Regulation of skeletal muscle transcriptome in elderly men after 6 weeks of endurance training at lactate threshold intensity

Effects of home-based bench step exercise on inflammatory cytokines and lipid profiles in elderly Japanese females: A randomized controlled trial

“…It should be noted that although HMW-APN was included in the current PCA, other important anti-inflammatory cytokines such as IL-10 and IL-1ra were not evaluated in the present study, and these two representative anti-inflammatory cytokines were not used to calculate the abovementioned PCAderived factors. As mentioned in the introduction, a moderate exercise regimen can enhance the HDL-C levels (Kumagai et al, 1994;Motoyama et al, 1995;Riedl et al, 2010;Sasaki et al, 1989;Sunami et al, 1999;Urata et al, 1987), while systemic inflammation is known to suppress the HDL-C levels (Hardardottir et al, 1994). It has also been reported that exercise training/ physical activity are able to modulate the circulating levels of not only frequently measured cytokines such as IL-6 and TNF-a, but also other less frequently investigated cytokines such as IL-4, IL-8, and IL-15 (Balducci et al, 2010;Nishida et al, 2014;Palmefors et al, 2014).…”

“…Moderate exercise at the lactate threshold (LT) has been well documented to be an optimal exercise regimen that can safely increase aerobic fitness and improve HDL-C levels in elderly or patients (Kumagai, Shono, Kondo, & Nishizumi, 1994;Motoyama et al, 1995;Riedl et al, 2010;Sasaki et al, 1989;Sunami et al, 1999;Urata et al, 1987). Older subjects have a high level of compliance with good adherence to our home-based bench step exercise program (Mori et al, 2011;Ohta et al, 2012), since these exercises performed at the individually determined LT are not hard for the elderly, and are easily performed on a daily basis at home whenever they want, using a bench step (bench height 15-20 cm) and a compact disc that provides a regular rhythm set at the individual's LT (Ayabe et al, 2003).…”

ATP Citrate Lyase Improves Mitochondrial Function in Skeletal Muscle

“…Anabolic stimuli like exercise have a positive impact on skeletal muscle strength, endurance, and aerobic capacity by increasing protein synthesis, in addition to mitochondrial and contractile function of skeletal muscle (Egan and Zierath, 2013;Egerman and Glass, 2014;Riedl et al, 2010). The positive effects of exercise extend to diseased populations and to the elderly (Fiatarone et al, 1990;Hansen et al, 2010;Jeppesen et al, 2006).…”

Differential Effects of Aerobic Exercise, Resistance Training and Combined Exercise Modalities on Cholesterol and the Lipid Profile: Review, Synthesis and Recommendations

“…The mechanisms may include increases in lecithin-cholesterol acyltrans (LCAT)—the enzyme responsible for ester transfer to HDL cholesterol [19], which has been shown to increase following exercise training [20]—and increases in lipoprotein lipase activity, although the data in this instance are inconsistent [21] and may depend upon the energy expenditure that is elicited. Ferguson et al.…”