Prolactin (&lt;I&gt;PRL&lt;/I&gt;) and Prolactin Receptor (&lt;I&gt;PRLR&lt;/I&gt;) Genes and their Role in Poultry Production Traits

Wilkanowska, Anna; Mazurowski, Artur; Mroczkowski, S.; Kokoszyński, Dariusz

doi:10.3409/fb62_1.1

Cited by 53 publications

(40 citation statements)

References 65 publications

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“…PRL is one of the strongest decidualization markers [129] involved in regulating endometrial secretory activity in human and rodent, but not in canine [130]. However, it is noteworthy that PRL cannot play important role in the signal transduction cascade without its receptor, PRLR [131]. In this study, the miR-182 mimics did not regulate the protein levels of PRLR in the EECs of dairy goats, but the miR-182 inhibitors down-regulated the levels, suggesting that miR-182 may be an essential factor to keep the expression of PRLR protein levels in the EECs of dairy goats.…”

Section: Discussionmentioning

confidence: 99%

miR-182 aids in receptive endometrium development in dairy goats by down-regulating PTN expression

Zhang

Liu

et al. 2017

PLoS ONE

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Increasing evidence has shown that miRNAs play important roles in endometrium development during the menstrual cycle in humans and many other animals. Our previous data indicated that miR-182 levels increase 15.55-fold and pleiotrophin (PTN) levels decrease 20.97-fold in the receptive endometrium (RE, D15) compared with the pre-receptive endometrium (PE, D5) in dairy goats. The present study shows that miR-182 is widely expressed in different tissues of dairy goats and that its expression levels are regulated by E2 and P4 in endometrial epithelium cells (EECs). We confirmed that PTN is a target of miR-182 and that miR-182 regulates the protein levels of AKT, Bcl-2, FAS, MAPK, Caspase-3 and SP1 in EECs. Furthermore, miR-182 up-regulates or maintains the expression levels of osteopontin (OPN), cyclooxygenase-2 (COX-2) and prolactin receptor (PRLR) in EECs, suggesting that miR-182 is an important regulatory factor in the construction of endometrial receptivity in dairy goats. In conclusion, miR-182 participates in the development of endometrial receptivity by down-regulating PTN and affecting the expression of select apoptosis-related genes and increasing or maintaining the expression levels of OPN, COX-2 and PRLR in the EECs of dairy goats.

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Section: Discussionmentioning

confidence: 99%

miR-182 aids in receptive endometrium development in dairy goats by down-regulating PTN expression

Zhang

Liu

et al. 2017

PLoS ONE

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“…Pituitary VIP stimulated prolactin release and expression in vivo and in vitro in several avian species (Al Kahtane et al, 2005). VIP promoted the release of PRL in different period and then maintained broodiness in chicken Wilkanowska et al, 2014). Immunisation against VIP antibody in bantam hens during broodiness resulted in the termination of nesting within 5 days and the serum PRL level significantly declined (Sharp et al, 1989;March and Sharp, 1994).…”

Section: Discussionmentioning

confidence: 96%

Prokaryotic Expression and Active Immunisation against Recombinant-Derived Prolactin Fusion Protein on Broodiness and Egg-Laying in Wanxi-White Goose

Chen

Wang

et al. 2015

Avian Biology Research

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This experiment aims to produce a recombinant prolactin (rPRL) for use in immunising Wanxi-white goose and to determine the immunisation effects on broodiness and egg production. A stable prokaryotic expression system with rPRL obtained extra-cellularly was established. Wanxi-white geese (n = 100) performed broodiness were randomly divided into five groups (20 per group): group I was injected with saline as negative control, group II was orally administered with Bromocriptine as positive control, groups III, IV and V were subcutaneously injected with either 1, 2 or 4 mg·mL -1 rPRL, respectively. This process (FA-I) was repeated after interval of 10 days (SA-I). After FA-I, broodiness significantly decreased in groups III, IV and V compared to group I (P < 0.01), while egg production showed no significant difference among groups. After SA-I, broodiness in group IV and V was significantly lower than that of other groups (P < 0.05), and egg production percentage in group IV showed significantly higher than that of group III (P <0.05), but only numerically higher than that of other groups. Broodiness showed no difference among groups 10 days after SA-I, but broodiness was significantly increased to more than 20% in all groups. Serum prolactin concentrations showed high secretion in geese under broodiness and decreased in geese that wake up from broodiness after SA-I. In conclusion, active immunisation with rPRL decreased broodiness and increased egg production in Wanxi-white geese. However, the immune period was short, and the performance was significantly affected by environmental factors.

