Regulation of renal organic anion and cation transporters by thymoquinone in cisplatin induced kidney injury

Ulu, Ramazan; Doğukan, Ayhan; Tuzcu, Mehmet; Gençoğlu, Hasan; Ulaş, Mustafa; İlhan, Nevin; Muqbil, Irfana; Mohammad, Ramzi M.; Küçük, Ömer; Şahin, Kazım

doi:10.1016/j.fct.2012.02.082

Cited by 63 publications

(40 citation statements)

References 31 publications

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“…In contrast, our data suggest that Oat1 protein expression is not changed, although levels tend to decrease in the ob/ob and db/db models. This is in contrast to studies that suggest Oat1 and Oat3 are commonly coordinated together by various stressors and exogenous stressors (Jin et al, 2012;Ulu et al, 2012;Guo et al, 2013). However, consistent with our results, similar findings have been reported in experimental models of cholestasis.…”

Section: Tubular Degenerationcontrasting

confidence: 57%

Renal Xenobiotic Transporter Expression is Altered in Multiple Experimental Models of Nonalcoholic Steatohepatitis

et al. 2014

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Nonalcoholic fatty liver disease is the most common chronic liver disease, which can progress to nonalcoholic steatohepatitis (NASH). Previous investigations demonstrated alterations in the expression and activity of hepatic drug transporters in NASH. Moreover, studies using rodent models of cholestasis suggest that compensatory changes in kidney transporter expression occur to facilitate renal excretion during states of hepatic stress; however, little information is currently known regarding extrahepatic regulation of drug transporters in NASH. The purpose of the current study was to investigate the possibility of renal drug transporter regulation in NASH across multiple experimental rodent models. Both rat and mouse NASH models were used in this investigation and include: the methionine and choline-deficient (MCD) diet, atherogenic diet, fa/fa rat, ob/ob and db/db mice. Histologic and pathologic evaluations confirmed that the MCD and atherogenic rats as well as the ob/ob and db/db mice all developed NASH. In contrast, the fa/fa rats did not develop NASH but did develop extensive renal injury compared with the other models. Renal mRNA and protein analyses of xenobiotic transporters suggest that compensatory changes occur in NASH to favor increased xenobiotic secretion. Specifically, both apical efflux and basolateral uptake transporters are induced, whereas apical uptake transporter expression is repressed. These results suggest that NASH may alter the expression and potentially function of renal drug transporters, thereby impacting drug elimination mechanisms in the kidney.

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Section: Tubular Degenerationcontrasting

confidence: 57%

Renal Xenobiotic Transporter Expression is Altered in Multiple Experimental Models of Nonalcoholic Steatohepatitis

et al. 2014

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“…35 Ulu et al have shown in their study that TQ has a protective effect on renal tissue in rats with acute kidney injury induced by cisplatin. 36 These results make us consider that TQ removes/eliminates the oxy-radicals/ROS in the environment and therefore prevents the oxidation of the lipids.…”

Section: Discussionmentioning

confidence: 99%

Protective effects of thymoquinone against apoptosis and oxidative stress by arsenic in rat kidney

et al. 2015

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We aimed to investigate the protective role of thymoquinone (TQ) by targeting its antiapoptotic and antioxidant properties against kidney damage induced by arsenic in rats. We have used the 24 male Sprague-Dawley rats. Rats were divided into three groups. Physiological serum in 10 mL/kg dose as intragastric was given to the control group. Sodium arsenite (10 mg/kg, intragastric by gavage for fifteen days) was given to the arsenic group. Sodium arsenite (10 mg/kg, intragastric by gavage for fifteen days) and TQ (10 mg/kg, intragastric by gavage for 15 days) was given to the arsenic + TQ group. After 15 days, the animals' kidneys were taken theirs, then we have performed histological and apoptotic assessment. Superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) enzyme activities and malondialdehyde (MDA) levels have examined as the oxidative stress parameters. We have determined the levels of arsenic. Increased renal injury and apoptotic cells have been detected in the arsenic group. Degenerative changes in the arsenic + TQ group were diminished. Although the MDA levels were augmented in the arsenic group, SOD, CAT and GSH-Px enzyme activities were lessened than the other groups. Our findings suggest that TQ may impede the oxidative stress, the cells have been damaged and also the generation of apoptotic cells arisen from arsenic. TQ plays a protective role against arsenic-induced toxicity in kidney and may potentially be used as a remedial agent.

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“…Conversely, TQ treatment increased levels of OCT1, OCT2, OAT1 and OAT3 and decreased levels of 8-isoprostane and MDA levels in cisplatin-treated rats. This is concluded that TQ synergizes with its nephroprotective effect against cisplatin-induced acute kidney injury in rats [89] . The protective effects of N. sativa oil on methotrexate-induced nephrotoxicity were also studied in albino rats and this study revealed the protective effect of Black cumin in the methotrexate-induced nephrotoxcity [90] .…”

Section: Nephroprotective Activitymentioning

confidence: 97%

A review on therapeutic potential of Nigella sativa: A miracle herb

Ahmad

Husain

Mujeeb

et al. 2013

Asian Pacific Journal of Tropical Biomedicine

1,023

796

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Regulation of renal organic anion and cation transporters by thymoquinone in cisplatin induced kidney injury

Cited by 63 publications

References 31 publications

Renal Xenobiotic Transporter Expression is Altered in Multiple Experimental Models of Nonalcoholic Steatohepatitis

Renal Xenobiotic Transporter Expression is Altered in Multiple Experimental Models of Nonalcoholic Steatohepatitis

Protective effects of thymoquinone against apoptosis and oxidative stress by arsenic in rat kidney

A review on therapeutic potential of Nigella sativa: A miracle herb

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