Regulation of the plasma non-esterified fatty acid concentration in the postprandial state

Frayn, Keith N.; Summers, L. K. M.; Fielding, Barbara A.

doi:10.1079/pns19970071

Cited by 53 publications

(40 citation statements)

References 44 publications

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“…We hypothesized that the feeding regimen eliciting the greatest reduction in NEFA concentration (i.e., meal feeding) would result in the lowest amount of these fatty acids being used for VLDL-TAG synthesis. This hypothesis was based on studies demonstrating a greater insulin response and R a NEFA suppression after consumption of increased carbohydrate loads (25)(26)(27). In the present study, no significant difference in concentration of NEFAs, absolute NEFA 16:0 (AUC), or percent VLDL-TAG from NEFAs was found between the two feeding regimens, even though the meal-feeding insulin concentration was significantly greater.…”

Section: Discussioncontrasting

confidence: 39%

Increased Dietary Substrate Delivery Alters Hepatic Fatty Acid Recycling in Healthy Men

2005

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Sources of fatty acids flowing to the liver may be used for triacylglycerol (TAG) synthesis. Our objective was to quantify contributions of nonesterified fatty acids (NEFAs), de novo lipogenesis, and dietary fatty acids to VLDL-TAG in the fed state after meal feeding in healthy subjects (n ‫؍‬ 6). The effect of substrate delivery rate was also determined by comparison with data obtained under a continuous-feeding regimen. A liquid diet was administered by mouth or via feeding tube. Contributions of NEFAs, de novo lipogenesis, and dietary fatty acids to VLDL-TAG were quantified using stable isotopes and gas chromatography-mass spectrometry.

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Section: Discussioncontrasting

confidence: 39%

Increased Dietary Substrate Delivery Alters Hepatic Fatty Acid Recycling in Healthy Men

2005

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“…Lipoprotein lipase action is stimulated by a postprandial increase in insulin levels and, in the presence of an increased inflow of dietary TAG, not all NEFA mobilized from dietary TAG are 'trapped' in the adipose tissue through the esterification process and 'leak' into the circulation (Frayn et al 1997). The proportion of the lipoprotein lipase-derived NEFA in plasma increases with time, peaks at about 3-5 h after the meal and reaches >80% of the total plasma NEFA (Frayn et al 1997).…”

Section: Postprandial Statementioning

confidence: 99%

Physiological regulation of NEFA availability: lipolysis pathway

Štich

Berlan

2004

Proc. Nutr. Soc.

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Plasma NEFA are an important energy substrate and, furthermore, play a key role in the induction of insulin resistance in the body. The availability of NEFA is determined predominantly by their mobilization from adipose tissue triacylglycerol stores by the process of lipolysis. Adipose tissue lipolysis in man is regulated by a number of hormonal and paracrine and/or autocrine signals. The main hormonal signals may be represented by catecholamines, insulin, growth hormone, natriuretic peptides and some adipocytokines. The absolute levels and relative importance and contribution of these signals vary in different physiological situations, with diet and physical exercise being the main physiological variables that affect the hormonal signalling. Thus, modulations in hormonal signals induce an increase in NEFA mobilization in the post-absorptive state and during an acute bout of exercise, and suppress NEFA mobilization in the postprandial state. In addition, hormonal regulation is modified by long-term interventions in energy balance, such as dietary restriction and/or physical training, and is disturbed in some pathological states, such as obesity or diabetes. The question that remains is whether disturbances in lipolysis regulation in obese and diabetic subjects may be ‘corrected’ by the long-term interventions in diet and physical activity.

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“…These would include excessive VLDL-triacylglycerol secretion, stimulation of hepatic glucose production and impaired hepatic insulin clearance (hence, systemic hyperinsulinaemia). 2,3 This makes a very attractive hypothesis, especially in the light of consistent demonstrations that`visceral fat' is more responsive to lipolytic stimuli in vitro than subcutaneous fat. 4 Recently this has been termed the`portal theory'.…”

Section: Seidell and Bouchardmentioning

confidence: 99%

Visceral fat in relation to health: is it a major culprit or simply an innocent bystander?

Frayn¹,

Samra²,

Summers³

1997

Int J Obes

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Regulation of the plasma non-esterified fatty acid concentration in the postprandial state

Cited by 53 publications

References 44 publications

Increased Dietary Substrate Delivery Alters Hepatic Fatty Acid Recycling in Healthy Men

Increased Dietary Substrate Delivery Alters Hepatic Fatty Acid Recycling in Healthy Men

Physiological regulation of NEFA availability: lipolysis pathway

Visceral fat in relation to health: is it a major culprit or simply an innocent bystander?

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