Regulation of microglia-mediated inflammation by host lncRNA Gm20559 upon flaviviral infection

Mohapatra, Stuti; Tripathi, Shraddha; Sharma, Vivek; Basu, Anirban

doi:10.1016/j.cyto.2023.156383

Cited by 3 publications

(1 citation statement)

References 70 publications

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“…LncRNA-SUSAJ1 , in turn hampers JEV replication and interrupts the transmission of JEV [ 115 , 116 ]. In addition, several broad-spectrum regulatory lncRNAs, such as JINR1 , ZAP-IT1 , MALAT1 , and Gm20559 , are characterized in flaviviral diseases [ 117 , 118 , 119 , 120 ]. For instance, the flavivirus-induced lncRNA JINR1 , mediated by NF-κB, is considered to be the facilitator of EV/DENV/WNV replication.…”

Section: Lncrnas In Viral Zoonosesmentioning

confidence: 99%

Unveiling the Hidden Regulators: The Impact of lncRNAs on Zoonoses

Xu,

He,

Yang

et al. 2024

IJMS

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Zoonoses are diseases and infections naturally transmitted between humans and vertebrate animals. They form the dominant group of diseases among emerging infectious diseases and represent critical threats to global health security. This dilemma is largely attributed to our insufficient knowledge of the pathogenesis regarding zoonotic spillover. Long non-coding RNAs (lncRNAs) are transcripts with limited coding capacity. Recent technological advancements have enabled the identification of numerous lncRNAs in humans, animals, and even pathogens. An increasing body of literature suggests that lncRNAs function as key regulators in zoonotic infection. They regulate immune-related epigenetic, transcriptional, and post-transcriptional events across a broad range of organisms. In this review, we discuss the recent research progress on the roles of lncRNAs in zoonoses. We address the classification and regulatory mechanisms of lncRNAs in the interaction between host and zoonotic pathogens. Additionally, we explore the surprising function of pathogen-derived lncRNAs in mediating the pathogenicity and life cycle of zoonotic bacteria, viruses, and parasites. Understanding how these lncRNAs influence the zoonotic pathogenesis will provide important therapeutic insights to the prevention and control of zoonoses.

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