Abstract:Urinary bladder cancer, the fifth most common cancer in the United States, is largely caused by exposure to toxic chemicals including those from smoking. Polymorphisms in the RGS6 gene leading to increased RGS6 translation are associated with a pronounced reduction in the risk of bladder cancer, especially among smokers. We employed a RGS6‐/‐ mouse line to interrogate the role of RGS6 in BBN‐induced bladder carcinogenesis, a model that closely resembles human invasive bladder cancer. RGS6 is highly expressed i… Show more
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