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“…The gene encoding follistatin (FST), which inhibits follicle-stimulating hormone (FSH) (Depaolo et al, 1991;Robertson et al, 1990;Wang et al, 1990;Ying et al, 1987) and therefore affects reproduction, was expressed higher in RJF. TSHB and DIO2 stimulate metabolism and reproduction (Nakao et al, 2008), whereas PRLR, MTNR1B and PGR modulate seasonal behavior, including reproduction, molting and broodiness (Wilkanowska et al, 2014), and these genes were all expressed higher in WL.…”

Section: The Pituitary Gland As a Regulator Of Domestication-related mentioning

confidence: 99%

Domestication and early experiences in chickens: Behavior, stress and gene expression

Løtvedt¹

2017

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A number of animal species have undergone domestication, the process of becoming adapted to living in captivity and in proximity to humans. Common for these species is that they have all developed certain traits, including changes to coat color, body size and level of fearfulness. This has been termed the domestic phenotype. Among these traits is also an attenuation of the response to stress, both behaviorally and physiologically. Thus, release of glucocorticoids such as cortisol or corticosterone is lower in domesticated species. However, the underlying mechanism for this is not yet well understood. In this thesis, we have investigated genetic mechanisms for the attenuation of the physiological stress response in ancestral chickens, the Red Junglefowl, and domesticated chickens, the White Leghorn.We found a number of genes that differed in expression between the two breeds in several tissues involved in the stress response. Among the most interesting findings were lower expression of genes involved in production and secretion of ACTH in the pituitary, and in the production of glucocorticoids in the adrenal glands, in the domesticated White Leghorns. We also found higher expression of the glucocorticoid receptor in White Leghorns, indicating that they may have a more efficient negative feedback of the physiological stress response.We then investigated the transcriptome of the chicken pituitary more closely, and we discovered that a number of genes highly involved in several important physiological axes showed differential expression between the ancestral and the domesticated breed. Among these were genes involved in the stress response, the reproductive system, and in metabolism and growth. As these traits are modified in domesticated species, our results suggest that changes to gene expression in the pituitary may be an important underlying factor of the domestic phenotype.A separate aim of this thesis was to investigate effects of hatching time in chickens on their subsequent phenotype. Time of hatching constitutes an early experience that may differ between individuals, and we therefore hypothesized that differences in hatching time would affect chickens later in life. While a number of studies have been performed on hatching time and post-hatch growth, very little work has been done on effects on behavior. We found that the time of hatching had sex-specific effects. Hatching times in females were negatively correlated with body weight, whereas in males, behaviors such as reaction to novelty and spatial learning were affected.As time of hatching is governed by various hormones, including thyroid hormone and corticosterone, we suggest that changes to the levels of these hormones could affect both hatching time and post-hatch phenotypes. Understanding these mechanisms better would be beneficial in terms of production, where batch homogeneity is important, in research on early experiences and the potential for maternal programming, and in evolutionary questions on trade-off between different life strateg...

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Prolactin (<I>PRL</I>) and Prolactin Receptor (<I>PRLR</I>) Genes and their Role in Poultry Production Traits

Cited by 53 publications

References 65 publications

miR-182 aids in receptive endometrium development in dairy goats by down-regulating PTN expression

miR-182 aids in receptive endometrium development in dairy goats by down-regulating PTN expression

Prokaryotic Expression and Active Immunisation against Recombinant-Derived Prolactin Fusion Protein on Broodiness and Egg-Laying in Wanxi-White Goose

Domestication and early experiences in chickens: Behavior, stress and gene expression

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