Regulation of Vascular Endothelial Growth Factor Signaling by miR-200b

miR-200b and Cancer/Testis Antigen CAGE Form a Feedback Loop to Regulate the Invasion and Tumorigenic and Angiogenic Responses of a Cancer Cell Line to Microtubule-targeting Drugs

“…miR-200b regulates VEGF signaling and angiogenesis (22,41). miR-200b negatively regulates the expression of VEGF and PAI-1 (Fig.…”

MicroRNA Regulation of Angiogenesis

“…Indeed, hypoxia-associated induction of Ets-1 and pro-angiogenic behavior is blunted upon delivery of exogenous miR-200b [78]. miR-200b not only targets Ets-1 but also silences proteins essential for VEGF signaling such as VEGF [79] and VEGFR2 [80,81]. In human and murine diabetic retina, miR-200b is significantly downmodulated, which is associated with VEGF overproduction.…”

Angiogenic Signaling and Structural Abnormalities in Tumors

“…It soon turned out that miRNAs can be differentially expressed in various tumor types, either benign or malignant [58], and their effect on tumor progression might be connected with the modulation of development of new blood vessels, both via promoting angiogenesis (angiomirs) or through its inhibition (anti-angiomirs) [59]. Anti-angiomirs, including miR-15a, miR-16, miR-125b, miR-199a, or miR-200b target proangiogenic VEGF and their expression could be decreased in different tumor types including lymphomas, multiple myelomas, lung, colorectal, hepatocellular, ovarian, oral, and breast cancer [60][61][62]. VEGF may be not only inhibited by miRNAs, but it can also be activated by them.…”