Abstract:C-terminal regions of the protein phosphatases PP1 and PP2B were seldom studied. C-terminal 24 amino acids of PP1 was deleted, its enzymatic activity increased 3-fold while its stability declined. When the truncated PP1 was fused with the terminal (residues 483-511) of PP2B, both its enzymatic activity and its stability remained low. This indicates that the termini of PP2B and PP1 have inhibitory effect on the catalytic domain of PP1. PP1-(1-306) and PP1wt differ in their activation by metal ions, showing that… Show more
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