Regulation of Neutrophil Function by Marine n-3 Fatty Acids—A Mini Review

McDaniel, Jodi C.

doi:10.1007/s12013-021-01001-z

Cited by 4 publications

(4 citation statements)

References 65 publications

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“…The EPA and DHA-derived metabolites are less inflammatory than those derived from the omega-6 precursor, arachidonic acid [1,33,[37][38][39][40][41][42]. SPMs derived from EPA and DHA reduce neutrophil infiltration and production of reactive oxygen species, regulate the cytokinechemokine axis, and temper the inflammatory response without immunosuppression [37,[43][44][45].…”

Section: Introductionmentioning

confidence: 99%

The omega-3 index is inversely associated with the neutrophil-lymphocyte ratio in adults’

McBurney

Tintle

Harris

2022

Prostaglandins, Leukotrienes and Essential Fatty Acids

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Section: Introductionmentioning

confidence: 99%

The omega-3 index is inversely associated with the neutrophil-lymphocyte ratio in adults’

McBurney

Tintle

Harris

2022

Prostaglandins, Leukotrienes and Essential Fatty Acids

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“…Functional fatty acids in diet have been shown to influence PG synthesis in a variety of ways, including the provision of substrates in PG synthesis, influencing the expression and concentration of associated enzymes, and acting as substrates and competitive inhibitors of cyclooxygenases [ 120 ]. Furthermore, the proportion of functional fatty acids, especially PUFAs, in diet alters the phospholipid composition in the cell membrane, indicating the importance of fatty acids, because different PG precursors compete for the same enzyme system [ 121 ]. Previous research has demonstrated that adding functional fatty acids to feed can regulate the gene expression of important enzymes in the PG biosynthesis pathway, such as PTGS [ 122 ], in the first trimester of pregnancy, thereby benefiting the overall porcine reproductive process [ 123 ].…”

Section: Mechanism Of Functional Fatty Acids In Increasing the Livest...mentioning

confidence: 99%

Role of functional fatty acids in modulation of reproductive potential in livestock

Zeng

Liu

et al. 2023

J Animal Sci Biotechnol

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Fatty acids are not only widely known as energy sources, but also play important roles in many metabolic pathways. The significance of fatty acids in modulating the reproductive potential of livestock has received greater recognition in recent years. Functional fatty acids and their metabolites improve follicular development, oocyte maturation and embryo development, as well as endometrial receptivity and placental vascular development, through enhancing energy supply and precursors for the synthesis of their productive hormones, such as steroid hormones and prostaglandins. However, many studies are focused on the impacts of individual functional fatty acids in the reproductive cycle, lacking studies involved in deeper mechanisms and optimal fatty acid requirements for specific physiological stages. Therefore, an overall consideration of the combination and synergy of functional fatty acids and the establishment of optimal fatty acid requirement for specific stages is needed to improve reproductive potential in livestock.

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“…The mechanism of action of PUFAs on the production of PGs includes altering the expression of various relevant enzymes and their concentrations, as well as serving as substrates and competitive inhibitors of epoxidation [ 43 ]. The ratio of different PUFAs in the diet changes the phospholipid composition of the cell membrane, which is crucial in terms of quantity, since each group of PG precursors is competing for the same enzyme system for metabolism [ 44 ]. This, in turn, can have a significant impact on the type of PG synthesis and physiological response [ 45 ].…”

Section: Pufas Pgs Cox-2 Cox-1 and Endometrial Receptivitymentioning

confidence: 99%

Insight on Polyunsaturated Fatty Acids in Endometrial Receptivity

et al. 2021

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Endometrial receptivity plays a crucial role in fertilization as well as pregnancy outcome in patients faced with fertility challenges. The optimization of endometrial receptivity may help with normal implantation of the embryo, and endometrial receptivity may be affected by numerous factors. Recently, the role of lipids in pregnancy has been increasingly recognized. Fatty acids and their metabolites may be involved in all stages of pregnancy and play a role in supporting cell proliferation and development, participating in cell signaling and regulating cell function. Polyunsaturated fatty acids, in particular, are essential fatty acids for the human body that can affect the receptivity of the endometrium through in a variety of methods, such as producing prostaglandins, estrogen and progesterone, among others. Additionally, polyunsaturated fatty acids are also involved in immunity and the regulation of endometrial decidualization. Fatty acids are essential for fetal placental growth and development. The interrelationship of polyunsaturated fatty acids with these substances and how they may affect endometrial receptivity will be reviewed in this article.

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Regulation of Neutrophil Function by Marine n-3 Fatty Acids—A Mini Review

Cited by 4 publications

References 65 publications

The omega-3 index is inversely associated with the neutrophil-lymphocyte ratio in adults’

The omega-3 index is inversely associated with the neutrophil-lymphocyte ratio in adults’

Role of functional fatty acids in modulation of reproductive potential in livestock

Insight on Polyunsaturated Fatty Acids in Endometrial Receptivity

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