schistosoma japonicum soluble egg antigens modulated regulatory T cells and cytokine production of T cells

The Mucosal B Cell System

Bregs in Chronic HBV: Is It Time for Bragging Rights?

Contact Info

Product

Resources

About