Regulation of the Antibody Response to Type Iii Pneumococcal Polysaccharide

Baker, Phillip J.; Reed, Norman D.; Stashak, Philip W.; Amsbaugh, Diana F.; Prescott, Benjamin

doi:10.1084/jem.137.6.1431

Cited by 130 publications

(67 citation statements)

References 24 publications

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“…Consequently, the antibody response to this antigen is considered to be largely a B<ell response in which the antibody produced is predominantly of the IgM class (22,24). Furthermore, the avidity of antibody specific for SSS-III remains essentially consistent over a 10,000-fold range of immunizing doses and after reimmunization with low or high doses of antigen, indicating the lack of an antigen-mediated cell selection process (26).…”

Section: Discussionmentioning

confidence: 99%

“…Cooperation between "helper" T cells and bone marrow-derived precursors of antibody-forming cells (B cells) has not been found to be required for an antibody response to SSS-III, a linear polymer composed of identical epitopes (20)(21)(22)(23)(24)(25). Consequently, the antibody response to this antigen is considered to be largely a B<ell response in which the antibody produced is predominantly of the IgM class (22,24).…”

Section: Discussionmentioning

confidence: 99%

“…In this context, the existence of two functionally distinct types of thymus-derived cells (amplifier and suppressor T cells), that act in either a positive or a negative manner to influence the magnitude of the antibody response to SSS-III (24,(30)(31)(32)(33)(34), implies that these activities may be under separate genetic control and could act independently to regulate the number of antibody-forming cells obtained after immunization and the amount of antibody synthesized by such cells (1).…”

Section: Genetic Controlmentioning

confidence: 99%

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Genetic Control of the Antibody Response to Type Iii Pneumococcal Polysaccharide in Mice

Amsbaugh

Hansen

Prescott

et al. 1974

The Journal of Experimental Medicine

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Serum IgM immunoglobulin levels and antibody responses to an optimally immunogenic dose of Type III pneumococcal polysaccharide (SSS-III) were assessed for F1, F2, and backcross progeny derived from crosses between high responding BALB/cAnN (B) and low responding CBA/HN (C) mice. The results obtained confirmed our original hypothesis, namely, that a major component, present on the X chromosome, governs the ability to respond to SSS-III in a decisive manner. Although all low responding C mice had low IgM levels, both intermediate and high responders had high IgM levels of the same magnitude. Treatment with bacterial lipopolysaccharides (LPS) resulted in a significant increase in the IgM levels of low responding C mice. While the IgM levels attained were similar to those of high responding B mice, not given LPS, no antibody specific for LPS appeared to be produced. These findings suggest that C mice are unable to make an IgM antibody response to SSS-III and other polysaccharide antigens, despite the fact that they possess the capacity to synthesize normal amounts of IgM immunoglobulin.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Genetic Controlmentioning

confidence: 99%

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Genetic Control of the Antibody Response to Type Iii Pneumococcal Polysaccharide in Mice

Amsbaugh

Hansen

Prescott

et al. 1974

The Journal of Experimental Medicine

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“…In the present study, evidence is presented to indicate that antigen-driven expression of H-chain classes occurs during the antibody response to SSS-III (type III pneumococcal polysaceharide), an antigen that is helper T-cell independent (16,17). When two different methods were used for the detection of class-specific yl, y2, and yA PFC, we found that a large percentage (>50) of yM PFC are also detected as 3'1, y2, or yA PFC and that those PFC populations most likely "switch" to exclusively yG-or yA-seereting PFC.…”

Section: (4)mentioning

confidence: 99%

Synthesis of two classes of antibody, gammaM and gammaG or gammaM and gammaA, by identical cells. Amplification of the antibody response to pneumococcal polysaccharide type III.

