Regulation of mRNA expression encoding chaperone and co-chaperone proteins of the glucocorticoid receptor in peripheral blood: association with depressive symptoms during pregnancy

Katz, E. R.; Stowe, Zachary N.; Newport, D. Jeffrey; Kelley, Mary E.; Pace, Thaddeus W.W.; Cubells, Joseph F.; Binder, Elisabeth B.

doi:10.1017/s0033291711002121

Cited by 48 publications

(40 citation statements)

References 86 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our findings are consistent with the hypotheses of hormone sensitivity-mediated PPD risk put forth by Bloch et al, as well as previous work implicating an increased sensitivity of the stress system with antenatal depression (Katz et al, 2012).…”

supporting

confidence: 93%

Seeing the Future: Epigenetic Biomarkers of Postpartum Depression

Kaminsky

Payne

2013

Neuropsychopharmacol

View full text Add to dashboard Cite

supporting

confidence: 93%

Seeing the Future: Epigenetic Biomarkers of Postpartum Depression

Kaminsky

Payne

2013

Neuropsychopharmacol

View full text Add to dashboard Cite

“…Indeed, there is evidence that normal pregnancy is associated with glucocorticoid resistance, as indicated by studies showing impaired GR-mediated negative-feedback regulation of the HPA axis [18], and reduced GR function [19]. Consistent with this, both the HPA axis and the inflammatory system are hyperactive during normal pregnancy.…”

Section: Clinical Relevance Of Antenatal Depressionmentioning

confidence: 82%

“…Consistent with this, both the HPA axis and the inflammatory system are hyperactive during normal pregnancy. More importantly, there is also specific evidence that GR resistance is more marked in women who experience depressive symptoms or stress during pregnancy, as shown by both a further reduction of GR function [19] and an even higher activity of the HPA axis and the inflammatory system [20,21]. We propose that these biological changes affect both mothers' and children's behaviour.…”

Section: Clinical Relevance Of Antenatal Depressionmentioning

confidence: 82%

Depression during pregnancy: molecular regulations of mothers’ and children's behaviour

Pariante

2014

Biochemical Society Transactions

View full text Add to dashboard Cite

Depression in pregnancy (also called 'antenatal depression') is being increasingly recognized as a clinically relevant condition that affects obstetric outcome, maternal behaviour and children's future mental health. The present review focuses on the molecular mechanisms operating in utero that underlie the potential effects of antenatal depression on mothers' and children's behaviour. In particular, I discuss evidence, coming largely from animal and cellular studies, that activation of the main hormonal stress-response system, the HPA (hypothalamic-pituitary-adrenal) axis, in mothers who are depressed during pregnancy may affect maternal care as well as offspring's behaviour and future psychopathology. The evidence summarized in the present review supports the notion that preventing or treating depression in pregnancy will alleviate not only the suffering of mothers, but also the suffering of the next generation.

show abstract

“…Recently, it was shown that the minor allele is associated with decreased abundance of the predominant GRalpha receptor isoform in the dorsolateral prefrontal cortex, which results in abnormal GR expression (Sinclair et al, 2012). Katz et al (2012) found increased expression of NR3C1 and FKBP5 during pregnancy. In depressed women, the increase in FKBP5 expression was smaller than in non-depressed women.…”

Section: Discussionmentioning

confidence: 99%

Variation in the Glucocorticoid Receptor Gene at rs41423247 Moderates the Effect of Prenatal Maternal Psychological Symptoms on Child Cortisol Reactivity and Behavior

Velders

Dieleman

Cents

et al. 2012

Neuropsychopharmacol

View full text Add to dashboard Cite

Prenatal maternal psychopathology affects child development, but some children seem more vulnerable than others. Genetic variance in hypothalamic-pituitary-adrenal axis genes may influence the effect of prenatal maternal psychological symptoms on child emotional and behavioral problems. This hypothesis was tested in the Generation R Study, a population-based cohort from fetal life onward. In total, 1727 children of Northern European descent and their mothers participated in this study and were genotyped for variants in the glucocorticoid receptor (GR) gene (rs6189/rs6190, rs10052957, rs41423247, rs6195, and rs6198) and the FK506-binding protein 5 (FKBP5) gene (rs1360780). Prenatal maternal psychological symptoms were assessed at 20 weeks pregnancy and child behavior was assessed by both parents at 3 years. In a subsample of 331 children, data about cortisol reactivity were available. Based on power calculations, only those genetic variants with sufficient minor allele frequencies (rs41423247, rs10052957, and rs1360780) were included in the interaction analyses. We found that variation in GR at rs41423247 moderates the effect of prenatal maternal psychological symptoms on child emotional and behavioral problems (beta 0.41, SE 0.16, p ¼ 0.009). This prenatal interaction effect was independent of mother's genotype and maternal postnatal psychopathology, and not found for prenatal psychological symptoms of the father. Moreover, the interaction between rs41423247 and prenatal psychological symptoms was also associated with decreased child cortisol reactivity (beta À2.30, p-value 0.05). These findings emphasize the potential effect of prenatal gene-environment interaction, and give insight in possible mechanisms accounting for children's individual vulnerability to develop emotional and behavioral problems.

show abstract

Regulation of mRNA expression encoding chaperone and co-chaperone proteins of the glucocorticoid receptor in peripheral blood: association with depressive symptoms during pregnancy

Cited by 48 publications

References 86 publications

Seeing the Future: Epigenetic Biomarkers of Postpartum Depression

Seeing the Future: Epigenetic Biomarkers of Postpartum Depression

Depression during pregnancy: molecular regulations of mothers’ and children's behaviour

Variation in the Glucocorticoid Receptor Gene at rs41423247 Moderates the Effect of Prenatal Maternal Psychological Symptoms on Child Cortisol Reactivity and Behavior

Contact Info

Product

Resources

About