Effect of Experimental Dengue Virus Infection on Immune Response of the Host. I. Nature of Changes in T Suppressor Cell Activity Regulating the B and T Cell Responses to Heterologous Antigens

Abstract

SUMMARYDengue virus-infected mice showed a depressed antibody response to polyvinylpyrrolidone (PVP) when compared to controls. In both control and dengue virus-infected animals which were treated with anti-thymocyte serum (ATS) and primed with PVP, there was a heightened antibody response to PVP, suggesting that the anti-PVP response was controlled by T suppressor cells. The increase in the anti-PVP response in dengue virus-infected, ATS-treated animals was found to be similar to that seen in ATS-treated controls. T cells from infected animals could transfer suppression of anti-PVP response to normal mice, whereas the T cells from control animals could not induce significant suppression. The T cells from dengue virus-infected animals which had received 2,4-dinitrofluorobenzene (DNFB) tolerogen could induce in normal mice a significantly higher percentage of tolerance to contact sensitivity to DNFB when compared to the control T cells. The adherent and B cells from both infected and control animals failed to induce significant tolerance. These findings suggested that during dengue virus infection, there is enhanced T suppressor cell activity regulating the B cell response to PVP and T cell response to DNFB.

Pathobiology of the Flaviviruses

“…The cells responsible for suppression had both Ly-l + and Ly-2 + markers. P. S. Nagarkatti and M. Nagarkatti (1983) have also demonstrated enhanced T-suppressor-cell activity in dengue-virus-infected mice, regulating both T-and B-cell responses and adoptively transferable to normal mice.…”

Dengue and dengue haemorrhagic fever: Indian perspective

“…On the other hand, suppression of neutralizing antibody would delay elimination of DV from the body causing pathological lesions (Chaturvedi et al 1984. Suppressor T cell activity, regulating B and T cell response in dengue type 3 virus-infected mice has been shown (Nagarkatti and Nagarkatti 1983).…”

Denguevirus-specific suppressor T cells: current perspectives

“…Suppressor T-cell activity, regulating B-and T-cell responses in dengue type 3 virus-infected mice has been shown (Nagarkatti & Nagarkatti, 1983). Induction of suppressor cells in DV may suppress the cell-mediated immune response and thus protect the body against T-cell-mediated damage.…”