Pasanen¹,

Asofsky²,

Baker³

1979

The Journal of Experimental Medicine

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Class-specific plaque-forming cell (PFC) (gammaM, gamma1, gamma2, and gammaA) responses to type III pneumococcal polysaccharide (SSS-III) were studied in BALB/c x C57BL/6F1 (CBF1) mice with and without induction of an allogeneic effect. Gamma1, gamma2, and gammaA PFC were detected in two ways: (a) With the sequential development of the assay slides, first for direct (gammaM)PFC followed by incubation with class-specific antiimmunoglobulin and complement for the development of additional gamma1, gamma2, and gammaA PFC (gammaM-independent gamma1, gamma2, and gammaA PFC); and (b) by blocking gammaM PFC with goat anti-gammaM and simultaneously developing gamma1, gamma2, and gammaA PFC (total gamma1-, gamma2-, and gammaA-secreting PFC). The results showed that whereas gammaM PFC arose on the 3rd d after immunization, gamma1-, gamma2-, and gammaA-secreting PFC arose on the 4th to 5th d after immunization. They appeared in association with gammaM-secreting PFC because they were detected with the gammaM blocking method but not with the sequential method. By the 7th d most gamma1, gamma2, and gammaA PFC were detected by the sequential method as well, indicating that those antibodies were secreted independently of cells secreting gammaM. When the numbers of double-class-secreting PFC were evaluated on the 5th d, the following results were obtained: 83% of gammaM PFC were secreting either gamma1 (25%), gamma2 (55%), or gammaA (2%). We interpret these data as evidence for an antigen-driven class differentiation from gammaM to gammaA and from gammaM to gammaG in the majority of anti-SSS-III-secreting clones without T-cell help. When an allogeneic effect was provided by inoculation of parental BALB/c spleen cells together with antigen, the numbers of all classes of PFC were increased. Furthermore, the frequency of gammaM-gammaG (108%) or gammaM-gammaA (9%) double-class secretors was increased, and gammaM-independent gammaG and gammaA secretors were detected earlier, indicating an overall maturation-promoting effect. In addition, prolonged appearance of gammaA PFC was dependent on the allogeneic effect.

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“…Examples of thymus-independent antigens include pneumococcal polysaccharide (Manning et al, 1972;Baker et al, 1973), polyvinylpyrrolidone (PVP; Kerbel & Eidinger, 1971;Rotter & Trainin, 1974), and bacterial lipopolysaccharide (LPS; Moller & Michael, 1971;Manning et al, 1972). Although they may be helper T cellindependent, other regulatory T cells may control antibody response to these antigens (Baker et al, 1973(Baker et al, , 1974aBarthold et al, 1974;Rotter& Trainin, 1974 There are also T suppressor cells that regulate T cell responses such as those involved in the induction of specific tolerance to contact sensitivity to 2,4-dinitrofluorobenzene (DNFB) (Phanuphak et al, 1974;Moorhead, 1976). In our previous study we found that the tolerance induced to DNFB contact sensitization was enhanced during dengue virus infection .…”

Section: Introductionmentioning

confidence: 99%

Effect of Experimental Dengue Virus Infection on Immune Response of the Host. I. Nature of Changes in T Suppressor Cell Activity Regulating the B and T Cell Responses to Heterologous Antigens

Nagarkatti

1983

Journal of General Virology

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SUMMARYDengue virus-infected mice showed a depressed antibody response to polyvinylpyrrolidone (PVP) when compared to controls. In both control and dengue virus-infected animals which were treated with anti-thymocyte serum (ATS) and primed with PVP, there was a heightened antibody response to PVP, suggesting that the anti-PVP response was controlled by T suppressor cells. The increase in the anti-PVP response in dengue virus-infected, ATS-treated animals was found to be similar to that seen in ATS-treated controls. T cells from infected animals could transfer suppression of anti-PVP response to normal mice, whereas the T cells from control animals could not induce significant suppression. The T cells from dengue virus-infected animals which had received 2,4-dinitrofluorobenzene (DNFB) tolerogen could induce in normal mice a significantly higher percentage of tolerance to contact sensitivity to DNFB when compared to the control T cells. The adherent and B cells from both infected and control animals failed to induce significant tolerance. These findings suggested that during dengue virus infection, there is enhanced T suppressor cell activity regulating the B cell response to PVP and T cell response to DNFB.

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Regulation of the Antibody Response to Type Iii Pneumococcal Polysaccharide

Cited by 130 publications

References 24 publications

Genetic Control of the Antibody Response to Type Iii Pneumococcal Polysaccharide in Mice

Genetic Control of the Antibody Response to Type Iii Pneumococcal Polysaccharide in Mice

Synthesis of two classes of antibody, gammaM and gammaG or gammaM and gammaA, by identical cells. Amplification of the antibody response to pneumococcal polysaccharide type III.

Effect of Experimental Dengue Virus Infection on Immune Response of the Host. I. Nature of Changes in T Suppressor Cell Activity Regulating the B and T Cell Responses to Heterologous Antigens

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