2013
DOI: 10.1038/npp.2013.238
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Seeing the Future: Epigenetic Biomarkers of Postpartum Depression

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Cited by 12 publications
(6 citation statements)
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“…Epigenetic changes have also been associated with neuroinflammatory changes [227]. Specific epigenetic changes have been demonstrated in women who later develop postpartum depression at the HP1BP3 gene [228], which has also been shown to be sensitive to estradiol regulation [110] and critical to normal maternal care [111]. Therefore, there is a bidirectional relationship between epigenetic, neuroendocrine and neuroinflammatory changes which may collectively influence mood during the postpartum period (Figures 1, 3, 4, 5).…”
Section: Discussionmentioning
confidence: 99%
“…Epigenetic changes have also been associated with neuroinflammatory changes [227]. Specific epigenetic changes have been demonstrated in women who later develop postpartum depression at the HP1BP3 gene [228], which has also been shown to be sensitive to estradiol regulation [110] and critical to normal maternal care [111]. Therefore, there is a bidirectional relationship between epigenetic, neuroendocrine and neuroinflammatory changes which may collectively influence mood during the postpartum period (Figures 1, 3, 4, 5).…”
Section: Discussionmentioning
confidence: 99%
“…65 Furthermore, different etiologies may be present within MDP depending on whether symptoms onset prenatally or in the postpartum. 66 At least one group has investigated the relationship between risk for postpartum depression and perturbed prenatal DNAm patterns in proximity to genomic regions differentially methylated by estrogen. 67 For all of its strengths, this study was not without limitations.…”
Section: Discussionmentioning
confidence: 99%
“…Recent studies have implicated epigenetic processes in the pathophysiology of MDD ( 108 ). Guintivano et al ( 109 ) and Kaminsky and Payne ( 110 ) observed enhanced sensitivity to estrogen-based DNA methylation reprogramming in those at risk for PPD and identified two potential biomarker loci at the HP1BP3 and TTC9B genes that predicted PPD. Using blood drawn during pregnancy, DNA methylation at two genomic locations with an area under the receiver operator characteristic (ROC) curve [area under the curve (AUC)] of 0.87 in antenatally euthymic women and 0.12 in a replication sample of antenatally depressed women, along with complete blood count data, produced an AUC of 0.96 across both prepartum depressed and euthymic women ( 109 ).…”
Section: Biological Predictors and Biomarkers For Ppdmentioning
confidence: 99%