Regulation of the exercise-induced expression of the monocarboxylate transporters MCT1 and MCT4 in skeletal muscle

Hamada, Taku; Takimoto, Masaki

doi:10.7600/jpfsm.2.85

Cited by 6 publications

(2 citation statements)

References 68 publications

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“…Furthermore, other factors, such as intensity of the exercise, can regulate the changes in MCT [35,36]. Kitaoka et al [16] observed that incremental exercise increased the amount of MCT1 in the gluteus medius muscle of Thoroughbreds, but after 24 hours, there was no difference detected compared with the baseline.…”

Section: Discussionmentioning

confidence: 99%

Quantification of MCT1 and CD147 in Red Blood Cells of Arabian and Quarter Horses

Regatieri

Almeida

Neto

et al. 2016

Journal of Equine Veterinary Science

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Section: Discussionmentioning

confidence: 99%

Quantification of MCT1 and CD147 in Red Blood Cells of Arabian and Quarter Horses

Regatieri

Almeida

Neto

et al. 2016

Journal of Equine Veterinary Science

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“…Lactate transport across the sarcolemma is mediated by protonlinked monocarboxylate transporters (MCT1 and MCT4) in mammalian skeletal muscle [4][5][6] . MCT1 facilitates the uptake of lactate into oxidative muscle fibers, whereas MCT4 facilitates the lactate efflux from glycolytic muscle fibers [7][8][9][10] . We have previously reported that acute exercise and training increase the expression of MCT1 and MCT4 proteins in Thoroughbred horses 11,12) .…”

Section: Introductionmentioning

confidence: 99%

Muscle glycogen breakdown and lactate metabolism during intensive exercise in Thoroughbred horses

Kitaoka

Endo

Mukai

et al. 2014

JPFSM

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We examined the muscle glycogen, and muscle and plasma lactate concentrations before and after 1 and 2 min of intensive exercise at 120% V ・ O 2 max, and examined possible relationships between these indexes and protein levels of monocarboxylate transporters (MCT) in the gluteus medius muscle of Thoroughbred horses. The horses underwent 1 and 2 min of intensive exercise at the speed of 120% maximal oxygen consumption (V ・ O 2 max) on a treadmill. The plasma lactate concentration increased after 1-min exercise (11.7 ± 0.8 mmol/L) and 2-min exercise (23.1 ± 1.1 mmol/L). The muscle lactate concentration increased after 1-min exercise (17.3 ± 2.1 mmol/kg) and 2-min exercise (23.6 ± 2.0 mmol/kg). While there was no significant difference in lactate accumulation in the plasma between the first minute and the second minute, lactate accumulation in muscle significantly decreased in the second minute compared with the first minute. The muscle glycogen level decreased after both 1-(42%) and 2-min (41%) exercise, but there was no difference between the levels after 1-and 2-min exercise. The muscle lactate concentration after 2-min intensive exercise positively correlated with the protein level of MCT4 (r = 0.78, p < 0.01). These results suggest that glycogen breakdown occurs in the first minute of intensive exercise, and Thoroughbred horses with higher muscle lactate production during exercise are endowed with higher expression of MCT4, that facilitates the efflux of lactate from muscle cells.

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Do sex-related differences and time of intervals affect the skeletal muscle glycolytic response to high-intensity interval exercise?‏

et al. 2020

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Regulation of the exercise-induced expression of the monocarboxylate transporters MCT1 and MCT4 in skeletal muscle

Cited by 6 publications

References 68 publications

Quantification of MCT1 and CD147 in Red Blood Cells of Arabian and Quarter Horses

Quantification of MCT1 and CD147 in Red Blood Cells of Arabian and Quarter Horses

Muscle glycogen breakdown and lactate metabolism during intensive exercise in Thoroughbred horses

Do sex-related differences and time of intervals affect the skeletal muscle glycolytic response to high-intensity interval exercise?‏

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