“…15,22 Here, 22 human esophageal cancer-related proteins that have been reported as the upstream interacting partners of YAP were compiled in supporting information Table S1; they are functionally diverse, including signal transduction proteins (PRRG4 and PTCH1), protein kinases (LATS1/2 and ErbB4), transcription factors/ modulators (TP73, SMAD1 and RUNX1/2/3), phosphatases (PTPN14), scaffolding proteins (DVL1/2/3), and others (WBP1/2, AMOT and AMOTL1/2). 21,[23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41] The canonical forms of primary sequences of these YAP-partner proteins were retrieved from the UniProt database, 42 from which totally 106 decapeptide segments containing PRM motif [P/L]Px[Y/P] were identified, including 34 PPxY-containing segments, 48 PPxP-containing segments, 6 LPxYcontaining segments, and 18 LPxP-containing segments; they were considered as the potential recognition site candidates of YAP WW1/2 domains for subsequent analysis.…”