Regulation of NPY/NPY Y1 receptor/G protein system in rat brain cortex

Michel, Martin C.; Lewejohann, K.; Farke, W; Bischoff, Angela; Feth, Friedhelm; Rascher, Wolfgang

doi:10.1152/ajpregu.1995.268.1.r192

Cited by 13 publications

(18 citation statements)

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“…In our own studies we have previously reported Gprotein alterations in erythrocytes and platelets of adult HD and CAPD patients [8], but their regulation may depend on cell type rather than mode of dialysis. This is in good agreement with a large body of data indicating that within a given animal regulation of G-protein expression by, e.g., thyroid hormone [15] or arterial hypertension [9,10], also occurs in a tissue-dependent manner. In the present study a similar platelet expression of α-subunits of G i2 , G i3 , G s long and G s short was observed in HD and control children.…”

Section: Discussionsupporting

confidence: 91%

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Platelet adenylyl cyclase signaling remains unaltered in children undergoing hemodialysis treatment

Keffel

Bonzel

Wingen

et al. 2001

Pediatric Nephrology

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Patients with chronic renal failure exhibit multiple endocrine, gastrointestinal and cardiovascular abnormalities, many of which may be explained by alterations of adenylyl cyclase (AC) responsiveness and/or G-protein expression. Since such alterations were previously reported, e.g., for platelets of adult chronic renal failure patients undergoing hemodialysis treatment (HD), we have investigated whether children with chronic renal failure undergoing HD exhibit similar alterations. Eleven uremic children undergoing HD were compared with 11 age-matched healthy controls. Platelet AC activity was determined in the absence (basal) and presence of a receptor agonist, direct G-protein activators and direct AC stimulators. G-protein alpha-subunits were measured by quantitative immunoblotting. Basal and stimulated platelet AC and immunoreactivity for platelet G-protein alpha-subunits did not significantly differ between HD and control children. We conclude that HD in children is associated with much smaller, if any, abnormalities of blood cell signal transduction than in adult patients. We speculate that quality of dialysis, age, and underlying disease might differentially influence blood cell signal transduction cascades.

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Section: Discussionsupporting

confidence: 91%

“…All analyses were performed as recently described [9,10]. Briefly, blood samples were obtained prior to hemodialysis after 2 days without dialysis.…”

Section: Biochemical Analysesmentioning

confidence: 99%

Platelet adenylyl cyclase signaling remains unaltered in children undergoing hemodialysis treatment

Keffel

Bonzel

Wingen

et al. 2001

Pediatric Nephrology

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“…Sex-related differences in receptor affinity, expression and signal transduction may be responsible. Although the present study did not address receptor affinity per se, it is interesting that Y 1 receptors in female rat cerebral cortex show a greater affinity for NPY than Y 1 receptors in male rat cerebral cortex (Michel et al 1995).…”

Section: Discussionmentioning

confidence: 82%

Vascular responses to neuropeptide Y are greater in female than male rats

Glenn

Krause

Duckles

1996

Naunyn-Schmiedeberg's Arch Pharmacol

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Sex differences in vascular effects of neuropeptide Y (NPY) were investigated in isolated tail artery ring segments from male and female F344 rats. Both pre- and postjunctional effects of NPY appeared to be greater in females. NPY potentiated contractions elicited by transmural adrenergic nerve stimulation (TNS), consistent with an effect on smooth muscle Y1 receptors. The degree of potentiation was significantly greater in arteries from females than males. Ovariectomy of the females resulted in a decrease in potentiation, while orchiectomy of the males resulted in an enhanced NPY effect. When NPY potentiation was measured in the presence of peptidase inhibitors, the effect of exogenous NPY was enhanced; however the enhancement was greater in arteries from females than either males or ovariectomized females. Possible male-female differences in inhibitory prejunctional Y2 receptor function were addressed using the selective agonist NPY13-36. At a low frequency of stimulation (0.5 Hz), NPY13-36 inhibited the response to TNS in arteries from females and castrated males; however, NPY13-36 had no significant effect on responses to TNS in arteries from males or ovariectomized females. Thus gonadal hormones appear to modulate several components involved in NPY neurotransmission, including tissue peptidase activity, postjunctional Y1 and prejunctional Y2 receptors. These effects may contribute to significant differences observed in vascular reactivity between females and males.

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“…The complexity of sex-dependent differences in NPY-induced cardiovascular control is advanced by studies of cortical Y 1 R expression and sensitivity. Michel et al (75) examined the cerebral cortex of Wistar-Kyoto rats and SHR and noted that although the number of Y 1 R was similar between the breeds, females had half as many Y 1 R compared with males. However, binding affinity of these Y 1 R in females was twice that of males (75).…”

Section: Role Of Neuropeptide Y In the Regulation Of Vasomotor Tonementioning

confidence: 99%

Neuropeptide Y and neurovascular control in skeletal muscle and skin

Hodges

Jackson²,

Mattar³

et al. 2009

American Journal of Physiology-Regulatory, Integrative and Comp

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Neuropeptide Y (NPY) is a ubiquitous peptide with multiple effects on energy metabolism, reproduction, neurogenesis, and emotion. In addition, NPY is an important sympathetic neurotransmitter involved in neurovascular regulation. Although early studies suggested that the vasoactive effects of NPY were limited to periods of high stress, there is growing evidence for the involvement of NPY on baseline vasomotor tone and sympathetically evoked vasoconstriction in vivo in both skeletal muscle and the cutaneous circulation. In Sprague-Dawley rat skeletal muscle, Y(1)-receptor activation appears to play an important role in the regulation of basal vascular conductance, and this effect is similar in magnitude to the alpha(1)-receptor contribution. Furthermore, under baseline conditions, agonist and receptor-based mechanisms for Y(1)-receptor-dependent control of vascular conductance in skeletal muscle are greater in male than female rats. In skin, there is Y(1)-receptor-mediated vasoconstriction during whole body, but not local, cooling. As with the NPY system in muscle, this neural effect in skin differs between males and females and in addition, declines with aging. Intriguingly, skin vasodilation to local heating also requires NPY and is currently thought to be acting via a nitric oxide pathway. These studies are establishing further interest in the role of NPY as an important vasoactive agent in muscle and skin, adding to the complexity of neurovascular regulation in these tissues. In this review, we focus on the role of NPY on baseline vasomotor tone in skeletal muscle and skin and how NPY modulates vasomotor tone in response to stress, with the aim of compiling what is currently known, while highlighting some of the more pertinent questions yet to be answered.

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Regulation of NPY/NPY Y1 receptor/G protein system in rat brain cortex

Cited by 13 publications

References 0 publications

Platelet adenylyl cyclase signaling remains unaltered in children undergoing hemodialysis treatment

Platelet adenylyl cyclase signaling remains unaltered in children undergoing hemodialysis treatment

Vascular responses to neuropeptide Y are greater in female than male rats

Neuropeptide Y and neurovascular control in skeletal muscle and skin

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