Regulation of Pancreatic Exocrine Function by Manganese

Korc, Murray; Brannon, Patsy M.

doi:10.1007/978-1-4613-0723-5_15

Cited by 3 publications

(1 citation statement)

References 13 publications

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“…Although thereis no explanation for the increased pancreatic Zn at high Mn intakes, bothMn and Zn are involved in pancreatic endocrine function. Manganese is relatively enriched in the pancreas (Table 2), and although the mechanism underlying its action in this tissue is not well understood, Mn in known to regulate pancreatic exocrinefunction (Korc& Brannon 1988). Manyof the enzymes secreted containZn.…”

Section: Discussionmentioning

confidence: 99%

Effect of Co, Cu, Fe, Mn, Mo, Se, and Zn supplementation on the elemental content of soft tissues and bone in sheep grazing ryegrass/white clover pasture

Grace¹,

Lee²

1990

New Zealand Journal of Agricultural Research

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, and Mn (l05-455) on the concentrations of major and minor elements in some organs, soft tissues, and bones of 72 Romney wethers were measured. The treatment and two control groups were each made up of six sheep. Trace elements were administered daily for 84 days and the sheep grazed as one group on ryegrass/white clover pasture. The animals were then shorn and slaughtered, and some organs, tissue, and bones removed for elemental analyses. A 40% increase in liver Cu occurred when Cu intakes were increased. The Se contents of the liver, kidney, and plasma were increased by over 200% and wool by 23% with increased Se intake. Similarly, increased Mn intakes increased the Mn contents of the liver, kidney, spleen, brain, and pancreas by over 25% and the gut by 260%, and increased Fe intakes increased the Fe contents of the lungs, spleen, and gut by 30, 57, and 76% respectively. Iron also decreased the Cu contents in the carcass (27%) and, markedly, in the liver (45%). Bone mineral concentrations were influenced by increasing the intakes of Se, Mo, and Cu. The Mo and Se contents of the scapula, humerus, ulna/radius, and rib were increased by over 220 and 35% respectively with increased Mo and Se intakes, and the Ca, P, Mg and Na concentrations of the bone were elevated 16--23, 17-34, 19-27, and 8-18% respectively depending on the particular bone when supplementary Cu was given.

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Section: Discussionmentioning

confidence: 99%

Effect of Co, Cu, Fe, Mn, Mo, Se, and Zn supplementation on the elemental content of soft tissues and bone in sheep grazing ryegrass/white clover pasture

Grace¹,

Lee²

1990

New Zealand Journal of Agricultural Research

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Effects of Manganese Deficiency and Dietary Composition on Rat Pancreatic Enzyme Content

Werner¹,

Korc

Brannon³

1987

The Journal of Nutrition

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Recent studies show that manganese (Mn) deficiency increases pancreatic amylase content. Pancreatic adaptation to dietary composition also alters enzyme content. The present study investigated whether Mn deficiency alters pancreatic adaptation to diet. Weanling rats that were fed for 6 wk a high carbohydrate (HC) diet with less than 1 mg Mn/kg diet (Mn deficient) or 40 mg Mn/kg diet (control) were divided into three control and deficient dietary subgroups: 1) HC, 2) high protein (HP) or 3) high fat (HF). Rats were then fed these diets for 10 d. Body weights and food consumption were comparable among the groups. Pancreatic and hepatic Mn contents were significantly lower in Mn-deficient rats than in respective controls. Digestive enzymes adapted to diet in both control and Mn-deficient rats with the greatest amylase, lipase and trypsin activities in HC, HF and HP rats, respectively. Mn deficiency resulted in significantly greater amylase activity in HC and HP groups and lipase activity in only the HF group than in respective controls. These data suggest that Mn participates in the regulation of pancreatic amylase content and in the adaptive response of pancreatic lipase to dietary fat.

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