Regulation of the sequencing in sterol biosynthesis

Nes, William R.

doi:10.1007/bf02538391

Cited by 15 publications

(7 citation statements)

References 62 publications

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“…The synthesis, distribution, and function of sterol lipids in yeast has been an area of intensive investigation for many years. The bulk of the research effort has been devoted to elucidating the pathway of sterol synthesis, with many investigators suggesting intermediates and alternate routes for the formation of ergosterol (3,5,12,15,19,20,30). Although unanimity among authors on the respective position and importance of many of these intermediates in the pathway has not been attained, there is reasonable agreement for the general pathway shown in Fig.…”

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confidence: 93%

Effect of Altered Sterol Composition on Growth Characteristics of Saccharomyces cerevisiae

Thompson

Parks

1974

J Bacteriol

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The function of sterols in mitochondrial structures of yeast was examined. Sterol mutant strains were employed to examine the effects of altered sterolic content on optimal and permissive growth temperatures in respiring and fermenting cultures. Although fermentative growth was unaffected by sterol composition, a definite decrease in both the optimal and the permissive growth temperatures of respiring cultures was observed when ergosterol was replaced by A8l9), 22-ergostadiene-3#-ol. In vitro studies showed a similar decrease in mem

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confidence: 93%

Effect of Altered Sterol Composition on Growth Characteristics of Saccharomyces cerevisiae

Thompson

Parks

1974

J Bacteriol

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“…Not discussed, but nevertheless interesting, is the possibility that the nonmetabolic role of sterols implies a very long existence for some molecules as they pass in and out of various life forms. Since most of the sterol in nature appears to function nonmetabolically, the total amount of sterol may be increasing in the world and some, actually present in current organisms, could conceivably be as old (10 9 years) as the origin of the biosynthetic pathway (5). While most, but by no means all, mammalian sterol is converted to bile acid (4), the fate of sterol in the majority of plants, lower animals, and microbes is not well understood.…”

Section: Introductionmentioning

confidence: 99%

Role of sterols in membranes

Nes

1974

Lipids

263

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Sterols, or in rare cases structurally similar molecules, are biosynthesized or at least required by all eucaryotic organisms, as well as by many procaryotic ones, regardless of their status as plants, animals, or protista. This information, together with quantitative, structural, metabolic, and other data is reviewed. It is interpreted to mean that the primary role sterols play in nature is a nonmetabolic one as architectural components of membranes and that this role can be played, but less well, by other molecules which approximate the steroidal structure. The biosynthetic process should, therefore, and actually does not appear to be correlatable with this role, which, in turn, is correlatable with phylogenesis. The Δ24‐reduction‐alkylation bifurcation, for instance appears to be interrelated profoundly with the evolutionary differentiation of the animal from the plant kingdom.

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“…117 Many cyanopeptolins act as protease inhibitors, with micropeptin T20 possessing an IC 50 of 2.5 nmol l À1 , and numerous others possessing IC 50 s in the low micromolar range. A third cluster was sequenced from a Planktothrix strain, coding for the sulfated cyanopeptolin 1138 (51). 119 The depsipeptide is constructed using the standard NRPS machinery by genes apdA, B, and D, which contained two, four, and one NRPS modules, respectively.…”

Section: Cyanopeptolinsmentioning

confidence: 99%