miR-200b and Cancer/Testis Antigen CAGE Form a Feedback Loop to Regulate the Invasion and Tumorigenic and Angiogenic Responses of a Cancer Cell Line to Microtubule-targeting Drugs

Kim, Youngmi; Park, Deokbum; Kim, Hyuna; Choi, Munseon; Lee, Hansoo; Lee, Yun Sil; Choe, Jongseon; Kim, Young Myeong; Jeoung, Dooil

doi:10.1074/jbc.m113.502047

Cited by 35 publications

(59 citation statements)

References 49 publications

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“…Western Blot Analysis-Western blot analysis, immunoprecipitation, and cellular fractionation were performed according to standard procedures (18). For analysis of proteins from tumor tissues, frozen samples were ground to a fine powder using a mortar and pestle over liquid nitrogen.…”

Section: Methodsmentioning

confidence: 99%

“…Malme3M R cells that stably express miR-200b, miR-217, or miR-335 were also selected by G418 (400 g/ml). Human umbilical vein endothelial cells (HUVECs) were isolated from human umbilical cord veins according to standard procedures (18).…”

Section: Methodsmentioning

confidence: 99%

“…miRNA databases predict that miR-217 regulates the expression of CAGE, a cancer/testis antigen, and VEGFA (data not shown). CAGE enhances the invasion, migration, and the expression of VEGF and enhances tumor-induced angiogenesis (18). CAGE regulates the expression of cyclin D in an AP1 and E2F-dependent manner (33).…”

Section: Targetscan Analysis Predicts That Mir-326 Acts As a Negativementioning

confidence: 99%

“…miR-27a reverses the multidrug resistance phenotype by regulating the expression of MDR1 and ␤-catenin (17). miR-200b forms a feedback loop with CAGE, a cancer/testis antigen, and it regulates the invasion and tumorigenic and angiogenic responses in a cancer cell line to microtubule-targeting drugs (18). The miR-29 family functions as a tumor suppressor (19,20).…”

mentioning

confidence: 99%

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miR-326-Histone Deacetylase-3 Feedback Loop Regulates the Invasion and Tumorigenic and Angiogenic Response to Anti-cancer Drugs

Kim

Park

et al. 2014

Journal of Biological Chemistry

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Targetscan Analysis Predicts That Mir-326 Acts As a Negativementioning

confidence: 99%

mentioning

confidence: 99%

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miR-326-Histone Deacetylase-3 Feedback Loop Regulates the Invasion and Tumorigenic and Angiogenic Response to Anti-cancer Drugs

Kim

Park

et al. 2014

Journal of Biological Chemistry

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“…In the meantime, other researchers also reported that miR-200c promotes mesodermal specification while repressing neuroectodermal differentiation from ESCs [95], suggesting that miR-200c may play a cell-autonomous role in mediating EC differentiation from stem cells. Interestingly, miR-200b displays an antiangiogenic activity in tumor and in embryonic vascular development [96,97], partially through repressing the crucial endothelial lineage related transcription factor E26 oncogene homolog 1 (Ets-1) [98]. This may reflect the distinct functions and dynamic regulation of miR-200 family members in EC differentiation, behaviors and embryonic vascular development at different stages.…”

Section: Mir-200 Familymentioning

confidence: 99%

MicroRNAs in Endothelial Development and Differentiation

Yang¹

2014

J Stem Cell Res Ther

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Endothelial integrity or homeostasis is not only essential for regulating arterial activity and vascular tone under physiological conditions, but also critical for triggering various cardiovascular diseases including atherosclerosis and balloon angioplasty if such a balance has been impaired. Moreover, endothelial cell development and differentiation are key steps during embryogenesis and involves co-ordinations of diverse signaling molecules and transcription factors. Therefore, characterizing the molecular mechanisms underlying endothelial differentiation and development will not only improve our understanding of pathogenesis of vascular disease, but also facilitate our ability in generation of vessels cells from pluripotent stem cells for therapeutic purpose. MicroRNAs, a class of small, non-coding RNAs, have been extensively implicated in the regulation of various aspects of biological processes such as embryonic development, tissue/organ homeostasis, and metabolism, as well as almost all the human disease, particularly cancers and cardiovascular diseases. Accumulating evidence has implicated that microRNAs play an important role in regulation of endothelial development, phenotype and function. In this review, we will summarize new findings from recent studies in this field and discuss our current understanding of how microRNAs regulate endothelial development and differentiation from stem cells.

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The expression of melanoma-associated antigen A (MAGE-A) in oral squamous cell carcinoma: an evaluation of the significance for tumor prognosis

Trippel

Halling

Heymann

et al. 2019

Oral Maxillofac Surg

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miR-200b and Cancer/Testis Antigen CAGE Form a Feedback Loop to Regulate the Invasion and Tumorigenic and Angiogenic Responses of a Cancer Cell Line to Microtubule-targeting Drugs

Cited by 35 publications

References 49 publications

miR-326-Histone Deacetylase-3 Feedback Loop Regulates the Invasion and Tumorigenic and Angiogenic Response to Anti-cancer Drugs

miR-326-Histone Deacetylase-3 Feedback Loop Regulates the Invasion and Tumorigenic and Angiogenic Response to Anti-cancer Drugs

MicroRNAs in Endothelial Development and Differentiation

The expression of melanoma-associated antigen A (MAGE-A) in oral squamous cell carcinoma: an evaluation of the significance for tumor prognosis

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