Regulation of Prolactin Gene Expression by Vasoactive Intestinal Peptide and Dopamine in the Turkey: Role of Ca2+ Signalling

Kahtane, A Al; Kannan, Mathur; Kang, Seong Wook; Halawani, M. E. El

doi:10.1111/j.1365-2826.2005.01352.x

Cited by 13 publications

(6 citation statements)

References 42 publications

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“…PRL plays an important role in the maintenance of broodiness in geese (Usman et al, 2014). Moreover, VIP is secreted by the hypothalamus and stimulates PRL expression and release in vivo and in vitro (Kuenzel, 2003;Al Kahtane et al, 2005). Our results indicate that serum VIP concentrations were significantly lower in Sichuan white geese during the laying period at 32, 45, and 58 weeks compared with Xupu geese (P < 0.01) ( Figure 2G).…”

Section: Discussionmentioning

confidence: 65%

Effect of photoperiod on serum hormone concentrations during the annual reproductive cycle in geese

et al. 2017

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ABSTRACT. The poor egg-laying rate of geese hinders the development of the goose industry; therefore, the reproductive performance of geese is an important area of investigation. To evaluate the relationship between photoperiod, reproductive hormones, and reproductive activity during the egg-laying cycle in geese under natural conditions, we collected blood samples from Sichuan white geese and Xupu geese to quantify changes in prolactin (PRL), estradiol (E2), vasoactive intestinal polypeptide (VIP), follicle stimulating hormone (FSH), gonadotropin-inhibitory hormone (GnIH), and luteinizing hormone (LH). We also calculated the rate of egg laying for the two populations during the egg-laying cycle. We show that the egg-laying rate and the serum concentration of some hormones (PRL, E2, VIP, FSH, GnIH, and LH) differed significantly between the two populations during the pre-laying, laying, and ceased-laying periods. Serum LH concentrations may be associated with maturation of the 2 X.Z. Zhao et al.Genetics and Molecular Research 16 (1): gmr16019266 ovary and oviducts, whereas FSH, PRL, and GnIH play important roles in egg laying. These results provide a useful resource for future studies examining the laying rate in geese.

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Section: Discussionmentioning

confidence: 65%

Effect of photoperiod on serum hormone concentrations during the annual reproductive cycle in geese

et al. 2017

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“…The dual role of DA in PRL secretion and gene expression, stimulating via D 1 DA receptors and inhibiting via D 2 DA receptors is well established (3–7). Tonic stimulation of PRL secretion and gene expression are regulated centrally via D 1 DA receptors on VIP neurones (3, 4), whereas PRL secretion and gene expression are inhibited at the level of the anterior pituitary by blocking the action of VIP via D 2 DA receptors (5–7). The role of DA in gonadotrophin regulation remains controversial because both stimulatory and inhibitory effects have been reported (8).…”

mentioning

confidence: 99%

Identification of Dopamine, Gonadotrophin‐Releasing Hormone‐I, and Vasoactive Intestinal Peptide Neurones Activated by Electrical Stimulation to the Medial Preoptic Area of the Turkey Hypothalamus: A Potential Reproductive Neuroendocrine Circuit

Al-Zailaie

Kang

Youngren

et al. 2006

J Neuroendocrinology

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The neural and neurochemical substrates regulating reproduction in birds remain vaguely defined. The findings that electrical stimulation in the medial preoptic area (ES/MPOA) or intracerebroventricular infusion of dopamine (DA) stimulated luteinising hormone (LH) and prolactin (PRL) release in female turkeys, led to the suggestion that ES/MPOA might help to clarify the DA circuitry regulating LH and PRL. We used c-fos mRNA and tyrosine hydroxylase immunoreactivity as measured by double in situ hybridisation/immunocytochemistry (ISH/ICC) to determine which group/subgroup of DA neurones was activated following unilateral ES/MPOA. To establish that the reproductive neuroendocrine system was activated, double ISH/ICC was also conducted on c-fos/gonadotrophin-releasing hormone-I (GnRH-I) and c-fos/vasoactive intestinal peptide (VIP). Changes in circulating LH and PRL were determined by radioimmunoassay. Unilateral ES/MPOA (100 microA, right side) of anaesthetised laying turkeys for 30 min increased circulating LH and PRL levels. It also induced c-fos mRNA expression on the ipsilateral side by all GnRH-I neurones within the septopreoptic region, implying that GnRH-I neurones in this region share similar circuitry. VIP neurones within the nucleus infundibularis were the only VIP group to show c-fos mRNA expression, suggesting their involvement in ES/MPOA induced PRL release. c-fos mRNA expression was also observed in a subgroup of DA neurones in the nucleus mamillaris lateralis (ML). To our knowledge, the present study is the first to show that activation of DAergic cells in the ML is associated with the activation of GnRH-I and VIP neurones and the release of LH and PRL. It is likely that ES/MPOA activated VIP/GnRH-I neurones via activation of DA neurones in the ML, as this was the only DA subgroup that showed c-fos mRNA expression.

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“…Prolactin secretion in birds is predominantly regulated by releasing factors of which the best characterized are vasoactive intestinal peptide (VIP), dopamine (DA) and serotonine (5-HT) (KAGYA-AGYEMANG et al 2012). Prolactin (PRL) secretion in avian species is under tonic stimulatory control exerted by the hypothalamus (DAVID et al 2003;AL KAHTANE et al 2005). In birds, the hypothalamus actively secretes one or more prolactin releasing factors (PRF) and the presence of a prolactin inhibiting factor (PIF) has been described (SILVER & SALDANHA 1993).…”

Section: Prl Gene and Prolactinmentioning

confidence: 99%

“…Several lines of evidence indicate that VIP is the PRLreleasing factor (PRF) in birds (OPEL & PROUDMAN 1988). In addition, VIP stimulates prolactin release and expression in vivo and in vitro in several avian species (AL KAHTANE et al 2005). The results of research conducted by Prolactin (PRL) AL KAHTANE et al (2003) show that VIP treatment increased PRL release into the medium about 20-to 30-fold in comparison with that of untreated pituitary cells.…”

Section: Prl Gene and Prolactinmentioning

confidence: 99%

Prolactin (PRL) and Prolactin Receptor (PRLR) Genes and their Role in Poultry Production Traits

Wilkanowska¹,

Mazurowski²,

Mroczkowski³

et al. 2014

folia biol (krakow)

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Prolactin (PRL), secreted from the anterior pituitary, plays extensive roles in osmoregulation, corpus luteum formation, mammogenesis, lactogenesis, lactopoiesis, and production of crop milk. In birds, prolactin (PRL) is generally accepted as crucial to the onset and maintenance of broodiness. All the actions of prolactin (PRL) hormone are mediated by its receptor (PRLR), which plays an important role in the PRL signal transduction cascade. It has been well established that the PRL gene is closely associated to the onset and maintenance of broody behavior, and could be a genetic marker in breeding against broodiness in chickens. Meanwhile, the prolactin receptor (PRLR) gene is regarded as a candidate genetic marker for reproductive traits. PRLR is also an important regulator gene for cell growth and differentiation. The identified polymorphism of this gene is mainly viewed in terms of egg production traits. Due to different biological activities attributed to PRL and PRLR, they can be used as major candidate genes in molecular animal breeding programs. Characterization of PRL and PRLR genes helps to elucidate their roles in birds and provides insights into the regulatory mechanisms of PRL and PRLR expression conserved in birds and mammals.

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Regulation of Prolactin Gene Expression by Vasoactive Intestinal Peptide and Dopamine in the Turkey: Role of Ca²⁺ Signalling

Cited by 13 publications

References 42 publications

Effect of photoperiod on serum hormone concentrations during the annual reproductive cycle in geese

Effect of photoperiod on serum hormone concentrations during the annual reproductive cycle in geese

Identification of Dopamine, Gonadotrophin‐Releasing Hormone‐I, and Vasoactive Intestinal Peptide Neurones Activated by Electrical Stimulation to the Medial Preoptic Area of the Turkey Hypothalamus: A Potential Reproductive Neuroendocrine Circuit

Prolactin (<I>PRL</I>) and Prolactin Receptor (<I>PRLR</I>) Genes and their Role in Poultry Production Traits

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